OPRL1 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of OPRL1 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of OPRL1 at tissue level.

III. Associated gene sets

GO_0019233Biological processsensory perception of pain
GO_0044849Biological processestrous cycle
GO_0032355Biological processresponse to estradiol
GO_0007218Biological processneuropeptide signaling pathway
GO_0007200Biological processphospholipase C-activating G protein-coupled receptor signaling pathway
GO_1990708Biological processconditioned place preference
GO_0019722Biological processcalcium-mediated signaling
GO_0007600Biological processsensory perception
GO_1904059Biological processregulation of locomotor rhythm
GO_0045776Biological processnegative regulation of blood pressure
GO_0007193Biological processadenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
GO_0042755Biological processeating behavior
GO_0043951Biological processnegative regulation of cAMP-mediated signaling
GO_0106072Biological processnegative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway
GO_0038003Biological processG protein-coupled opioid receptor signaling pathway
GO_0035810Biological processpositive regulation of urine volume
GO_0005886Cellular componentplasma membrane
GO_0031410Cellular componentcytoplasmic vesicle
GO_0043005Cellular componentneuron projection
GO_0004930Molecular functionG protein-coupled receptor activity
GO_0042923Molecular functionneuropeptide binding
GO_0001626Molecular functionnociceptin receptor activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameOPRL1
Protein nameNociceptin receptor (Kappa-type 3 opioid receptor) (KOR-3) (Orphanin FQ receptor)
Nociceptin receptor (Kappa-type 3 opioid receptor) (Orphanin FQ receptor)
SynonymsNOP
OOR
ORL1
KOR3
OPRL
DescriptionFUNCTION: G-protein coupled opioid receptor that functions as a receptor for the endogenous neuropeptide nociceptin. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling via G proteins mediates inhibition of adenylate cyclase activity and calcium channel activity. Arrestins modulate signaling via G proteins and mediate the activation of alternative signaling pathways that lead to the activation of MAP kinases. Plays a role in modulating nociception and the perception of pain. Plays a role in the regulation of locomotor activity by the neuropeptide nociceptin. .

FUNCTION: G-protein coupled opioid receptor that functions as a receptor for the endogenous neuropeptide nociceptin. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling via G proteins mediates inhibition of adenylate cyclase activity and calcium channel activity. Arrestins modulate signaling via G proteins and mediate the activation of alternative signaling pathways that lead to the activation of MAP kinases. Plays a role in modulating nociception and the perception of pain. Plays a role in the regulation of locomotor activity by the neuropeptide nociceptin. .

FUNCTION: G-protein coupled opioid receptor that functions as a receptor for the endogenous neuropeptide nociceptin. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling via G proteins mediates inhibition of adenylate cyclase activity and calcium channel activity. Arrestins modulate signaling via G proteins and mediate the activation of alternative signaling pathways that lead to the activation of MAP kinases. Plays a role in modulating nociception and the perception of pain. Plays a role in the regulation of locomotor activity by the neuropeptide nociceptin. .

FUNCTION: G-protein coupled opioid receptor that functions as a receptor for the endogenous neuropeptide nociceptin. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling via G proteins mediates inhibition of adenylate cyclase activity and calcium channel activity. Arrestins modulate signaling via G proteins and mediate the activation of alternative signaling pathways that lead to the activation of MAP kinases. Plays a role in modulating nociception and the perception of pain. Plays a role in the regulation of locomotor activity by the neuropeptide nociceptin. .

FUNCTION: G-protein coupled opioid receptor that functions as a receptor for the endogenous neuropeptide nociceptin. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling via G proteins mediates inhibition of adenylate cyclase activity and calcium channel activity. Arrestins modulate signaling via G proteins and mediate the activation of alternative signaling pathways that lead to the activation of MAP kinases. Plays a role in modulating nociception and the perception of pain. Plays a role in the regulation of locomotor activity by the neuropeptide nociceptin. .

FUNCTION: G-protein coupled opioid receptor that functions as a receptor for the endogenous neuropeptide nociceptin. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling via G proteins mediates inhibition of adenylate cyclase activity and calcium channel activity. Arrestins modulate signaling via G proteins and mediate the activation of alternative signaling pathways that lead to the activation of MAP kinases. Plays a role in modulating nociception and the perception of pain. Plays a role in the regulation of locomotor activity by the neuropeptide nociceptin. .

FUNCTION: G-protein coupled opioid receptor that functions as a receptor for the endogenous neuropeptide nociceptin. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling via G proteins mediates inhibition of adenylate cyclase activity and calcium channel activity. Arrestins modulate signaling via G proteins and mediate the activation of alternative signaling pathways that lead to the activation of MAP kinases. Plays a role in modulating nociception and the perception of pain. Plays a role in the regulation of locomotor activity by the neuropeptide nociceptin. .

AccessionsENST00000625570.1
ENST00000672146.3
A0A6H0W9J6
Q6FGM5
ENST00000336866.7 [P41146-1]
ENST00000615600.3
A0A0G2JQE4
A0A5F9ZI64
P41146
A0A6H0WF25
ENST00000627060.2
A0A6H0WB77
ENST00000349451.3 [P41146-1]
ENST00000355631.8 [P41146-1]