I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| microglial cell | 13 studies | 52% ± 21% | |
| macrophage | 3 studies | 18% ± 3% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| microglial cell | 13 studies | 52% ± 21% | |
| macrophage | 3 studies | 18% ± 3% |
Insufficient scRNA-seq data for expression of P2RY12 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| brain | 92% | 575.09 | 2421 / 2642 | 99% | 78.16 | 699 / 705 |
| breast | 79% | 92.21 | 362 / 459 | 58% | 2.00 | 647 / 1118 |
| lung | 74% | 84.14 | 425 / 578 | 47% | 1.55 | 545 / 1155 |
| adrenal gland | 62% | 53.32 | 159 / 258 | 45% | 4.53 | 103 / 230 |
| intestine | 81% | 91.23 | 783 / 966 | 13% | 0.30 | 67 / 527 |
| adipose | 91% | 144.06 | 1094 / 1204 | 0% | 0 | 0 / 0 |
| spleen | 86% | 162.60 | 208 / 241 | 0% | 0 | 0 / 0 |
| bladder | 71% | 46.24 | 15 / 21 | 15% | 0.41 | 74 / 504 |
| thymus | 22% | 13.88 | 144 / 653 | 64% | 2.29 | 387 / 605 |
| kidney | 10% | 7.64 | 9 / 89 | 70% | 3.32 | 631 / 901 |
| lymph node | 0% | 0 | 0 / 0 | 79% | 7.96 | 23 / 29 |
| prostate | 40% | 30.60 | 97 / 245 | 39% | 0.76 | 195 / 502 |
| esophagus | 54% | 48.36 | 787 / 1445 | 10% | 0.24 | 18 / 183 |
| skin | 6% | 3.13 | 104 / 1809 | 46% | 1.83 | 218 / 472 |
| pancreas | 6% | 3.39 | 19 / 328 | 45% | 1.35 | 80 / 178 |
| stomach | 26% | 21.75 | 93 / 359 | 24% | 0.50 | 68 / 286 |
| blood vessel | 48% | 46.76 | 637 / 1335 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 42% | 0.96 | 19 / 45 |
| ovary | 15% | 8.28 | 27 / 180 | 23% | 0.57 | 101 / 430 |
| peripheral blood | 38% | 34.43 | 352 / 929 | 0% | 0 | 0 / 0 |
| uterus | 21% | 12.09 | 36 / 170 | 11% | 0.25 | 51 / 459 |
| heart | 29% | 20.03 | 249 / 861 | 0% | 0 | 0 / 0 |
| liver | 6% | 3.41 | 13 / 226 | 9% | 0.22 | 35 / 406 |
| eye | 0% | 0 | 0 / 0 | 8% | 0.13 | 6 / 80 |
| muscle | 1% | 0.41 | 7 / 803 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0033630 | Biological process | positive regulation of cell adhesion mediated by integrin |
| GO_0150063 | Biological process | visual system development |
| GO_1904141 | Biological process | positive regulation of microglial cell migration |
| GO_0007200 | Biological process | phospholipase C-activating G protein-coupled receptor signaling pathway |
| GO_0019722 | Biological process | calcium-mediated signaling |
| GO_0070527 | Biological process | platelet aggregation |
| GO_0050921 | Biological process | positive regulation of chemotaxis |
| GO_0030032 | Biological process | lamellipodium assembly |
| GO_0006811 | Biological process | monoatomic ion transport |
| GO_0001973 | Biological process | G protein-coupled adenosine receptor signaling pathway |
| GO_0048678 | Biological process | response to axon injury |
| GO_1900029 | Biological process | positive regulation of ruffle assembly |
| GO_0043270 | Biological process | positive regulation of monoatomic ion transport |
| GO_0030030 | Biological process | cell projection organization |
| GO_0051649 | Biological process | establishment of localization in cell |
| GO_0071318 | Biological process | cellular response to ATP |
| GO_0030168 | Biological process | platelet activation |
| GO_0007599 | Biological process | hemostasis |
| GO_1904139 | Biological process | regulation of microglial cell migration |
| GO_0007186 | Biological process | G protein-coupled receptor signaling pathway |
| GO_0006930 | Biological process | substrate-dependent cell migration, cell extension |
| GO_0007193 | Biological process | adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway |
| GO_0050920 | Biological process | regulation of chemotaxis |
| GO_0035589 | Biological process | G protein-coupled purinergic nucleotide receptor signaling pathway |
| GO_0051897 | Biological process | positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction |
| GO_0033626 | Biological process | positive regulation of integrin activation by cell surface receptor linked signal transduction |
| GO_0021801 | Biological process | cerebral cortex radial glia-guided migration |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0016020 | Cellular component | membrane |
| GO_0009986 | Cellular component | cell surface |
| GO_0044298 | Cellular component | cell body membrane |
| GO_0031253 | Cellular component | cell projection membrane |
| GO_0005085 | Molecular function | guanyl-nucleotide exchange factor activity |
| GO_0045028 | Molecular function | G protein-coupled purinergic nucleotide receptor activity |
| GO_0001621 | Molecular function | G protein-coupled ADP receptor activity |
| GO_0001609 | Molecular function | G protein-coupled adenosine receptor activity |
| Gene name | P2RY12 |
| Protein name | P2Y purinoceptor 12 (P2Y12) (ADP-glucose receptor) (ADPG-R) (P2T(AC)) (P2Y(AC)) (P2Y(cyc)) (P2Y12 platelet ADP receptor) (P2Y(ADP)) (SP1999) Purinergic receptor P2Y G-protein coupled 12 transcript variant 1 |
| Synonyms | HORK3 |
| Description | FUNCTION: Receptor for ADP and ATP coupled to G-proteins that inhibit the adenylyl cyclase second messenger system. Not activated by UDP and UTP. Required for normal platelet aggregation and blood coagulation. . |
| Accessions | A0A2H4P6E7 ENST00000302632.4 Q9H244 |
