GPR18 | OmnibusX

sc-RNAseq data

Insufficient scRNA-seq data for expression of GPR18 at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
lung	95%	42.45	550 / 578	55%	1.95	633 / 1155
esophagus	69%	18.79	998 / 1445	55%	1.17	100 / 183
intestine	85%	79.66	819 / 966	35%	1.28	184 / 527
stomach	67%	15.01	240 / 359	52%	2.10	149 / 286
breast	63%	13.50	287 / 459	52%	1.96	578 / 1118
kidney	66%	19.15	59 / 89	44%	1.23	398 / 901
prostate	94%	33.58	231 / 245	16%	0.48	81 / 502
thymus	79%	32.14	516 / 653	30%	1.40	183 / 605
skin	53%	12.29	958 / 1809	52%	2.62	244 / 472
bladder	76%	19.67	16 / 21	28%	1.51	140 / 504
lymph node	0%	0	0 / 0	100%	34.02	29 / 29
spleen	100%	607.68	241 / 241	0%	0	0 / 0
peripheral blood	100%	256.07	925 / 929	0%	0	0 / 0
uterus	62%	12.00	106 / 170	34%	0.99	154 / 459
liver	81%	22.55	184 / 226	13%	0.44	51 / 406
ovary	51%	10.67	92 / 180	24%	0.43	104 / 430
adipose	71%	19.52	851 / 1204	0%	0	0 / 0
pancreas	26%	4.08	84 / 328	42%	1.95	75 / 178
tonsil	0%	0	0 / 0	67%	3.33	30 / 45
adrenal gland	47%	7.41	120 / 258	3%	0.03	6 / 230
heart	43%	8.01	368 / 861	0%	0	0 / 0
blood vessel	37%	9.07	499 / 1335	0%	0	0 / 0
brain	16%	2.19	420 / 2642	4%	0.10	27 / 705
muscle	11%	1.76	86 / 803	0%	0	0 / 0
eye	0%	0	0 / 0	10%	0.30	8 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

GO_0007186	Biological process	G protein-coupled receptor signaling pathway
GO_0002689	Biological process	negative regulation of leukocyte chemotaxis
GO_0032720	Biological process	negative regulation of tumor necrosis factor production
GO_0007200	Biological process	phospholipase C-activating G protein-coupled receptor signaling pathway
GO_0035025	Biological process	positive regulation of Rho protein signal transduction
GO_0002305	Biological process	CD8-positive, gamma-delta intraepithelial T cell differentiation
GO_0002300	Biological process	CD8-positive, alpha-beta intraepithelial T cell differentiation
GO_0016020	Cellular component	membrane
GO_0005886	Cellular component	plasma membrane
GO_0030659	Cellular component	cytoplasmic vesicle membrane
GO_0004930	Molecular function	G protein-coupled receptor activity

Gene name	GPR18
Protein name	N-arachidonyl glycine receptor (G-protein coupled receptor 18) N-arachidonyl glycine receptor (NAGly receptor) (G-protein coupled receptor 18)
Synonyms	GPCRW
Description	FUNCTION: Receptor for endocannabinoid N-arachidonyl glycine (NAGly) . However, conflicting results about the role of NAGly as an agonist are reported . Can also be activated by plant-derived and synthetic cannabinoid agonists . The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase . May contribute to regulation of the immune system. Is required for normal homeostasis of CD8+ subsets of intraepithelial lymphocytes (IELs) (CD8alphaalpha and CD8alphabeta IELs)in small intstine by supporting preferential migration of CD8alphaalpha T-cells to intraepithelial compartment over lamina propria compartment, and by mediating their reconstitution into small intestine after bone marrow transplant (By similarity). Plays a role in hypotensive responses, mediating reduction in intraocular and blood pressure (By similarity). Mediates NAGly-induced process of reorganization of actin filaments and induction of acrosomal exocytosis . .
Accessions	ENST00000397470.5 ENST00000397473.7 Q14330 ENST00000340807.3 ENST00000416594 Q5JUH9 ENST00000416594.2

GPR18 report