PRKD1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0030148Biological processsphingolipid biosynthetic process
GO_0018105Biological processpeptidyl-serine phosphorylation
GO_1904628Biological processcellular response to phorbol 13-acetate 12-myristate
GO_0001525Biological processangiogenesis
GO_0060298Biological processpositive regulation of sarcomere organization
GO_0006954Biological processinflammatory response
GO_0007200Biological processphospholipase C-activating G protein-coupled receptor signaling pathway
GO_0071447Biological processcellular response to hydroperoxide
GO_0010976Biological processpositive regulation of neuron projection development
GO_0043536Biological processpositive regulation of blood vessel endothelial cell migration
GO_0045766Biological processpositive regulation of angiogenesis
GO_0045087Biological processinnate immune response
GO_2001044Biological processregulation of integrin-mediated signaling pathway
GO_0050829Biological processdefense response to Gram-negative bacterium
GO_0007165Biological processsignal transduction
GO_0010595Biological processpositive regulation of endothelial cell migration
GO_0033138Biological processpositive regulation of peptidyl-serine phosphorylation
GO_0010628Biological processpositive regulation of gene expression
GO_0018107Biological processpeptidyl-threonine phosphorylation
GO_0042307Biological processpositive regulation of protein import into nucleus
GO_0045806Biological processnegative regulation of endocytosis
GO_0046827Biological processpositive regulation of protein export from nucleus
GO_0090277Biological processpositive regulation of peptide hormone secretion
GO_0045669Biological processpositive regulation of osteoblast differentiation
GO_0048193Biological processGolgi vesicle transport
GO_0051092Biological processpositive regulation of NF-kappaB transcription factor activity
GO_0071874Biological processcellular response to norepinephrine stimulus
GO_1900227Biological processpositive regulation of NLRP3 inflammasome complex assembly
GO_0007030Biological processGolgi organization
GO_0007229Biological processintegrin-mediated signaling pathway
GO_0035556Biological processintracellular signal transduction
GO_0034599Biological processcellular response to oxidative stress
GO_1990859Biological processcellular response to endothelin
GO_0001938Biological processpositive regulation of endothelial cell proliferation
GO_0043123Biological processpositive regulation of canonical NF-kappaB signal transduction
GO_0030154Biological processcell differentiation
GO_0010508Biological processpositive regulation of autophagy
GO_2001028Biological processpositive regulation of endothelial cell chemotaxis
GO_0034198Biological processcellular response to amino acid starvation
GO_0006915Biological processapoptotic process
GO_0048010Biological processvascular endothelial growth factor receptor signaling pathway
GO_0051279Biological processregulation of release of sequestered calcium ion into cytosol
GO_0051897Biological processpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
GO_0045793Biological processpositive regulation of cell size
GO_0046777Biological processprotein autophosphorylation
GO_0010837Biological processregulation of keratinocyte proliferation
GO_0035924Biological processcellular response to vascular endothelial growth factor stimulus
GO_0007399Biological processnervous system development
GO_0014723Biological processregulation of skeletal muscle contraction by modulation of calcium ion sensitivity of myofibril
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_1904385Biological processcellular response to angiotensin
GO_0005886Cellular componentplasma membrane
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_0030018Cellular componentZ disc
GO_0000421Cellular componentautophagosome membrane
GO_0005794Cellular componentGolgi apparatus
GO_0005911Cellular componentcell-cell junction
GO_0005802Cellular componenttrans-Golgi network
GO_0005829Cellular componentcytosol
GO_0005938Cellular componentcell cortex
GO_0005634Cellular componentnucleus
GO_0005080Molecular functionprotein kinase C binding
GO_0141038Molecular functionphosphatidylinositol 3-kinase activator activity
GO_0106310Molecular functionprotein serine kinase activity
GO_0031072Molecular functionheat shock protein binding
GO_0004674Molecular functionprotein serine/threonine kinase activity
GO_0042802Molecular functionidentical protein binding
GO_0046872Molecular functionmetal ion binding
GO_0005524Molecular functionATP binding
GO_0016301Molecular functionkinase activity
GO_0004697Molecular functiondiacylglycerol-dependent serine/threonine kinase activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene namePRKD1
Protein nameSerine/threonine-protein kinase (EC 2.7.11.13)
Serine/threonine-protein kinase D1 (EC 2.7.11.13) (Protein kinase C mu type) (Protein kinase D) (nPKC-D1) (nPKC-mu)
