GPR179 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of GPR179 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of GPR179 at tissue level.

III. Associated gene sets

GO_0007601Biological processvisual perception
GO_0007186Biological processG protein-coupled receptor signaling pathway
GO_0045211Cellular componentpostsynaptic membrane
GO_0030425Cellular componentdendrite
GO_0004930Molecular functionG protein-coupled receptor activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameGPR179
Protein nameProbable G-protein coupled receptor 179 (Probable G-protein coupled receptor 158-like 1) (GPR158-like)
G protein-coupled receptor 179
SynonymsGPR158L
GPR158L1
DescriptionFUNCTION: Orphan receptor involved in vision . Required for signal transduction through retinal depolarizing bipolar cells . Acts as an atypical G-protein coupled receptor that recruits and regulates the R7 group RGS-GNB5 complexes instead of activating G proteins: promotes the GTPase activator activity of R7 RGS proteins, increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form (By similarity). Associates with components of metabotropic signaling cascade in retina ON-bipolar neurons, such as TRPM1 and GRM6: may control the ability of the GRM6 cascade to gate TRPM1 (By similarity). .

AccessionsENST00000616987.5
Q6PRD1
A0A087X0K8
ENST00000610650.1