Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| endothelial cell | 11 studies | 32% ± 13% | |
| capillary endothelial cell | 9 studies | 29% ± 12% | |
| endothelial cell of artery | 7 studies | 23% ± 9% | |
| glutamatergic neuron | 6 studies | 28% ± 16% | |
| endothelial cell of vascular tree | 6 studies | 23% ± 8% | |
| basal cell | 4 studies | 21% ± 3% | |
| secretory cell | 4 studies | 23% ± 11% | |
| glomerular endothelial cell | 3 studies | 41% ± 1% | |
| epithelial cell | 3 studies | 20% ± 5% | |
| GABAergic neuron | 3 studies | 31% ± 10% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| brain | 4 studies | 23% ± 11% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| kidney | 100% | 4919.56 | 89 / 89 | 98% | 118.75 | 882 / 901 |
| prostate | 100% | 6994.59 | 245 / 245 | 89% | 42.40 | 446 / 502 |
| thymus | 99% | 5014.43 | 647 / 653 | 88% | 56.54 | 533 / 605 |
| brain | 86% | 4870.61 | 2262 / 2642 | 99% | 68.10 | 699 / 705 |
| lung | 100% | 14710.65 | 576 / 578 | 77% | 55.17 | 891 / 1155 |
| breast | 100% | 18375.85 | 457 / 459 | 70% | 40.05 | 784 / 1118 |
| uterus | 97% | 3215.22 | 165 / 170 | 70% | 44.40 | 321 / 459 |
| bladder | 100% | 5245.43 | 21 / 21 | 42% | 22.81 | 211 / 504 |
| esophagus | 87% | 3256.73 | 1253 / 1445 | 54% | 27.03 | 99 / 183 |
| skin | 63% | 2416.00 | 1140 / 1809 | 76% | 26.27 | 357 / 472 |
| pancreas | 40% | 794.36 | 132 / 328 | 87% | 43.37 | 154 / 178 |
| intestine | 71% | 1808.65 | 688 / 966 | 48% | 14.33 | 254 / 527 |
| stomach | 60% | 1470.37 | 214 / 359 | 41% | 15.78 | 118 / 286 |
| blood vessel | 100% | 9065.74 | 1333 / 1335 | 0% | 0 | 0 / 0 |
| adipose | 100% | 9181.78 | 1200 / 1204 | 0% | 0 | 0 / 0 |
| liver | 38% | 659.68 | 85 / 226 | 57% | 19.62 | 233 / 406 |
| ovary | 34% | 932.28 | 62 / 180 | 57% | 18.77 | 244 / 430 |
| heart | 90% | 2702.54 | 778 / 861 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 82% | 66.36 | 37 / 45 |
| adrenal gland | 15% | 253.70 | 38 / 258 | 56% | 20.64 | 129 / 230 |
| muscle | 46% | 1001.04 | 370 / 803 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 45% | 6.90 | 13 / 29 |
| eye | 0% | 0 | 0 / 0 | 24% | 4.23 | 19 / 80 |
| spleen | 1% | 17.91 | 3 / 241 | 0% | 0 | 0 / 0 |
| peripheral blood | 1% | 8.10 | 5 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0002052 | Biological process | positive regulation of neuroblast proliferation |
| GO_1904141 | Biological process | positive regulation of microglial cell migration |
| GO_0006954 | Biological process | inflammatory response |
| GO_0010976 | Biological process | positive regulation of neuron projection development |
| GO_0050918 | Biological process | positive chemotaxis |
| GO_0032233 | Biological process | positive regulation of actin filament bundle assembly |
| GO_0060055 | Biological process | angiogenesis involved in wound healing |
| GO_0006935 | Biological process | chemotaxis |
| GO_0007267 | Biological process | cell-cell signaling |
| GO_0006955 | Biological process | immune response |
| GO_0070098 | Biological process | chemokine-mediated signaling pathway |
| GO_0043066 | Biological process | negative regulation of apoptotic process |
| GO_0097192 | Biological process | extrinsic apoptotic signaling pathway in absence of ligand |
| GO_2001234 | Biological process | negative regulation of apoptotic signaling pathway |
| GO_0051897 | Biological process | positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction |
| GO_0050767 | Biological process | regulation of neurogenesis |
| GO_0032720 | Biological process | negative regulation of tumor necrosis factor production |
| GO_0070374 | Biological process | positive regulation of ERK1 and ERK2 cascade |
| GO_0110091 | Biological process | negative regulation of hippocampal neuron apoptotic process |
| GO_0060326 | Biological process | cell chemotaxis |
| GO_0032914 | Biological process | positive regulation of transforming growth factor beta1 production |
| GO_0002931 | Biological process | response to ischemia |
| GO_0061518 | Biological process | microglial cell proliferation |
| GO_0043547 | Biological process | positive regulation of GTPase activity |
| GO_0032715 | Biological process | negative regulation of interleukin-6 production |
| GO_0030593 | Biological process | neutrophil chemotaxis |
| GO_0002523 | Biological process | leukocyte migration involved in inflammatory response |
| GO_0007155 | Biological process | cell adhesion |
| GO_1900450 | Biological process | negative regulation of glutamate receptor signaling pathway |
| GO_0032691 | Biological process | negative regulation of interleukin-1 beta production |
| GO_0007186 | Biological process | G protein-coupled receptor signaling pathway |
| GO_0098883 | Biological process | synapse pruning |
| GO_0030336 | Biological process | negative regulation of cell migration |
| GO_0050729 | Biological process | positive regulation of inflammatory response |
| GO_0033622 | Biological process | integrin activation |
