F2R | OmnibusX

Name	Number of supported studies	Average coverage
fibroblast	18 studies	26% ± 8%	Explore
endothelial cell	17 studies	26% ± 9%	Explore
natural killer cell	15 studies	22% ± 6%	Explore
pericyte	14 studies	34% ± 13%	Explore
myofibroblast cell	10 studies	35% ± 10%	Explore
CD16-positive, CD56-dim natural killer cell, human	8 studies	23% ± 5%	Explore
mature NK T cell	7 studies	20% ± 4%	Explore
platelet	7 studies	20% ± 3%	Explore
CD8-positive, alpha-beta T cell	7 studies	22% ± 5%	Explore
CD8-positive, alpha-beta memory T cell	7 studies	20% ± 3%	Explore
endothelial cell of artery	6 studies	27% ± 9%	Explore
connective tissue cell	5 studies	31% ± 6%	Explore
effector CD8-positive, alpha-beta T cell	4 studies	18% ± 1%	Explore
vein endothelial cell	4 studies	24% ± 6%	Explore
effector memory CD8-positive, alpha-beta T cell	4 studies	21% ± 4%	Explore
gamma-delta T cell	4 studies	19% ± 3%	Explore
exhausted T cell	3 studies	25% ± 5%	Explore
capillary endothelial cell	3 studies	23% ± 4%	Explore
smooth muscle cell	3 studies	19% ± 4%	Explore
endothelial cell of sinusoid	3 studies	44% ± 24%	Explore
megakaryocyte	3 studies	63% ± 17%	Explore
megakaryocyte-erythroid progenitor cell	3 studies	30% ± 4%	Explore

