Name | Number of supported studies | Average coverage | |
---|---|---|---|
glutamatergic neuron | 11 studies | 60% ± 22% | |
GABAergic neuron | 10 studies | 39% ± 17% | |
astrocyte | 10 studies | 35% ± 21% | |
endothelial cell | 10 studies | 31% ± 17% | |
smooth muscle cell | 8 studies | 53% ± 20% | |
interneuron | 6 studies | 40% ± 21% | |
cardiac muscle cell | 6 studies | 53% ± 20% | |
pericyte | 5 studies | 47% ± 20% | |
neuron | 4 studies | 27% ± 9% | |
oligodendrocyte precursor cell | 4 studies | 20% ± 4% | |
retinal ganglion cell | 4 studies | 32% ± 16% | |
GABAergic interneuron | 3 studies | 32% ± 8% | |
granule cell | 3 studies | 41% ± 23% | |
microglial cell | 3 studies | 39% ± 19% | |
mesothelial cell | 3 studies | 29% ± 7% | |
mast cell | 3 studies | 18% ± 2% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
thymus | 100% | 789.26 | 651 / 653 | 91% | 4.21 | 553 / 605 |
brain | 94% | 1024.52 | 2476 / 2642 | 88% | 7.46 | 622 / 705 |
breast | 99% | 787.83 | 453 / 459 | 13% | 0.28 | 147 / 1118 |
adipose | 99% | 890.73 | 1191 / 1204 | 0% | 0 | 0 / 0 |
heart | 96% | 1086.56 | 827 / 861 | 0% | 0 | 0 / 0 |
uterus | 72% | 251.95 | 122 / 170 | 13% | 0.34 | 60 / 459 |
ovary | 48% | 174.16 | 86 / 180 | 33% | 0.64 | 144 / 430 |
blood vessel | 66% | 667.39 | 885 / 1335 | 0% | 0 | 0 / 0 |
lung | 41% | 100.22 | 235 / 578 | 22% | 0.84 | 255 / 1155 |
spleen | 61% | 182.29 | 148 / 241 | 0% | 0 | 0 / 0 |
bladder | 33% | 86.76 | 7 / 21 | 23% | 0.53 | 116 / 504 |
kidney | 48% | 148.61 | 43 / 89 | 2% | 0.06 | 14 / 901 |
esophagus | 23% | 65.96 | 339 / 1445 | 21% | 0.57 | 39 / 183 |
intestine | 34% | 94.01 | 326 / 966 | 6% | 0.11 | 33 / 527 |
skin | 36% | 94.88 | 658 / 1809 | 3% | 0.08 | 13 / 472 |
peripheral blood | 23% | 51.97 | 216 / 929 | 0% | 0 | 0 / 0 |
muscle | 22% | 57.02 | 180 / 803 | 0% | 0 | 0 / 0 |
pancreas | 0% | 0 | 0 / 328 | 22% | 0.56 | 39 / 178 |
stomach | 10% | 23.65 | 36 / 359 | 8% | 0.18 | 24 / 286 |
prostate | 18% | 58.06 | 43 / 245 | 0% | 0.01 | 2 / 502 |
adrenal gland | 3% | 5.61 | 7 / 258 | 9% | 0.50 | 21 / 230 |
lymph node | 0% | 0 | 0 / 0 | 7% | 0.11 | 2 / 29 |
tonsil | 0% | 0 | 0 / 0 | 2% | 0.09 | 1 / 45 |
eye | 0% | 0 | 0 / 0 | 1% | 0.04 | 1 / 80 |
liver | 0% | 0.74 | 1 / 226 | 0% | 0.06 | 2 / 406 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
GO_0007186 | Biological process | G protein-coupled receptor signaling pathway |
GO_0035556 | Biological process | intracellular signal transduction |
GO_0008277 | Biological process | regulation of G protein-coupled receptor signaling pathway |
GO_0043547 | Biological process | positive regulation of GTPase activity |
GO_0009968 | Biological process | negative regulation of signal transduction |
GO_0005829 | Cellular component | cytosol |
GO_0005886 | Cellular component | plasma membrane |
GO_0043005 | Cellular component | neuron projection |
GO_0016020 | Cellular component | membrane |
GO_0005737 | Cellular component | cytoplasm |
GO_0005634 | Cellular component | nucleus |
GO_0005096 | Molecular function | GTPase activator activity |
GO_0005515 | Molecular function | protein binding |
GO_0003924 | Molecular function | GTPase activity |
Gene name | RGS6 |
Protein name | Regulator of G protein signaling 6 (cDNA FLJ51839, highly similar to Regulator of G-protein signaling 6) Regulator of G protein signaling 6 Regulator of G protein signaling 6 (cDNA FLJ53896, highly similar to Regulator of G-protein signaling 6) Regulator of G-protein signaling 6 (Regulator of G-protein signalling 6, isoform CRA_i) Regulator of G-protein signaling 6 (RGS6) (S914) |
Synonyms | hCG_20660 |
Description | FUNCTION: Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. The RGS6/GNB5 dimer enhances GNAO1 GTPase activity . . |
Accessions | ENST00000553530.5 [P49758-4] ENST00000406236.8 [P49758-13] ENST00000355512.10 [P49758-16] A0A0A0MRA9 A0A087WTW9 ENST00000644463.1 ENST00000434263.6 ENST00000402788.6 A0A2R8Y8A2 ENST00000556437.5 [P49758-3] P49758 ENST00000404301.6 [P49758-15] ENST00000555571.5 [P49758-4] ENST00000553525.6 [P49758-3] B7Z7N5 B7Z2N1 Q2M3K2 ENST00000407322.8 [P49758-14] ENST00000554782.1 [P49758-12] ENST00000554474.5 [P49758-5] ENST00000343854.10 ENST00000622468.4 |