FZD2 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of FZD2 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of FZD2 at tissue level.

III. Associated gene sets

GO_0003151Biological processoutflow tract morphogenesis
GO_0051091Biological processpositive regulation of DNA-binding transcription factor activity
GO_0045446Biological processendothelial cell differentiation
GO_0003149Biological processmembranous septum morphogenesis
GO_0007608Biological processsensory perception of smell
GO_0090103Biological processcochlea morphogenesis
GO_0007267Biological processcell-cell signaling
GO_0060070Biological processcanonical Wnt signaling pathway
GO_0090179Biological processplanar cell polarity pathway involved in neural tube closure
GO_0030182Biological processneuron differentiation
GO_0003150Biological processmuscular septum morphogenesis
GO_0007186Biological processG protein-coupled receptor signaling pathway
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_0060022Biological processhard palate development
GO_0060119Biological processinner ear receptor cell development
GO_0060071Biological processWnt signaling pathway, planar cell polarity pathway
GO_0035567Biological processnon-canonical Wnt signaling pathway
GO_0016055Biological processWnt signaling pathway
GO_0005886Cellular componentplasma membrane
GO_0030669Cellular componentclathrin-coated endocytic vesicle membrane
GO_0005925Cellular componentfocal adhesion
GO_0005737Cellular componentcytoplasm
GO_0017147Molecular functionWnt-protein binding
GO_0004930Molecular functionG protein-coupled receptor activity
GO_0042813Molecular functionWnt receptor activity
GO_0030165Molecular functionPDZ domain binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameFZD2
Protein nameFrizzled-2
Frizzled-2 (Fz-2) (hFz2) (FzE2)
Synonyms
DescriptionFUNCTION: Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes . A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. .; FUNCTION: (Microbial infection) Acts as a receptor for C.difficile toxin TcdB in the colonic epithelium . TcdB occupies the binding site for Wnt-adducted palmitoleate in frizzled receptors and TcdB-binding prevents Wnt-binding and downstream Wnt signaling . .

AccessionsQ14332
ENST00000315323.5
Q86UZ8