EDN1 | OmnibusX

Name	Number of supported studies	Average coverage
endothelial cell	24 studies	29% ± 10%	Explore
endothelial cell of artery	12 studies	46% ± 18%	Explore
capillary endothelial cell	11 studies	32% ± 16%	Explore
vein endothelial cell	9 studies	35% ± 22%	Explore
basal cell	8 studies	27% ± 11%	Explore
endothelial cell of vascular tree	7 studies	24% ± 8%	Explore
epithelial cell	7 studies	32% ± 18%	Explore
type I pneumocyte	6 studies	30% ± 12%	Explore
secretory cell	6 studies	17% ± 1%	Explore
luminal cell of prostate epithelium	3 studies	23% ± 2%	Explore
pancreatic ductal cell	3 studies	39% ± 13%	Explore

Name	Number of supported studies	Average coverage
prostate	3 studies	26% ± 6%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
lung	100%	3693.29	576 / 578	89%	38.20	1031 / 1155
intestine	96%	923.16	926 / 966	90%	34.09	472 / 527
stomach	95%	793.24	342 / 359	85%	33.01	244 / 286
breast	100%	2503.02	458 / 459	73%	21.31	812 / 1118
esophagus	83%	731.36	1194 / 1445	88%	21.87	161 / 183
kidney	90%	650.04	80 / 89	78%	73.00	700 / 901
brain	82%	736.49	2179 / 2642	83%	21.29	585 / 705
pancreas	72%	372.10	236 / 328	92%	34.41	164 / 178
uterus	91%	623.68	155 / 170	69%	19.12	316 / 459
prostate	87%	554.00	214 / 245	61%	13.30	308 / 502
bladder	81%	463.43	17 / 21	66%	21.24	333 / 504
spleen	100%	988.38	240 / 241	0%	0	0 / 0
adipose	99%	3199.07	1195 / 1204	0%	0	0 / 0
ovary	31%	182.39	56 / 180	66%	16.72	284 / 430
blood vessel	86%	969.33	1150 / 1335	0%	0	0 / 0
skin	78%	845.54	1419 / 1809	7%	0.83	34 / 472
thymus	55%	308.81	358 / 653	27%	3.69	162 / 605
tonsil	0%	0	0 / 0	73%	14.82	33 / 45
heart	68%	424.19	588 / 861	0%	0	0 / 0
muscle	60%	398.86	482 / 803	0%	0	0 / 0
adrenal gland	24%	86.45	63 / 258	14%	2.05	32 / 230
liver	8%	30.45	19 / 226	18%	3.86	75 / 406
lymph node	0%	0	0 / 0	17%	2.01	5 / 29
peripheral blood	17%	174.73	157 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
eye	0%	0	0 / 0	0%	0	0 / 80
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0046888	Biological process	negative regulation of hormone secretion
GO_0033574	Biological process	response to testosterone
GO_0006366	Biological process	transcription by RNA polymerase II
GO_0071560	Biological process	cellular response to transforming growth factor beta stimulus
GO_1901224	Biological process	positive regulation of non-canonical NF-kappaB signal transduction
GO_0060298	Biological process	positive regulation of sarcomere organization
GO_0071389	Biological process	cellular response to mineralocorticoid stimulus
GO_0061051	Biological process	positive regulation of cell growth involved in cardiac muscle cell development
GO_0060385	Biological process	axonogenesis involved in innervation
GO_0030878	Biological process	thyroid gland development
GO_0006874	Biological process	intracellular calcium ion homeostasis
GO_0006885	Biological process	regulation of pH
GO_0014823	Biological process	response to activity
GO_0007267	Biological process	cell-cell signaling
GO_0042313	Biological process	protein kinase C deactivation
GO_0035050	Biological process	embryonic heart tube development
GO_0001516	Biological process	prostaglandin biosynthetic process
GO_0035094	Biological process	response to nicotine
GO_0035815	Biological process	positive regulation of renal sodium excretion
GO_0014824	Biological process	artery smooth muscle contraction
GO_0043491	Biological process	phosphatidylinositol 3-kinase/protein kinase B signal transduction
GO_0042310	Biological process	vasoconstriction
GO_1904707	Biological process	positive regulation of vascular associated smooth muscle cell proliferation
GO_0060585	Biological process	positive regulation of prostaglandin-endoperoxide synthase activity
GO_0070301	Biological process	cellular response to hydrogen peroxide
GO_1903537	Biological process	meiotic cell cycle process involved in oocyte maturation
GO_0007166	Biological process	cell surface receptor signaling pathway
GO_0007585	Biological process	respiratory gaseous exchange by respiratory system
GO_0070294	Biological process	renal sodium ion absorption