| GO_0010812 | Biological process | negative regulation of cell-substrate adhesion |
| GO_2001223 | Biological process | negative regulation of neuron migration |
| GO_0001774 | Biological process | microglial cell activation |
| GO_0016322 | Biological process | neuron remodeling |
| GO_0035425 | Biological process | autocrine signaling |
| GO_0048661 | Biological process | positive regulation of smooth muscle cell proliferation |
| GO_0030595 | Biological process | leukocyte chemotaxis |
| GO_0051041 | Biological process | positive regulation of calcium-independent cell-cell adhesion |
| GO_1903721 | Biological process | positive regulation of I-kappaB phosphorylation |
| GO_0051281 | Biological process | positive regulation of release of sequestered calcium ion into cytosol |
| GO_0008284 | Biological process | positive regulation of cell population proliferation |
| GO_0031664 | Biological process | regulation of lipopolysaccharide-mediated signaling pathway |
| GO_0045944 | Biological process | positive regulation of transcription by RNA polymerase II |
| GO_0019221 | Biological process | cytokine-mediated signaling pathway |
| GO_0050902 | Biological process | leukocyte adhesive activation |
| GO_0001954 | Biological process | positive regulation of cell-matrix adhesion |
| GO_0032690 | Biological process | negative regulation of interleukin-1 alpha production |
| GO_0043410 | Biological process | positive regulation of MAPK cascade |
| GO_0070050 | Biological process | neuron cellular homeostasis |
| GO_0048167 | Biological process | regulation of synaptic plasticity |
| GO_0030335 | Biological process | positive regulation of cell migration |
| GO_0048247 | Biological process | lymphocyte chemotaxis |
| GO_0043123 | Biological process | positive regulation of canonical NF-kappaB signal transduction |
| GO_0048245 | Biological process | eosinophil chemotaxis |
| GO_0061844 | Biological process | antimicrobial humoral immune response mediated by antimicrobial peptide |
| GO_2001240 | Biological process | negative regulation of extrinsic apoptotic signaling pathway in absence of ligand |
| GO_0098609 | Biological process | cell-cell adhesion |
| GO_0006952 | Biological process | defense response |
| GO_0043025 | Cellular component | neuronal cell body |
| GO_0043005 | Cellular component | neuron projection |
| GO_0009986 | Cellular component | cell surface |
| GO_0005576 | Cellular component | extracellular region |
| GO_0005615 | Cellular component | extracellular space |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0016020 | Cellular component | membrane |
| GO_0048471 | Cellular component | perinuclear region of cytoplasm |
| GO_0042995 | Cellular component | cell projection |
| GO_0048020 | Molecular function | CCR chemokine receptor binding |
| GO_0031737 | Molecular function | CX3C chemokine receptor binding |
| GO_0005102 | Molecular function | signaling receptor binding |
| GO_0042056 | Molecular function | chemoattractant activity |
| GO_0008009 | Molecular function | chemokine activity |
| GO_0045237 | Molecular function | CXCR1 chemokine receptor binding |
| GO_0005515 | Molecular function | protein binding |
| GO_0005178 | Molecular function | integrin binding |
| Gene name | CX3CL1 |
| Protein name | Chemokine (C-X3-C motif) ligand 1 C-X3-C motif chemokine ligand 1 CX3CL1 protein Fractalkine (C-X3-C motif chemokine 1) (CX3C membrane-anchored chemokine) (Neurotactin) (Small-inducible cytokine D1) [Cleaved into: Processed fractalkine] |
| Synonyms | A-152E5.2 SCYD1 NTT FKN hCG_15105 |
| Description | FUNCTION: Chemokine that acts as a ligand for both CX3CR1 and integrins ITGAV:ITGB3 and ITGA4:ITGB1 . The CX3CR1-CX3CL1 signaling exerts distinct functions in different tissue compartments, such as immune response, inflammation, cell adhesion and chemotaxis . Regulates leukocyte adhesion and migration processes at the endothelium . Can activate integrins in both a CX3CR1-dependent and CX3CR1-independent manner . In the presence of CX3CR1, activates integrins by binding to the classical ligand-binding site (site 1) in integrins . In the absence of CX3CR1, binds to a second site (site 2) in integrins which is distinct from site 1 and enhances the binding of other integrin ligands to site 1 . .; FUNCTION: [Processed fractalkine]: The soluble form is chemotactic for T-cells and monocytes, but not for neutrophils. .; FUNCTION: [Fractalkine]: The membrane-bound form promotes adhesion of those leukocytes to endothelial cells. .; FUNCTION: (Microbial infection) Mediates the cytoadherence of erythrocytes infected with parasite P.falciparum (strain 3D7) with endothelial cells by interacting with P.falciparum CBP1 and CBP2 expressed at the surface of erythrocytes . The adhesion prevents the elimination of infected erythrocytes by the spleen (Probable). . |
| Accessions | ENST00000563383.1 H3BSR6 Q6I9S9 ENST00000006053.7 P78423 H3BV86 ENST00000564948.1 J3QRA1 ENST00000565912.1 A0N0N7 |
