C5AR1 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
macrophage	39 studies	44% ± 19%	Explore
classical monocyte	27 studies	51% ± 15%	Explore
non-classical monocyte	26 studies	62% ± 16%	Explore
monocyte	23 studies	38% ± 18%	Explore
myeloid cell	15 studies	37% ± 17%	Explore
neutrophil	13 studies	52% ± 16%	Explore
ciliated cell	11 studies	26% ± 9%	Explore
alveolar macrophage	8 studies	41% ± 14%	Explore
dendritic cell	6 studies	39% ± 16%	Explore
mononuclear phagocyte	6 studies	37% ± 14%	Explore
conventional dendritic cell	6 studies	32% ± 10%	Explore
intermediate monocyte	6 studies	49% ± 23%	Explore
leukocyte	4 studies	26% ± 4%	Explore
tissue-resident macrophage	3 studies	47% ± 7%	Explore
inflammatory macrophage	3 studies	27% ± 6%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	5 studies	20% ± 4%	Explore
lung	3 studies	30% ± 15%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
lung	100%	5456.39	578 / 578	97%	27.36	1119 / 1155
kidney	73%	961.40	65 / 89	97%	26.04	872 / 901
breast	70%	970.34	320 / 459	97%	17.40	1079 / 1118
intestine	76%	906.66	735 / 966	85%	16.16	449 / 527
uterus	64%	676.80	109 / 170	88%	14.06	406 / 459
bladder	76%	757.95	16 / 21	75%	14.63	380 / 504
adrenal gland	86%	1125.59	223 / 258	62%	11.20	142 / 230
ovary	49%	485.92	89 / 180	91%	17.58	393 / 430
liver	70%	1102.51	158 / 226	68%	7.72	276 / 406
stomach	45%	642.43	163 / 359	90%	21.15	257 / 286
prostate	59%	575.48	144 / 245	73%	7.31	368 / 502
esophagus	35%	370.05	504 / 1445	91%	18.48	167 / 183
pancreas	20%	155.33	64 / 328	97%	28.70	172 / 178
thymus	40%	317.15	260 / 653	74%	8.59	450 / 605
spleen	100%	4696.54	240 / 241	0%	0	0 / 0
brain	18%	215.86	463 / 2642	79%	20.35	555 / 705
adipose	94%	3035.16	1127 / 1204	0%	0	0 / 0
lymph node	0%	0	0 / 0	93%	30.03	27 / 29
blood vessel	93%	2140.82	1241 / 1335	0%	0	0 / 0
skin	15%	163.68	270 / 1809	76%	12.06	361 / 472
tonsil	0%	0	0 / 0	89%	11.99	40 / 45
peripheral blood	82%	28270.64	763 / 929	0%	0	0 / 0
heart	50%	632.35	432 / 861	0%	0	0 / 0
eye	0%	0	0 / 0	11%	0.64	9 / 80
muscle	2%	11.44	13 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0006954	Biological process	inflammatory response
GO_0007200	Biological process	phospholipase C-activating G protein-coupled receptor signaling pathway
GO_0001774	Biological process	microglial cell activation
GO_0045766	Biological process	positive regulation of angiogenesis
GO_0048143	Biological process	astrocyte activation
GO_0007165	Biological process	signal transduction
GO_0030593	Biological process	neutrophil chemotaxis
GO_0006935	Biological process	chemotaxis
GO_0006968	Biological process	cellular defense response
GO_0038178	Biological process	complement component C5a signaling pathway
GO_0010759	Biological process	positive regulation of macrophage chemotaxis
GO_0032494	Biological process	response to peptidoglycan
GO_0097242	Biological process	amyloid-beta clearance
GO_0006955	Biological process	immune response
GO_0050679	Biological process	positive regulation of epithelial cell proliferation
GO_0050830	Biological process	defense response to Gram-positive bacterium
GO_0007204	Biological process	positive regulation of cytosolic calcium ion concentration
GO_1902947	Biological process	regulation of tau-protein kinase activity
GO_0007606	Biological process	sensory perception of chemical stimulus
GO_0010575	Biological process	positive regulation of vascular endothelial growth factor production
GO_0042789	Biological process	mRNA transcription by RNA polymerase II
GO_0090023	Biological process	positive regulation of neutrophil chemotaxis
GO_0050890	Biological process	cognition
GO_0099172	Biological process	presynapse organization
GO_0070374	Biological process	positive regulation of ERK1 and ERK2 cascade
GO_0002430	Biological process	complement receptor mediated signaling pathway
GO_0030667	Cellular component	secretory granule membrane
GO_0005886	Cellular component	plasma membrane
GO_0045177	Cellular component	apical part of cell
GO_0016323	Cellular component	basolateral plasma membrane
GO_0004930	Molecular function	G protein-coupled receptor activity
GO_0004878	Molecular function	complement component C5a receptor activity

IV. Literature review

[source]

Gene name	C5AR1
Protein name	Complement C5a receptor 1 C5a anaphylatoxin chemotactic receptor 1 (C5a anaphylatoxin chemotactic receptor) (C5a-R) (C5aR) (CD antigen CD88)
Synonyms	C5R1 C5AR
Description	FUNCTION: Receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a . The ligand interacts with at least two sites on the receptor: a high-affinity site on the extracellular N-terminus, and a second site in the transmembrane region which activates downstream signaling events . Receptor activation stimulates chemotaxis, granule enzyme release, intracellular calcium release and superoxide anion production . .
Accessions	ENST00000355085.4 ENST00000594787.1 M0QZK7 P21730

C5AR1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review