I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| GABAergic neuron | 5 studies | 30% ± 12% | |
| retinal rod cell | 3 studies | 27% ± 10% | |
| endothelial cell | 3 studies | 39% ± 5% | |
| interneuron | 3 studies | 42% ± 21% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| GABAergic neuron | 5 studies | 30% ± 12% | |
| retinal rod cell | 3 studies | 27% ± 10% | |
| endothelial cell | 3 studies | 39% ± 5% | |
| interneuron | 3 studies | 42% ± 21% |
Insufficient scRNA-seq data for expression of TACR1 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| prostate | 97% | 374.03 | 237 / 245 | 69% | 1.94 | 344 / 502 |
| breast | 99% | 1261.65 | 455 / 459 | 48% | 2.12 | 536 / 1118 |
| brain | 58% | 251.89 | 1520 / 2642 | 77% | 6.80 | 541 / 705 |
| uterus | 100% | 885.63 | 170 / 170 | 22% | 0.76 | 100 / 459 |
| bladder | 100% | 475.71 | 21 / 21 | 16% | 0.51 | 79 / 504 |
| esophagus | 94% | 306.82 | 1353 / 1445 | 19% | 0.48 | 35 / 183 |
| adipose | 99% | 1126.62 | 1195 / 1204 | 0% | 0 | 0 / 0 |
| kidney | 75% | 152.92 | 67 / 89 | 22% | 0.60 | 200 / 901 |
| ovary | 43% | 113.73 | 77 / 180 | 47% | 3.59 | 203 / 430 |
| lung | 54% | 133.94 | 311 / 578 | 29% | 1.10 | 339 / 1155 |
| blood vessel | 83% | 302.20 | 1103 / 1335 | 0% | 0 | 0 / 0 |
| intestine | 73% | 204.08 | 710 / 966 | 8% | 0.20 | 43 / 527 |
| skin | 71% | 352.93 | 1292 / 1809 | 10% | 0.26 | 48 / 472 |
| thymus | 50% | 124.98 | 327 / 653 | 11% | 0.18 | 67 / 605 |
| stomach | 38% | 99.58 | 138 / 359 | 13% | 0.75 | 37 / 286 |
| pancreas | 2% | 2.36 | 5 / 328 | 33% | 0.97 | 59 / 178 |
| adrenal gland | 21% | 27.47 | 54 / 258 | 13% | 0.26 | 31 / 230 |
| lymph node | 0% | 0 | 0 / 0 | 24% | 0.41 | 7 / 29 |
| muscle | 15% | 26.38 | 120 / 803 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 11% | 0.18 | 5 / 45 |
| liver | 0% | 0.45 | 1 / 226 | 4% | 0.51 | 15 / 406 |
| peripheral blood | 4% | 8.05 | 33 / 929 | 0% | 0 | 0 / 0 |
| heart | 3% | 7.64 | 30 / 861 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 1% | 0.02 | 1 / 80 |
| spleen | 0% | 0.36 | 1 / 241 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0032355 | Biological process | response to estradiol |
| GO_0010996 | Biological process | response to auditory stimulus |
| GO_0006954 | Biological process | inflammatory response |
| GO_0007200 | Biological process | phospholipase C-activating G protein-coupled receptor signaling pathway |
| GO_0045777 | Biological process | positive regulation of blood pressure |
| GO_1902093 | Biological process | positive regulation of flagellated sperm motility |
| GO_0051496 | Biological process | positive regulation of stress fiber assembly |
| GO_0007217 | Biological process | tachykinin receptor signaling pathway |
| GO_0051602 | Biological process | response to electrical stimulus |
| GO_0007616 | Biological process | long-term memory |
| GO_0002118 | Biological process | aggressive behavior |
| GO_0010193 | Biological process | response to ozone |
| GO_0045907 | Biological process | positive regulation of vasoconstriction |
| GO_0008306 | Biological process | associative learning |
| GO_0042713 | Biological process | sperm ejaculation |
| GO_0045471 | Biological process | response to ethanol |
| GO_0014910 | Biological process | regulation of smooth muscle cell migration |
| GO_0048660 | Biological process | regulation of smooth muscle cell proliferation |
| GO_0045760 | Biological process | positive regulation of action potential |
| GO_0050679 | Biological process | positive regulation of epithelial cell proliferation |
| GO_0007204 | Biological process | positive regulation of cytosolic calcium ion concentration |
| GO_0050671 | Biological process | positive regulation of lymphocyte proliferation |
| GO_0070474 | Biological process | positive regulation of uterine smooth muscle contraction |
| GO_0042755 | Biological process | eating behavior |
| GO_0035094 | Biological process | response to nicotine |
| GO_0003051 | Biological process | angiotensin-mediated drinking behavior |
| GO_0002687 | Biological process | positive regulation of leukocyte migration |
| GO_0035106 | Biological process | operant conditioning |
| GO_0048266 | Biological process | behavioral response to pain |
| GO_0032224 | Biological process | positive regulation of synaptic transmission, cholinergic |
| GO_0045778 | Biological process | positive regulation of ossification |
| GO_0032230 | Biological process | positive regulation of synaptic transmission, GABAergic |
| GO_0046887 | Biological process | positive regulation of hormone secretion |
| GO_0032570 | Biological process | response to progesterone |
| GO_0009582 | Biological process | detection of abiotic stimulus |
| GO_0010634 | Biological process | positive regulation of epithelial cell migration |
| GO_0060083 | Biological process | smooth muscle contraction involved in micturition |
| GO_0043117 | Biological process | positive regulation of vascular permeability |
| GO_0061827 | Cellular component | sperm head |
| GO_0036126 | Cellular component | sperm flagellum |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0030425 | Cellular component | dendrite |
| GO_0009986 | Cellular component | cell surface |
| GO_0044297 | Cellular component | cell body |
| GO_0097225 | Cellular component | sperm midpiece |
| GO_0016496 | Molecular function | substance P receptor activity |
| GO_0004995 | Molecular function | tachykinin receptor activity |
| GO_0005515 | Molecular function | protein binding |
| Gene name | TACR1 |
| Protein name | Substance-P receptor (SPR) (NK-1 receptor) (NK-1R) (Tachykinin receptor 1) Substance-P receptor (NK-1 receptor) (Tachykinin receptor 1) |
| Synonyms | NK1R TAC1R |
| Description | FUNCTION: This is a receptor for the tachykinin neuropeptide substance P. It is probably associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this receptor to tachykinins is: substance P > substance K > neuromedin-K. |
| Accessions | ENST00000305249.10 [P25103-1] Q4VBL8 Q53TR1 ENST00000409848.3 [P25103-3] P25103 Q53TQ2 |