GO_2001259	Biological process	positive regulation of cation channel activity
GO_0071466	Biological process	cellular response to xenobiotic stimulus
GO_0043200	Biological process	response to amino acid
GO_0070101	Biological process	positive regulation of chemokine-mediated signaling pathway
GO_0001701	Biological process	in utero embryonic development
GO_0042482	Biological process	positive regulation of odontogenesis
GO_0071372	Biological process	cellular response to follicle-stimulating hormone stimulus
GO_0010629	Biological process	negative regulation of gene expression
GO_2000273	Biological process	positive regulation of signaling receptor activity
GO_0010193	Biological process	response to ozone
GO_0030593	Biological process	neutrophil chemotaxis
GO_0010737	Biological process	protein kinase A signaling
GO_0071347	Biological process	cellular response to interleukin-1
GO_0072011	Biological process	glomerular endothelium development
GO_0071277	Biological process	cellular response to calcium ion
GO_0097492	Biological process	sympathetic neuron axon guidance
GO_0007589	Biological process	body fluid secretion
GO_0007186	Biological process	G protein-coupled receptor signaling pathway
GO_0070371	Biological process	ERK1 and ERK2 cascade
GO_0045429	Biological process	positive regulation of nitric oxide biosynthetic process
GO_0032308	Biological process	positive regulation of prostaglandin secretion
GO_0042474	Biological process	middle ear morphogenesis
GO_0030185	Biological process	nitric oxide transport
GO_0031583	Biological process	phospholipase D-activating G protein-coupled receptor signaling pathway
GO_0051216	Biological process	cartilage development
GO_0010460	Biological process	positive regulation of heart rate
GO_0070588	Biological process	calcium ion transmembrane transport
GO_0086101	Biological process	endothelin receptor signaling pathway involved in heart process
GO_0007205	Biological process	protein kinase C-activating G protein-coupled receptor signaling pathway
GO_0003100	Biological process	regulation of systemic arterial blood pressure by endothelin
GO_0051899	Biological process	membrane depolarization
GO_0019722	Biological process	calcium-mediated signaling
GO_0051091	Biological process	positive regulation of DNA-binding transcription factor activity
GO_0042554	Biological process	superoxide anion generation
GO_0014034	Biological process	neural crest cell fate commitment
GO_0048661	Biological process	positive regulation of smooth muscle cell proliferation
GO_0003357	Biological process	noradrenergic neuron differentiation
GO_0034392	Biological process	negative regulation of smooth muscle cell apoptotic process
GO_0042045	Biological process	epithelial fluid transport
GO_0043406	Biological process	positive regulation of MAP kinase activity
GO_1902074	Biological process	response to salt
GO_0071548	Biological process	response to dexamethasone
GO_0051248	Biological process	negative regulation of protein metabolic process
GO_0001569	Biological process	branching involved in blood vessel morphogenesis
GO_0045987	Biological process	positive regulation of smooth muscle contraction
GO_0007005	Biological process	mitochondrion organization
GO_0007204	Biological process	positive regulation of cytosolic calcium ion concentration
GO_0007193	Biological process	adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
GO_0030072	Biological process	peptide hormone secretion
GO_0034696	Biological process	response to prostaglandin F
GO_0090023	Biological process	positive regulation of neutrophil chemotaxis
GO_0048675	Biological process	axon extension
GO_0008284	Biological process	positive regulation of cell population proliferation
GO_0030195	Biological process	negative regulation of blood coagulation
GO_0001975	Biological process	response to amphetamine
GO_0071385	Biological process	cellular response to glucocorticoid stimulus
GO_0003253	Biological process	cardiac neural crest cell migration involved in outflow tract morphogenesis
GO_0046887	Biological process	positive regulation of hormone secretion