Protein kinase D1
SynonymsPKD
PRKCM
PKD1
DescriptionFUNCTION: Serine/threonine-protein kinase that converts transient diacylglycerol (DAG) signals into prolonged physiological effects downstream of PKC, and is involved in the regulation of MAPK8/JNK1 and Ras signaling, Golgi membrane integrity and trafficking, cell survival through NF-kappa-B activation, cell migration, cell differentiation by mediating HDAC7 nuclear export, cell proliferation via MAPK1/3 (ERK1/2) signaling, and plays a role in cardiac hypertrophy, VEGFA-induced angiogenesis, genotoxic-induced apoptosis and flagellin-stimulated inflammatory response . Phosphorylates the epidermal growth factor receptor (EGFR) on dual threonine residues, which leads to the suppression of epidermal growth factor (EGF)-induced MAPK8/JNK1 activation and subsequent JUN phosphorylation . Phosphorylates RIN1, inducing RIN1 binding to 14-3-3 proteins YWHAB, YWHAE and YWHAZ and increased competition with RAF1 for binding to GTP-bound form of Ras proteins (NRAS, HRAS and KRAS). Acts downstream of the heterotrimeric G-protein beta/gamma-subunit complex to maintain the structural integrity of the Golgi membranes, and is required for protein transport along the secretory pathway. In the trans-Golgi network (TGN), regulates the fission of transport vesicles that are on their way to the plasma membrane. May act by activating the lipid kinase phosphatidylinositol 4-kinase beta (PI4KB) at the TGN for the local synthesis of phosphorylated inositol lipids, which induces a sequential production of DAG, phosphatidic acid (PA) and lyso-PA (LPA) that are necessary for membrane fission and generation of specific transport carriers to the cell surface. Under oxidative stress, is phosphorylated at Tyr-463 via SRC-ABL1 and contributes to cell survival by activating IKK complex and subsequent nuclear translocation and activation of NFKB1 . Involved in cell migration by regulating integrin alpha-5/beta-3 recycling and promoting its recruitment in newly forming focal adhesion. In osteoblast differentiation, mediates the bone morphogenetic protein 2 (BMP2)-induced nuclear export of HDAC7, which results in the inhibition of HDAC7 transcriptional repression of RUNX2 . In neurons, plays an important role in neuronal polarity by regulating the biogenesis of TGN-derived dendritic vesicles, and is involved in the maintenance of dendritic arborization and Golgi structure in hippocampal cells. May potentiate mitogenesis induced by the neuropeptide bombesin or vasopressin by mediating an increase in the duration of MAPK1/3 (ERK1/2) signaling, which leads to accumulation of immediate-early gene products including FOS that stimulate cell cycle progression. Plays an important role in the proliferative response induced by low calcium in keratinocytes, through sustained activation of MAPK1/3 (ERK1/2) pathway. Downstream of novel PKC signaling, plays a role in cardiac hypertrophy by phosphorylating HDAC5, which in turn triggers XPO1/CRM1-dependent nuclear export of HDAC5, MEF2A transcriptional activation and induction of downstream target genes that promote myocyte hypertrophy and pathological cardiac remodeling . Mediates cardiac troponin I (TNNI3) phosphorylation at the PKA sites, which results in reduced myofilament calcium sensitivity, and accelerated crossbridge cycling kinetics. The PRKD1-HDAC5 pathway is also involved in angiogenesis by mediating VEGFA-induced specific subset of gene expression, cell migration, and tube formation . In response to VEGFA, is necessary and required for HDAC7 phosphorylation which induces HDAC7 nuclear export and endothelial cell proliferation and migration. During apoptosis induced by cytarabine and other genotoxic agents, PRKD1 is cleaved by caspase-3 at Asp-378, resulting in activation of its kinase function and increased sensitivity of cells to the cytotoxic effects of genotoxic agents . In epithelial cells, is required for transducing flagellin-stimulated inflammatory responses by binding and phosphorylating TLR5, which contributes to MAPK14/p38 activation and production of inflammatory cytokines . Acts as an activator of NLRP3 inflammasome assembly by mediating phosphorylation of NLRP3 (By similarity). May play a role in inflammatory response by mediating activation of NF-kappa-B. May be involved in pain transmission by directly modulating TRPV1 receptor . Plays a role in activated KRAS-mediated stabilization of ZNF304 in colorectal cancer (CRC) cells . Regulates nuclear translocation of transcription factor TFEB in macrophages upon live S.enterica infection (By similarity). .

AccessionsQ1KKQ2
H0YHL5
ENST00000549503.1
A0A494C0Q1
Q15139
ENST00000651571.1
ENST00000490795.1
ENST00000331968.11
F8WBA3
A0A494C196
F8VZ98
ENST00000415220.6
ENST00000546371.1
ENST00000651616.1
H0YHS9