I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| neuroendocrine cell | 4 studies | 69% ± 29% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| neuroendocrine cell | 4 studies | 69% ± 29% |
Insufficient scRNA-seq data for expression of CALCA at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| prostate | 87% | 116.08 | 212 / 245 | 60% | 2.96 | 301 / 502 |
| kidney | 97% | 322.66 | 86 / 89 | 9% | 5.95 | 85 / 901 |
| liver | 81% | 1129.99 | 182 / 226 | 25% | 6.73 | 101 / 406 |
| lung | 78% | 68.34 | 448 / 578 | 19% | 154.89 | 216 / 1155 |
| thymus | 70% | 5838.42 | 458 / 653 | 20% | 11.55 | 118 / 605 |
| spleen | 86% | 144.22 | 208 / 241 | 0% | 0 | 0 / 0 |
| intestine | 53% | 15.49 | 513 / 966 | 26% | 2.50 | 139 / 527 |
| adrenal gland | 30% | 8.35 | 78 / 258 | 31% | 27.85 | 72 / 230 |
| bladder | 43% | 25.48 | 9 / 21 | 13% | 13.92 | 66 / 504 |
| pancreas | 47% | 13.13 | 153 / 328 | 9% | 0.21 | 16 / 178 |
| blood vessel | 52% | 41.91 | 690 / 1335 | 0% | 0 | 0 / 0 |
| stomach | 31% | 8.47 | 113 / 359 | 19% | 16.91 | 53 / 286 |
| heart | 43% | 36.24 | 371 / 861 | 0% | 0 | 0 / 0 |
| adipose | 33% | 21.91 | 402 / 1204 | 0% | 0 | 0 / 0 |
| ovary | 25% | 5.54 | 45 / 180 | 4% | 0.17 | 18 / 430 |
| brain | 27% | 11.65 | 724 / 2642 | 1% | 0.06 | 8 / 705 |
| breast | 23% | 12.17 | 107 / 459 | 3% | 0.45 | 39 / 1118 |
| uterus | 14% | 4.68 | 24 / 170 | 12% | 6.30 | 54 / 459 |
| esophagus | 15% | 4.97 | 216 / 1445 | 8% | 3.43 | 15 / 183 |
| muscle | 16% | 12.83 | 132 / 803 | 0% | 0 | 0 / 0 |
| skin | 7% | 1.58 | 129 / 1809 | 1% | 0.13 | 4 / 472 |
| tonsil | 0% | 0 | 0 / 0 | 7% | 0.22 | 3 / 45 |
| peripheral blood | 4% | 1.64 | 35 / 929 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 1% | 0.01 | 1 / 80 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 29 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0030279 | Biological process | negative regulation of ossification |
| GO_0006939 | Biological process | smooth muscle contraction |
| GO_0051480 | Biological process | regulation of cytosolic calcium ion concentration |
| GO_0031623 | Biological process | receptor internalization |
| GO_0009408 | Biological process | response to heat |
| GO_0007218 | Biological process | neuropeptide signaling pathway |
| GO_0045986 | Biological process | negative regulation of smooth muscle contraction |
| GO_0006954 | Biological process | inflammatory response |
| GO_0007200 | Biological process | phospholipase C-activating G protein-coupled receptor signaling pathway |
| GO_0045651 | Biological process | positive regulation of macrophage differentiation |
| GO_0045779 | Biological process | negative regulation of bone resorption |
| GO_0007631 | Biological process | feeding behavior |
| GO_0008217 | Biological process | regulation of blood pressure |
| GO_1990408 | Biological process | calcitonin gene-related peptide receptor signaling pathway |
| GO_0007267 | Biological process | cell-cell signaling |
| GO_0010523 | Biological process | negative regulation of calcium ion transport into cytosol |
| GO_0032147 | Biological process | activation of protein kinase activity |
| GO_0071356 | Biological process | cellular response to tumor necrosis factor |
| GO_0001944 | Biological process | vasculature development |
| GO_0007190 | Biological process | activation of adenylate cyclase activity |
| GO_0048265 | Biological process | response to pain |
| GO_0007204 | Biological process | positive regulation of cytosolic calcium ion concentration |
| GO_0043542 | Biological process | endothelial cell migration |
| GO_0050965 | Biological process | detection of temperature stimulus involved in sensory perception of pain |
| GO_1990090 | Biological process | cellular response to nerve growth factor stimulus |
| GO_0001935 | Biological process | endothelial cell proliferation |
| GO_0001984 | Biological process | artery vasodilation involved in baroreceptor response to increased systemic arterial blood pressure |
| GO_0032757 | Biological process | positive regulation of interleukin-8 production |
| GO_0007189 | Biological process | adenylate cyclase-activating G protein-coupled receptor signaling pathway |
| GO_0002031 | Biological process | G protein-coupled receptor internalization |
| GO_0001503 | Biological process | ossification |
| GO_0006468 | Biological process | protein phosphorylation |
| GO_0002548 | Biological process | monocyte chemotaxis |
| GO_0032730 | Biological process | positive regulation of interleukin-1 alpha production |
| GO_0042311 | Biological process | vasodilation |
| GO_0045892 | Biological process | negative regulation of DNA-templated transcription |
| GO_0007566 | Biological process | embryo implantation |
| GO_0007159 | Biological process | leukocyte cell-cell adhesion |
| GO_0045671 | Biological process | negative regulation of osteoclast differentiation |
| GO_0098992 | Cellular component | neuronal dense core vesicle |
| GO_0005615 | Cellular component | extracellular space |
| GO_0005576 | Cellular component | extracellular region |
| GO_0043195 | Cellular component | terminal bouton |
| GO_0043025 | Cellular component | neuronal cell body |
| GO_0098686 | Cellular component | hippocampal mossy fiber to CA3 synapse |
| GO_0005737 | Cellular component | cytoplasm |
| GO_0044877 | Molecular function | protein-containing complex binding |
| GO_0005179 | Molecular function | hormone activity |
| GO_0005102 | Molecular function | signaling receptor binding |
| GO_0042802 | Molecular function | identical protein binding |
| GO_0031716 | Molecular function | calcitonin receptor binding |
| GO_0005515 | Molecular function | protein binding |
| Gene name | CALCA |
| Protein name | Calcitonin gene-related peptide 1 (Alpha-type CGRP) (Calcitonin gene-related peptide I) (CGRP-I) Calcitonin [Cleaved into: Calcitonin; Katacalcin (Calcitonin carboxyl-terminal peptide) (CCP) (PDN-21)] |
| Synonyms | CALC1 |
| Description | FUNCTION: Calcitonin causes a rapid but short-lived drop in the level of calcium and phosphate in blood by promoting the incorporation of those ions in the bones.; FUNCTION: Katacalcin is a potent plasma calcium-lowering peptide. FUNCTION: CGRP induces vasodilation. It dilates a variety of vessels including the coronary, cerebral and systemic vasculature. Its abundance in the CNS also points toward a neurotransmitter or neuromodulator role. It also elevates platelet cAMP. . |
| Accessions | ENST00000469608.5 [P01258-2] P06881 ENST00000706043.1 [P06881-1] ENST00000706042.1 [P06881-1] ENST00000331587.9 [P01258-1] P01258 ENST00000486207.6 [P06881-1] ENST00000396372.2 [P01258-1] |