GO_0035810	Biological process	positive regulation of urine volume
GO_0043179	Biological process	rhythmic excitation
GO_0045944	Biological process	positive regulation of transcription by RNA polymerase II
GO_0071346	Biological process	cellular response to type II interferon
GO_0071398	Biological process	cellular response to fatty acid
GO_0043507	Biological process	positive regulation of JUN kinase activity
GO_0035994	Biological process	response to muscle stretch
GO_0072112	Biological process	podocyte differentiation
GO_0007200	Biological process	phospholipase C-activating G protein-coupled receptor signaling pathway
GO_0050850	Biological process	positive regulation of calcium-mediated signaling
GO_0044321	Biological process	response to leptin
GO_0019229	Biological process	regulation of vasoconstriction
GO_0003094	Biological process	glomerular filtration
GO_1905653	Biological process	positive regulation of artery morphogenesis
GO_0001821	Biological process	histamine secretion
GO_0010613	Biological process	positive regulation of cardiac muscle hypertrophy
GO_0071373	Biological process	cellular response to luteinizing hormone stimulus
GO_0010595	Biological process	positive regulation of endothelial cell migration
GO_0060137	Biological process	maternal process involved in parturition
GO_0000122	Biological process	negative regulation of transcription by RNA polymerase II
GO_0045321	Biological process	leukocyte activation
GO_0051771	Biological process	negative regulation of nitric-oxide synthase biosynthetic process
GO_0060070	Biological process	canonical Wnt signaling pathway
GO_0044751	Biological process	cellular response to human chorionic gonadotropin stimulus
GO_0009953	Biological process	dorsal/ventral pattern formation
GO_1902287	Biological process	semaphorin-plexin signaling pathway involved in axon guidance
GO_0071356	Biological process	cellular response to tumor necrosis factor
GO_0030335	Biological process	positive regulation of cell migration
GO_0043123	Biological process	positive regulation of canonical NF-kappaB signal transduction
GO_0086100	Biological process	endothelin receptor signaling pathway
GO_0045793	Biological process	positive regulation of cell size
GO_0014826	Biological process	vein smooth muscle contraction
GO_0061626	Biological process	pharyngeal arch artery morphogenesis
GO_0045840	Biological process	positive regulation of mitotic nuclear division
GO_0032496	Biological process	response to lipopolysaccharide
GO_1900182	Biological process	positive regulation of protein localization to nucleus
GO_0010827	Biological process	regulation of glucose transmembrane transport
GO_0071456	Biological process	cellular response to hypoxia
GO_0045178	Cellular component	basal part of cell
GO_0048237	Cellular component	rough endoplasmic reticulum lumen
GO_0005576	Cellular component	extracellular region
GO_0005615	Cellular component	extracellular space
GO_0033093	Cellular component	Weibel-Palade body
GO_0005737	Cellular component	cytoplasm
GO_0030133	Cellular component	transport vesicle
GO_0031708	Molecular function	endothelin B receptor binding
GO_0005179	Molecular function	hormone activity
GO_0005125	Molecular function	cytokine activity
GO_0031707	Molecular function	endothelin A receptor binding
GO_0005515	Molecular function	protein binding

Gene name	EDN1
Protein name	Endothelin-1 (Preproendothelin-1) (PPET1) [Cleaved into: Endothelin-1 (ET-1); Big endothelin-1] Endothelin-1
Synonyms	hCG_37405
Description	FUNCTION: Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells . Also binds the DEAR/FBXW7-AS1 receptor . Promotes mesenteric arterial wall remodeling via activation of ROCK signaling and subsequent colocalization of NFATC3 with F-actin filaments (By similarity). NFATC3 then translocates to the nucleus where it subsequently promotes the transcription of the smooth muscle hypertrophy and differentiation marker ACTA2 (By similarity). .
Accessions	P05305 ENST00000379375.6 Q6FH53

EDN1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review