PTGDR2 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of PTGDR2 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of PTGDR2 at tissue level.

III. Associated gene sets

GO_0006955Biological processimmune response
GO_0007186Biological processG protein-coupled receptor signaling pathway
GO_0007218Biological processneuropeptide signaling pathway
GO_0006935Biological processchemotaxis
GO_0007193Biological processadenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
GO_0019722Biological processcalcium-mediated signaling
GO_0045745Biological processpositive regulation of G protein-coupled receptor signaling pathway
GO_2000255Biological processnegative regulation of male germ cell proliferation
GO_0005886Cellular componentplasma membrane
GO_0043005Cellular componentneuron projection
GO_0004958Molecular functionprostaglandin F receptor activity
GO_0042923Molecular functionneuropeptide binding
GO_0004930Molecular functionG protein-coupled receptor activity
GO_0004956Molecular functionprostaglandin D receptor activity
GO_0001785Molecular functionprostaglandin J receptor activity

IV. Literature review

[source]
Gene namePTGDR2
Protein nameProstaglandin D2 receptor 2 (Chemoattractant receptor-homologous molecule expressed on Th2 cells) (G-protein coupled receptor 44) (CD antigen CD294)
SynonymsCRTH2
GPR44
DL1R
DescriptionFUNCTION: Receptor for prostaglandin D2 (PGD2). Coupled to the G(i)-protein. Receptor activation may result in pertussis toxin-sensitive decreases in cAMP levels and Ca(2+) mobilization. PI3K signaling is also implicated in mediating PTGDR2 effects. PGD2 induced receptor internalization. CRTH2 internalization can be regulated by diverse kinases such as, PKC, PKA, GRK2, GPRK5/GRK5 and GRK6. Receptor activation is responsible, at least in part, in immune regulation and allergic/inflammation responses. .

AccessionsENST00000332539.5
Q9Y5Y4