PTGER3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0060455Biological processnegative regulation of gastric acid secretion
GO_0014827Biological processintestine smooth muscle contraction
GO_0007186Biological processG protein-coupled receptor signaling pathway
GO_0007204Biological processpositive regulation of cytosolic calcium ion concentration
GO_0006954Biological processinflammatory response
GO_0007200Biological processphospholipase C-activating G protein-coupled receptor signaling pathway
GO_0031622Biological processpositive regulation of fever generation
GO_0008219Biological processcell death
GO_0007189Biological processadenylate cyclase-activating G protein-coupled receptor signaling pathway
GO_0005886Cellular componentplasma membrane
GO_0005635Cellular componentnuclear envelope
GO_0016020Cellular componentmembrane
GO_0004957Molecular functionprostaglandin E receptor activity

IV. Literature review

[source]
Gene namePTGER3
Protein nameProstaglandin E2 receptor EP3 subtype (Prostanoid EP3 receptor)
Prostaglandin E2 receptor EP3 subtype (PGE receptor EP3 subtype) (PGE2 receptor EP3 subtype) (PGE2-R) (Prostanoid EP3 receptor)
SynonymsEP3-I
hCG_1811960
EP3f
DescriptionFUNCTION: Receptor for prostaglandin E2 (PGE2) . The activity of this receptor can couple to both the inhibition of adenylate cyclase mediated by G(i) proteins, and to an elevation of intracellular calcium . Required for normal development of fever in response to pyrinogens, including IL1B, prostaglandin E2 and bacterial lipopolysaccharide (LPS). Required for normal potentiation of platelet aggregation by prostaglandin E2, and thus plays a role in the regulation of blood coagulation. Required for increased HCO3(-) secretion in the duodenum in response to mucosal acidification, and thereby contributes to the protection of the mucosa against acid-induced ulceration. Not required for normal kidney function, normal urine volume and osmolality (By similarity). .

AccessionsENST00000370931.7 [P43115-1]
ENST00000497146.5
ENST00000628037.2 [P43115-3]
P43115
B2KKV4
ENST00000460330.5 [P43115-4]
ENST00000356595.8 [P43115-5]
Q147U0
A0A0B4J204
O00325
Q5CZ60
ENST00000479353.5 [P43115-7]
ENST00000306666.10 [P43115-1]
ENST00000370924.5 [P43115-2]
Q6TTN3
ENST00000361210.6
Q5CZ57