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of F2R at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
lung	100%	4192.43	577 / 578	95%	43.57	1094 / 1155
breast	93%	1795.14	429 / 459	96%	72.27	1074 / 1118
skin	99%	4500.57	1792 / 1809	88%	143.35	417 / 472
thymus	98%	1860.66	642 / 653	88%	43.31	535 / 605
intestine	89%	1246.74	855 / 966	91%	42.16	479 / 527
kidney	100%	2462.87	89 / 89	75%	70.70	673 / 901
adrenal gland	97%	2114.40	250 / 258	72%	25.30	166 / 230
esophagus	76%	887.87	1099 / 1445	90%	53.35	165 / 183
prostate	83%	1074.40	204 / 245	78%	29.55	393 / 502
uterus	88%	1177.10	149 / 170	66%	23.97	303 / 459
stomach	59%	540.40	213 / 359	93%	55.38	266 / 286
bladder	67%	852.29	14 / 21	72%	25.92	365 / 504
pancreas	24%	217.62	79 / 328	97%	85.80	172 / 178
ovary	36%	350.40	64 / 180	68%	20.89	293 / 430
liver	52%	522.86	118 / 226	49%	15.38	197 / 406
spleen	100%	4977.49	241 / 241	0%	0	0 / 0
blood vessel	100%	5951.13	1332 / 1335	0%	0	0 / 0
brain	2%	15.55	52 / 2642	96%	69.44	676 / 705
adipose	95%	2198.05	1149 / 1204	0%	0	0 / 0
heart	93%	1902.16	805 / 861	0%	0	0 / 0
tonsil	0%	0	0 / 0	76%	29.17	34 / 45
lymph node	0%	0	0 / 0	62%	22.41	18 / 29
peripheral blood	39%	505.28	366 / 929	0%	0	0 / 0
muscle	22%	180.39	176 / 803	0%	0	0 / 0
eye	0%	0	0 / 0	3%	0.39	2 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0007529	Biological process	establishment of synaptic specificity at neuromuscular junction
GO_0006919	Biological process	activation of cysteine-type endopeptidase activity involved in apoptotic process
GO_0008285	Biological process	negative regulation of cell population proliferation
GO_0006954	Biological process	inflammatory response
GO_0007200	Biological process	phospholipase C-activating G protein-coupled receptor signaling pathway
GO_0043547	Biological process	positive regulation of GTPase activity
GO_0002248	Biological process	connective tissue replacement involved in inflammatory response wound healing
GO_1900134	Biological process	negative regulation of renin secretion into blood stream
GO_0045907	Biological process	positive regulation of vasoconstriction
GO_0051930	Biological process	regulation of sensory perception of pain
GO_0099553	Biological process	trans-synaptic signaling by endocannabinoid, modulating synaptic transmission
GO_0070493	Biological process	thrombin-activated receptor signaling pathway
GO_0032496	Biological process	response to lipopolysaccharide
GO_0043410	Biological process	positive regulation of MAPK cascade
GO_0051209	Biological process	release of sequestered calcium ion into cytosol
GO_0036145	Biological process	dendritic cell homeostasis
GO_0043280	Biological process	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO_0048873	Biological process	homeostasis of number of cells within a tissue
GO_0030168	Biological process	platelet activation
GO_0030193	Biological process	regulation of blood coagulation
GO_0048167	Biological process	regulation of synaptic plasticity
GO_0007186	Biological process	G protein-coupled receptor signaling pathway
GO_0045987	Biological process	positive regulation of smooth muscle contraction
GO_0007204	Biological process	positive regulation of cytosolic calcium ion concentration
GO_0045893	Biological process	positive regulation of DNA-templated transcription
GO_0030335	Biological process	positive regulation of cell migration
GO_0032967	Biological process	positive regulation of collagen biosynthetic process
GO_0032651	Biological process	regulation of interleukin-1 beta production
GO_0043123	Biological process	positive regulation of canonical NF-kappaB signal transduction
GO_0060155	Biological process	platelet dense granule organization
GO_0032757	Biological process	positive regulation of interleukin-8 production
GO_0030194	Biological process	positive regulation of blood coagulation
GO_0009653	Biological process	anatomical structure morphogenesis
GO_0051928	Biological process	positive regulation of calcium ion transport
GO_0051281	Biological process	positive regulation of release of sequestered calcium ion into cytosol
GO_0003105	Biological process	negative regulation of glomerular filtration
GO_0008284	Biological process	positive regulation of cell population proliferation
GO_0051897	Biological process	positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
GO_0035025	Biological process	positive regulation of Rho protein signal transduction
GO_0043524	Biological process	negative regulation of neuron apoptotic process
GO_0070374	Biological process	positive regulation of ERK1 and ERK2 cascade
GO_0009611	Biological process	response to wounding
GO_0046427	Biological process	positive regulation of receptor signaling pathway via JAK-STAT
GO_0045217	Biological process	cell-cell junction maintenance
GO_0032755	Biological process	positive regulation of interleukin-6 production
GO_0007205	Biological process	protein kinase C-activating G protein-coupled receptor signaling pathway
GO_0005576	Cellular component	extracellular region
GO_0005886	Cellular component	plasma membrane
GO_0031594	Cellular component	neuromuscular junction
GO_0005769	Cellular component	early endosome
GO_0031094	Cellular component	platelet dense tubular network
GO_0005794	Cellular component	Golgi apparatus
GO_0009986	Cellular component	cell surface
GO_0005770	Cellular component	late endosome
GO_0045211	Cellular component	postsynaptic membrane
GO_0005901	Cellular component	caveola
GO_0004930	Molecular function	G protein-coupled receptor activity
GO_0031681	Molecular function	G-protein beta-subunit binding
GO_0001965	Molecular function	G-protein alpha-subunit binding
GO_0005102	Molecular function	signaling receptor binding
GO_0015057	Molecular function	thrombin-activated receptor activity
GO_0005515	Molecular function	protein binding

Gene name	F2R
Protein name	Proteinase-activated receptor 1 (PAR-1) (Coagulation factor II receptor) (Thrombin receptor) Coagulation factor II (Thrombin) receptor, isoform CRA_b (Coagulation factor II thrombin receptor)
Synonyms	PAR1 CF2R TR hCG_37484
Description	FUNCTION: High affinity receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis. May play a role in platelets activation and in vascular development. .
Accessions	ENST00000319211.5 P25116 G3XAL6 ENST00000505600.1

F2R report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review