GPR143 | OmnibusX

Name	Number of supported studies	Average coverage
melanocyte	3 studies	43% ± 19%	Explore

sc-RNAseq data

Insufficient scRNA-seq data for expression of GPR143 at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
prostate	93%	123.98	227 / 245	96%	7.59	480 / 502
ovary	97%	220.82	175 / 180	82%	11.59	351 / 430
thymus	97%	109.79	635 / 653	73%	6.32	439 / 605
kidney	100%	358.08	89 / 89	64%	29.38	578 / 901
uterus	88%	145.17	149 / 170	72%	9.51	332 / 459
skin	72%	176.92	1298 / 1809	86%	236.93	408 / 472
lung	90%	81.01	521 / 578	58%	5.63	669 / 1155
pancreas	73%	46.40	240 / 328	66%	5.42	117 / 178
breast	53%	52.21	241 / 459	76%	8.42	855 / 1118
brain	98%	380.02	2584 / 2642	21%	1.18	151 / 705
adrenal gland	85%	76.01	220 / 258	21%	2.15	48 / 230
eye	0%	0	0 / 0	100%	521.73	80 / 80
stomach	42%	24.07	152 / 359	54%	8.92	155 / 286
bladder	38%	29.90	8 / 21	56%	7.47	283 / 504
intestine	24%	16.85	229 / 966	64%	9.13	339 / 527
liver	46%	25.87	103 / 226	34%	3.31	137 / 406
esophagus	38%	58.55	554 / 1445	33%	2.75	60 / 183
tonsil	0%	0	0 / 0	67%	5.20	30 / 45
adipose	22%	18.40	268 / 1204	0%	0	0 / 0
lymph node	0%	0	0 / 0	7%	1.86	2 / 29
heart	2%	1.28	18 / 861	0%	0	0 / 0
blood vessel	1%	0.56	13 / 1335	0%	0	0 / 0
peripheral blood	1%	0.47	7 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
muscle	0%	0	0 / 803	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
spleen	0%	0	0 / 241	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

GO_0007601	Biological process	visual perception
GO_0007218	Biological process	neuropeptide signaling pathway
GO_0007200	Biological process	phospholipase C-activating G protein-coupled receptor signaling pathway
GO_1902908	Biological process	regulation of melanosome transport
GO_0032400	Biological process	melanosome localization
GO_0007165	Biological process	signal transduction
GO_0032438	Biological process	melanosome organization
GO_0032402	Biological process	melanosome transport
GO_0007186	Biological process	G protein-coupled receptor signaling pathway
GO_0050848	Biological process	regulation of calcium-mediated signaling
GO_1903056	Biological process	regulation of melanosome organization
GO_0006726	Biological process	eye pigment biosynthetic process
GO_0016324	Cellular component	apical plasma membrane
GO_0005886	Cellular component	plasma membrane
GO_0016020	Cellular component	membrane
GO_0005794	Cellular component	Golgi apparatus
GO_0033162	Cellular component	melanosome membrane
GO_0005737	Cellular component	cytoplasm
GO_0042470	Cellular component	melanosome
GO_0005765	Cellular component	lysosomal membrane
GO_0004930	Molecular function	G protein-coupled receptor activity
GO_0035643	Molecular function	L-DOPA receptor activity
GO_0072544	Molecular function	L-DOPA binding
GO_0072545	Molecular function	L-tyrosine binding
GO_0035240	Molecular function	dopamine binding
GO_0005515	Molecular function	protein binding

Gene name	GPR143
Protein name	G protein-coupled receptor 143 G-protein coupled receptor 143 G-protein coupled receptor 143 (Ocular albinism type 1 protein)
Synonyms	OA1
Description	FUNCTION: Receptor for tyrosine, L-DOPA and dopamine. After binding to L-DOPA, stimulates Ca(2+) influx into the cytoplasm, increases secretion of the neurotrophic factor SERPINF1 and relocalizes beta arrestin at the plasma membrane; this ligand-dependent signaling occurs through a G(q)-mediated pathway in melanocytic cells. Its activity is mediated by G proteins which activate the phosphoinositide signaling pathway. Also plays a role as an intracellular G protein-coupled receptor involved in melanosome biogenesis, organization and transport. .
Accessions	C9J9N1 P51810 A0A5J6CXI4 H7BZN6 ENST00000467482.6 A0A5J6CXM9 ENST00000431126.1 ENST00000447366.5

GPR143 report