Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| astrocyte | 12 studies | 36% ± 15% | |
| adipocyte | 8 studies | 44% ± 12% | |
| oligodendrocyte precursor cell | 8 studies | 39% ± 14% | |
| GABAergic neuron | 5 studies | 49% ± 8% | |
| hepatocyte | 4 studies | 69% ± 23% | |
| cardiac muscle cell | 4 studies | 40% ± 10% | |
| interneuron | 3 studies | 68% ± 19% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| brain | 4 studies | 22% ± 5% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| brain | 87% | 154.87 | 2304 / 2642 | 71% | 3.11 | 502 / 705 |
| prostate | 92% | 505.08 | 226 / 245 | 57% | 1.86 | 287 / 502 |
| liver | 100% | 2862.19 | 226 / 226 | 46% | 2.20 | 187 / 406 |
| lung | 99% | 561.25 | 571 / 578 | 3% | 0.08 | 37 / 1155 |
| spleen | 100% | 582.00 | 241 / 241 | 0% | 0 | 0 / 0 |
| breast | 95% | 465.58 | 436 / 459 | 2% | 0.06 | 23 / 1118 |
| adipose | 96% | 465.97 | 1156 / 1204 | 0% | 0 | 0 / 0 |
| intestine | 85% | 157.73 | 818 / 966 | 1% | 0.02 | 5 / 527 |
| stomach | 69% | 98.82 | 246 / 359 | 1% | 0.02 | 4 / 286 |
| uterus | 58% | 141.61 | 99 / 170 | 4% | 0.32 | 20 / 459 |
| blood vessel | 58% | 124.91 | 770 / 1335 | 0% | 0 | 0 / 0 |
| heart | 54% | 331.60 | 467 / 861 | 0% | 0 | 0 / 0 |
| ovary | 49% | 73.69 | 89 / 180 | 1% | 0.01 | 3 / 430 |
| bladder | 48% | 41.67 | 10 / 21 | 1% | 0.02 | 4 / 504 |
| esophagus | 47% | 82.75 | 674 / 1445 | 1% | 0.02 | 2 / 183 |
| skin | 45% | 52.89 | 814 / 1809 | 1% | 0.02 | 6 / 472 |
| kidney | 13% | 14.01 | 12 / 89 | 12% | 0.25 | 112 / 901 |
| thymus | 13% | 10.49 | 85 / 653 | 0% | 0.01 | 3 / 605 |
| adrenal gland | 7% | 4.97 | 17 / 258 | 1% | 0.11 | 2 / 230 |
| muscle | 5% | 3.38 | 38 / 803 | 0% | 0 | 0 / 0 |
| pancreas | 1% | 0.91 | 4 / 328 | 1% | 0.12 | 2 / 178 |
| peripheral blood | 1% | 1.13 | 6 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 80 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 29 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 45 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0006939 | Biological process | smooth muscle contraction |
| GO_0008285 | Biological process | negative regulation of cell population proliferation |
| GO_0071880 | Biological process | adenylate cyclase-activating adrenergic receptor signaling pathway |
| GO_0007200 | Biological process | phospholipase C-activating G protein-coupled receptor signaling pathway |
| GO_0000165 | Biological process | MAPK cascade |
| GO_0061049 | Biological process | cell growth involved in cardiac muscle cell development |
| GO_0010613 | Biological process | positive regulation of cardiac muscle hypertrophy |
| GO_0007165 | Biological process | signal transduction |
| GO_0045907 | Biological process | positive regulation of vasoconstriction |
| GO_0097195 | Biological process | pilomotor reflex |
| GO_0043410 | Biological process | positive regulation of MAPK cascade |
| GO_0007267 | Biological process | cell-cell signaling |
| GO_0001997 | Biological process | positive regulation of the force of heart contraction by epinephrine-norepinephrine |
| GO_0009725 | Biological process | response to hormone |
| GO_0045760 | Biological process | positive regulation of action potential |
| GO_0045987 | Biological process | positive regulation of smooth muscle contraction |
| GO_0007186 | Biological process | G protein-coupled receptor signaling pathway |
| GO_0035556 | Biological process | intracellular signal transduction |
| GO_0007204 | Biological process | positive regulation of cytosolic calcium ion concentration |
| GO_0007512 | Biological process | adult heart development |
| GO_0001985 | Biological process | negative regulation of heart rate involved in baroreceptor response to increased systemic arterial blood pressure |
| GO_0090037 | Biological process | positive regulation of protein kinase C signaling |
| GO_0010507 | Biological process | negative regulation of autophagy |
| GO_0006915 | Biological process | apoptotic process |
| GO_0060402 | Biological process | calcium ion transport into cytosol |
| GO_0009410 | Biological process | response to xenobiotic stimulus |
| GO_0001996 | Biological process | positive regulation of heart rate by epinephrine-norepinephrine |
| GO_0032230 | Biological process | positive regulation of synaptic transmission, GABAergic |
| GO_0070374 | Biological process | positive regulation of ERK1 and ERK2 cascade |
| GO_0150099 | Biological process | neuron-glial cell signaling |
| GO_0060452 | Biological process | positive regulation of cardiac muscle contraction |
| GO_0001994 | Biological process | norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0005654 | Cellular component | nucleoplasm |
| GO_0005829 | Cellular component | cytosol |
| GO_0005737 | Cellular component | cytoplasm |
| GO_0043231 | Cellular component | intracellular membrane-bounded organelle |
| GO_0031965 | Cellular component | nuclear membrane |
| GO_0005901 | Cellular component | caveola |
| GO_0005634 | Cellular component | nucleus |
| GO_0004937 | Molecular function | alpha1-adrenergic receptor activity |
| GO_0046982 | Molecular function | protein heterodimerization activity |
| GO_0005515 | Molecular function | protein binding |
| Gene name | ADRA1A |
| Protein name | Alpha-1A adrenergic receptor (Alpha-1A adrenoreceptor) (Alpha-1A adrenoceptor) (Alpha-1C adrenergic receptor) (Alpha-adrenergic receptor 1c) Alpha-1A adrenergic receptor (Alpha-1A adrenoreceptor) (Alpha-1C adrenergic receptor) |
| Synonyms | ADRA1C |
| Description | FUNCTION: This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine(PE)-stimulated ERK signaling in cardiac myocytes. . |
| Accessions | E7EW16 B0ZBD3 ENST00000380573.4 [P35348-1] ENST00000519229.5 ENST00000380572.3 [P35348-6] ENST00000380582.7 [P35348-3] ENST00000519096.5 [P35348-7] P35348 ENST00000521711.5 [P35348-7] ENST00000276393.8 [P35348-1] ENST00000354550.4 [P35348-4] ENST00000380586.5 [P35348-2] |
