ORAI1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0045762Biological processpositive regulation of adenylate cyclase activity
GO_0007200Biological processphospholipase C-activating G protein-coupled receptor signaling pathway
GO_0051924Biological processregulation of calcium ion transport
GO_0002115Biological processstore-operated calcium entry
GO_1990806Biological processligand-gated ion channel signaling pathway
GO_0032024Biological processpositive regulation of insulin secretion
GO_0002250Biological processadaptive immune response
GO_0070509Biological processcalcium ion import
GO_0061180Biological processmammary gland epithelium development
GO_0051928Biological processpositive regulation of calcium ion transport
GO_0070588Biological processcalcium ion transmembrane transport
GO_0099105Biological procession channel modulating, G protein-coupled receptor signaling pathway
GO_0005886Cellular componentplasma membrane
GO_0045121Cellular componentmembrane raft
GO_0016020Cellular componentmembrane
GO_0044853Cellular componentplasma membrane raft
GO_0034704Cellular componentcalcium channel complex
GO_0016323Cellular componentbasolateral plasma membrane
GO_0042802Molecular functionidentical protein binding
GO_0015279Molecular functionstore-operated calcium channel activity
GO_0005516Molecular functioncalmodulin binding
GO_0005515Molecular functionprotein binding
GO_0005262Molecular functioncalcium channel activity

IV. Literature review

[source]
Gene nameORAI1
Protein nameCalcium release-activated calcium channel protein 1 (Protein orai-1) (Transmembrane protein 142A)
SynonymsTMEM142A
CRACM1
DescriptionFUNCTION: Ca(2+) release-activated Ca(2+) (CRAC) channel subunit which mediates Ca(2+) influx following depletion of intracellular Ca(2+) stores and channel activation by the Ca(2+) sensor, STIM1 . CRAC channels are the main pathway for Ca(2+) influx in T-cells and promote the immune response to pathogens by activating the transcription factor NFAT . Plays a prominent role in Ca(2+) influx at the basolateral membrane of mammary epithelial cells independently of the Ca(2+) content of endoplasmic reticulum or Golgi stores. May mediate transepithelial transport of large quantities of Ca(2+) for milk secretion. .

AccessionsENST00000617316.2 [Q96D31-1]
Q96D31