OPN5 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of OPN5 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of OPN5 at tissue level.

III. Associated gene sets

GO_0007601Biological processvisual perception
GO_0007604Biological processphototransduction, UV
GO_0043153Biological processentrainment of circadian clock by photoperiod
GO_0007186Biological processG protein-coupled receptor signaling pathway
GO_0009584Biological processdetection of visible light
GO_0007602Biological processphototransduction
GO_0071482Biological processcellular response to light stimulus
GO_0071492Biological processcellular response to UV-A
GO_1990384Biological processhyaloid vascular plexus regression
GO_0005886Cellular componentplasma membrane
GO_0005737Cellular componentcytoplasm
GO_0008020Molecular functionG protein-coupled photoreceptor activity
GO_0005502Molecular function11-cis retinal binding

IV. Literature review

[source]
Gene nameOPN5
Protein nameOpsin 5
Opsin-5 (G-protein coupled receptor 136) (G-protein coupled receptor PGR12) (Neuropsin) (Transmembrane protein 13)
SynonymsTMEM13
PGR12
hCG_1642475
GPR136
DescriptionFUNCTION: G-protein coupled receptor which selectively activates G(i) type G proteins via ultraviolet A (UVA) light-mediated activation in the retina (By similarity). Preferentially binds the chromophore 11-cis retinal and is a bistable protein that displays emission peaks at 380 nm (UVA light) and 470 nm (blue light) . Required for the light-response in the inner plexiform layer, and contributes to the regulation of the light-response in the nerve fiber layer, via phosphorylated DAT/SLC6A3 dopamine uptake (By similarity). Involved in local corneal and retinal circadian rhythm photoentrainment via modulation of the UVA light-induced phase-shift of the retina clock (By similarity). Acts as a circadian photoreceptor in the outer ear, via modulation of circadian clock-gene expression in response to violet light during the light-to-dark transition phase and night phase of the circadian cycle (By similarity). Required in the retina to negatively regulate hyaloid vessel regression during postnatal development via light-dependent OPN5-SLC32A1-DRD2-VEGFR2 signaling (By similarity). Involved in the light-dependent regulation of retina and vitreous compartment dopamine levels (By similarity). .

AccessionsENST00000393699.2
ENST00000371211.7
J3KPQ2
Q6U736
ENST00000489301.6
D6RDV4