GPR50 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of GPR50 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of GPR50 at tissue level.

III. Associated gene sets

GO_0007186Biological processG protein-coupled receptor signaling pathway
GO_0007267Biological processcell-cell signaling
GO_0005654Cellular componentnucleoplasm
GO_0005886Cellular componentplasma membrane
GO_0014069Cellular componentpostsynaptic density
GO_0008502Molecular functionmelatonin receptor activity
GO_0004930Molecular functionG protein-coupled receptor activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameGPR50
Protein nameMelatonin-related receptor (G protein-coupled receptor 50) (H9) [Cleaved into: C-terminal domain]
G protein-coupled receptor 50 variant b
G protein-coupled receptor 50 variant c
Synonyms
DescriptionFUNCTION: G protein-coupled receptor that plays a role in numerous physiological processes including regulation of energy metabolism, neurite outgrowth or cell migration . Promotes self-renewal and neuronal differentiation of neural progenitor cells through activation of the NOTCH and WNT/beta-catenin signaling pathways (By similarity). Modulates the KAT5-dependent glucocorticoid receptor signaling by modulating KAT5 subcellular compartmentalisation . Plays also a role in the activation TGFBR1 in the absence of TGFBR2 by interfering with FKBP1A binding to TGFBR1, leading to induction of both canonical and non-canonical SMAD signaling pathways resulting in inhibition of proliferation or promotion of migration . .; FUNCTION: [C-terminal domain]: Upon cleavage by CAPN1, functions as a scaffold in the nucleus for interacting partners such as GTF2I to promote FOS promoter activation. .

AccessionsENST00000218316.4
Q7Z582
Q13585
Q7Z581