GPR55 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of GPR55 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of GPR55 at tissue level.

III. Associated gene sets

GO_0007186Biological processG protein-coupled receptor signaling pathway
GO_0035025Biological processpositive regulation of Rho protein signal transduction
GO_0007200Biological processphospholipase C-activating G protein-coupled receptor signaling pathway
GO_0070374Biological processpositive regulation of ERK1 and ERK2 cascade
GO_0038171Biological processcannabinoid signaling pathway
GO_0045453Biological processbone resorption
GO_0045671Biological processnegative regulation of osteoclast differentiation
GO_0005886Cellular componentplasma membrane
GO_0004930Molecular functionG protein-coupled receptor activity
GO_0004949Molecular functioncannabinoid receptor activity

IV. Literature review

[source]
Gene nameGPR55
Protein nameG protein-coupled receptor 55 (cDNA FLJ75410, highly similar to Homo sapiens G protein-coupled receptor 55, mRNA)
G protein-coupled receptor 55
G-protein coupled receptor 55
SynonymshCG_1645175
DescriptionFUNCTION: G-protein coupled receptor that binds to several ligands including 2-arachidonoyl lysophosphatidylinositol or lysophosphatidylglucoside with high affinity, leading to rapid and transient activation of numerous intracellular signaling pathways . Induces the Ca(2+) release from intracellular stores via ERK, the heterotrimeric G protein GNA13 and RHOA leading to morphological changes including cell rounding and stress fiber formation . In macrophages, acts downstream of lysophosphatidylglucoside to inhibit the translocation of the phospholipid-transporting ABCA1 to plasma membrane and subsequent cholesterol efflux leading to lipid accumulation and foam cell formation . .

AccessionsENST00000650999.1
ENST00000392039.2
ENST00000444078.5
Q9Y2T6
ENST00000392040.5
ENST00000622008.4
ENST00000438398.1
C9J1P7
A8K858