OPRK1 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of OPRK1 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of OPRK1 at tissue level.

III. Associated gene sets

GO_0019233Biological processsensory perception of pain
GO_0044849Biological processestrous cycle
GO_1901381Biological processpositive regulation of potassium ion transmembrane transport
GO_0033603Biological processpositive regulation of dopamine secretion
GO_0071333Biological processcellular response to glucose stimulus
GO_0007218Biological processneuropeptide signaling pathway
GO_0007200Biological processphospholipase C-activating G protein-coupled receptor signaling pathway
GO_0043627Biological processresponse to estrogen
GO_1990708Biological processconditioned place preference
GO_0031635Biological processadenylate cyclase-inhibiting opioid receptor signaling pathway
GO_0051607Biological processdefense response to virus
GO_1903937Biological processresponse to acrylamide
GO_0032868Biological processresponse to insulin
GO_0007600Biological processsensory perception
GO_0033685Biological processnegative regulation of luteinizing hormone secretion
GO_0046877Biological processregulation of saliva secretion
GO_1904000Biological processpositive regulation of eating behavior
GO_0045471Biological processresponse to ethanol
GO_1900745Biological processpositive regulation of p38MAPK cascade
GO_0006955Biological processimmune response
GO_0042711Biological processmaternal behavior
GO_0007193Biological processadenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
GO_0007268Biological processchemical synaptic transmission
GO_0042755Biological processeating behavior
GO_0007626Biological processlocomotory behavior
GO_0035094Biological processresponse to nicotine
GO_0071222Biological processcellular response to lipopolysaccharide
GO_0048148Biological processbehavioral response to cocaine
GO_0050951Biological processsensory perception of temperature stimulus
GO_0038003Biological processG protein-coupled opioid receptor signaling pathway
GO_0005886Cellular componentplasma membrane
GO_0016020Cellular componentmembrane
GO_0005739Cellular componentmitochondrion
GO_0043204Cellular componentperikaryon
GO_0030672Cellular componentsynaptic vesicle membrane
GO_0043679Cellular componentaxon terminus
GO_0005654Cellular componentnucleoplasm
GO_0043005Cellular componentneuron projection
GO_0042734Cellular componentpresynaptic membrane
GO_0030425Cellular componentdendrite
GO_0030315Cellular componentT-tubule
GO_0005829Cellular componentcytosol
GO_0016529Cellular componentsarcoplasmic reticulum
GO_0045211Cellular componentpostsynaptic membrane
GO_0004985Molecular functionG protein-coupled opioid receptor activity
GO_0038048Molecular functiondynorphin receptor activity
GO_0042923Molecular functionneuropeptide binding
GO_0033612Molecular functionreceptor serine/threonine kinase binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameOPRK1
Protein nameOpioid receptor kappa 1
Kappa-type opioid receptor (K-OR-1) (KOR-1)
Kappa-type opioid receptor
SynonymsOPRK
KOP
KOR1
KOR
DescriptionFUNCTION: G-protein coupled opioid receptor that functions as a receptor for endogenous alpha-neoendorphins and dynorphins, but has low affinity for beta-endorphins. Also functions as a receptor for various synthetic opioids and for the psychoactive diterpene salvinorin A. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain. Plays a role in mediating reduced physical activity upon treatment with synthetic opioids. Plays a role in the regulation of salivation in response to synthetic opioids. May play a role in arousal and regulation of autonomic and neuroendocrine functions. .

FUNCTION: G-protein coupled opioid receptor that functions as a receptor for endogenous alpha-neoendorphins and dynorphins, but has low affinity for beta-endorphins. Also functions as a receptor for various synthetic opioids and for the psychoactive diterpene salvinorin A. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain. Plays a role in mediating reduced physical activity upon treatment with synthetic opioids. Plays a role in the regulation of salivation in response to synthetic opioids. May play a role in arousal and regulation of autonomic and neuroendocrine functions. .

FUNCTION: G-protein coupled opioid receptor that functions as a receptor for endogenous alpha-neoendorphins and dynorphins, but has low affinity for beta-endorphins. Also functions as a receptor for various synthetic opioids and for the psychoactive diterpene salvinorin A. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain. Plays a role in mediating reduced physical activity upon treatment with synthetic opioids. Plays a role in the regulation of salivation in response to synthetic opioids. May play a role in arousal and regulation of autonomic and neuroendocrine functions. .

AccessionsE5RJI5
P41145
A0A6H0WCN5
ENST00000520287.5 [P41145-1]
A0A6H0WB68
ENST00000524278.5 [P41145-2]
ENST00000265572.8 [P41145-1]
ENST00000673285.2
A0A5F9ZI09
ENST00000522508.1