Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| endothelial cell | 39 studies | 47% ± 22% | |
| capillary endothelial cell | 16 studies | 48% ± 20% | |
| vein endothelial cell | 15 studies | 58% ± 18% | |
| endothelial cell of vascular tree | 12 studies | 40% ± 17% | |
| endothelial cell of artery | 9 studies | 29% ± 10% | |
| endothelial cell of lymphatic vessel | 7 studies | 19% ± 3% | |
| glomerular endothelial cell | 4 studies | 65% ± 5% | |
| endothelial cell of sinusoid | 3 studies | 41% ± 14% |
Insufficient scRNA-seq data for expression of RAMP3 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| thymus | 100% | 4413.48 | 652 / 653 | 98% | 98.13 | 595 / 605 |
| prostate | 98% | 1782.44 | 239 / 245 | 97% | 40.60 | 486 / 502 |
| breast | 100% | 4073.74 | 459 / 459 | 90% | 80.90 | 1008 / 1118 |
| adrenal gland | 100% | 1725.86 | 257 / 258 | 89% | 74.87 | 205 / 230 |
| kidney | 100% | 4070.43 | 89 / 89 | 84% | 110.13 | 755 / 901 |
| intestine | 97% | 1377.23 | 933 / 966 | 84% | 22.91 | 441 / 527 |
| bladder | 100% | 1550.81 | 21 / 21 | 80% | 25.49 | 404 / 504 |
| lung | 100% | 8075.02 | 578 / 578 | 80% | 24.25 | 921 / 1155 |
| uterus | 99% | 1731.16 | 168 / 170 | 74% | 23.88 | 341 / 459 |
| stomach | 93% | 1146.48 | 335 / 359 | 80% | 21.57 | 228 / 286 |
| pancreas | 65% | 516.32 | 214 / 328 | 96% | 52.87 | 171 / 178 |
| esophagus | 94% | 1612.13 | 1356 / 1445 | 53% | 11.98 | 97 / 183 |
| skin | 63% | 781.17 | 1141 / 1809 | 83% | 34.03 | 391 / 472 |
| brain | 46% | 674.64 | 1212 / 2642 | 68% | 35.63 | 479 / 705 |
| liver | 38% | 315.03 | 85 / 226 | 72% | 24.13 | 292 / 406 |
| lymph node | 0% | 0 | 0 / 0 | 100% | 62.91 | 29 / 29 |
| ureter | 0% | 0 | 0 / 0 | 100% | 21.70 | 1 / 1 |
| adipose | 100% | 4414.94 | 1202 / 1204 | 0% | 0 | 0 / 0 |
| heart | 99% | 2386.61 | 856 / 861 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 87% | 28.47 | 39 / 45 |
| blood vessel | 78% | 1353.12 | 1047 / 1335 | 0% | 0 | 0 / 0 |
| spleen | 68% | 555.24 | 165 / 241 | 0% | 0 | 0 / 0 |
| muscle | 54% | 497.66 | 433 / 803 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 48% | 9.81 | 38 / 80 |
| ovary | 27% | 248.48 | 48 / 180 | 10% | 1.73 | 45 / 430 |
| peripheral blood | 1% | 3.89 | 5 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0001921 | Biological process | positive regulation of receptor recycling |
| GO_0031623 | Biological process | receptor internalization |
| GO_0072659 | Biological process | protein localization to plasma membrane |
| GO_0086103 | Biological process | G protein-coupled receptor signaling pathway involved in heart process |
| GO_0038041 | Biological process | cross-receptor inhibition within G protein-coupled receptor heterodimer |
| GO_0050850 | Biological process | positive regulation of calcium-mediated signaling |
| GO_1990410 | Biological process | adrenomedullin receptor signaling pathway |
| GO_0010628 | Biological process | positive regulation of gene expression |
| GO_0071392 | Biological process | cellular response to estradiol stimulus |
| GO_0006886 | Biological process | intracellular protein transport |
| GO_0032870 | Biological process | cellular response to hormone stimulus |
| GO_1904645 | Biological process | response to amyloid-beta |
| GO_1903078 | Biological process | positive regulation of protein localization to plasma membrane |
| GO_0097647 | Biological process | amylin receptor signaling pathway |
| GO_0007186 | Biological process | G protein-coupled receptor signaling pathway |
| GO_0010739 | Biological process | positive regulation of protein kinase A signaling |
| GO_0007189 | Biological process | adenylate cyclase-activating G protein-coupled receptor signaling pathway |
| GO_0051897 | Biological process | positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction |
| GO_0015031 | Biological process | protein transport |
| GO_0070374 | Biological process | positive regulation of ERK1 and ERK2 cascade |
| GO_0006816 | Biological process | calcium ion transport |
| GO_0150058 | Cellular component | amylin receptor complex 3 |
| GO_0043235 | Cellular component | receptor complex |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0005764 | Cellular component | lysosome |
| GO_0009986 | Cellular component | cell surface |
| GO_1903143 | Cellular component | adrenomedullin receptor complex |
| GO_0015026 | Molecular function | coreceptor activity |
| GO_0001540 | Molecular function | amyloid-beta binding |
| GO_0001605 | Molecular function | adrenomedullin receptor activity |
| GO_0097643 | Molecular function | amylin receptor activity |
| GO_0005515 | Molecular function | protein binding |
| Gene name | RAMP3 |
| Protein name | Receptor activity-modifying protein 3 (Calcitonin-receptor-like receptor activity-modifying protein 3) (CRLR activity-modifying protein 3) Receptor (G protein-coupled) activity modifying protein 3 Alternative protein RAMP3 Receptor activity-modifying protein 3 |
| Synonyms | hCG_17148 tcag7.792 |
| Description | FUNCTION: Plays a role in cardioprotection by reducing cardiac hypertrophy and perivascular fibrosis in a GPER1-dependent manner. Transports the calcitonin gene-related peptide type 1 receptor (CALCRL) and GPER1 to the plasma membrane. Acts as a receptor for adrenomedullin (AM) together with CALCRL. . |
| Accessions | M5AMS3 ENST00000242249.8 ENST00000481345.1 L8E7U1 A4D2L1 ENST00000496212.5 O60896 J3KR56 M5AP16 |
