FFAR1 | OmnibusX

sc-RNAseq data

Insufficient scRNA-seq data for expression of FFAR1 at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
pancreas	100%	171.50	327 / 328	59%	6.60	105 / 178
ovary	98%	286.54	177 / 180	11%	0.35	49 / 430
spleen	92%	38.83	222 / 241	0%	0	0 / 0
brain	85%	67.19	2236 / 2642	7%	0.13	47 / 705
lymph node	0%	0	0 / 0	59%	2.47	17 / 29
lung	44%	11.85	255 / 578	1%	0.01	7 / 1155
intestine	38%	12.46	366 / 966	3%	0.26	14 / 527
thymus	31%	8.34	203 / 653	9%	0.30	53 / 605
adrenal gland	30%	7.91	78 / 258	6%	0.19	13 / 230
peripheral blood	33%	47.87	311 / 929	0%	0	0 / 0
uterus	25%	9.46	42 / 170	2%	0.06	8 / 459
prostate	23%	5.32	57 / 245	0%	0	0 / 502
stomach	22%	4.41	80 / 359	1%	0.02	2 / 286
bladder	19%	2.19	4 / 21	0%	0.01	2 / 504
breast	17%	3.53	77 / 459	1%	0.01	10 / 1118
esophagus	11%	1.65	163 / 1445	1%	0.01	1 / 183
adipose	12%	1.63	141 / 1204	0%	0	0 / 0
skin	3%	0.44	54 / 1809	5%	0.20	25 / 472
kidney	7%	1.17	6 / 89	1%	0.01	7 / 901
liver	3%	0.36	7 / 226	0%	0.01	1 / 406
blood vessel	3%	0.54	39 / 1335	0%	0	0 / 0
heart	2%	0.23	16 / 861	0%	0	0 / 0
muscle	0%	0.05	4 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
eye	0%	0	0 / 0	0%	0	0 / 80
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
tonsil	0%	0	0 / 0	0%	0	0 / 45
ureter	0%	0	0 / 0	0%	0	0 / 1

GO_0030073	Biological process	insulin secretion
GO_0032024	Biological process	positive regulation of insulin secretion
GO_1990806	Biological process	ligand-gated ion channel signaling pathway
GO_0007186	Biological process	G protein-coupled receptor signaling pathway
GO_0007204	Biological process	positive regulation of cytosolic calcium ion concentration
GO_0007200	Biological process	phospholipase C-activating G protein-coupled receptor signaling pathway
GO_0070542	Biological process	response to fatty acid
GO_0032691	Biological process	negative regulation of interleukin-1 beta production
GO_0042593	Biological process	glucose homeostasis
GO_0099105	Biological process	ion channel modulating, G protein-coupled receptor signaling pathway
GO_0051928	Biological process	positive regulation of calcium ion transport
GO_0005886	Cellular component	plasma membrane
GO_0045125	Molecular function	bioactive lipid receptor activity
GO_0004930	Molecular function	G protein-coupled receptor activity
GO_0008289	Molecular function	lipid binding

Gene name	FFAR1
Protein name	Free fatty acid receptor 1 (G-protein coupled receptor 40)
Synonyms	GPCR40 GPR40
Description	FUNCTION: G-protein coupled receptor for medium and long chain saturated and unsaturated fatty acids that plays an important role in glucose homeostasis. Fatty acid binding increases glucose-stimulated insulin secretion, and may also enhance the secretion of glucagon-like peptide 1 (GLP-1). May also play a role in bone homeostasis; receptor signaling activates pathways that inhibit osteoclast differentiation (By similarity). Ligand binding leads to a conformation change that triggers signaling via G-proteins that activate phospholipase C, leading to an increase of the intracellular calcium concentration. Seems to act through a G(q) and G(i)-mediated pathway. Mediates the anti-inflammatory effects of omega-3 polyunsaturated fatty acids (PUFAs) via inhibition of NLRP3 inflammasome activation. .
Accessions	Q0IJ71 ENST00000246553.4 O14842 A5Z1T7

FFAR1 report