C5 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0032722Biological processpositive regulation of chemokine production
GO_0006957Biological processcomplement activation, alternative pathway
GO_0006954Biological processinflammatory response
GO_0006935Biological processchemotaxis
GO_0031640Biological processkilling of cells of another organism
GO_0007186Biological processG protein-coupled receptor signaling pathway
GO_0006958Biological processcomplement activation, classical pathway
GO_0010760Biological processnegative regulation of macrophage chemotaxis
GO_0010575Biological processpositive regulation of vascular endothelial growth factor production
GO_0060326Biological processcell chemotaxis
GO_0007166Biological processcell surface receptor signaling pathway
GO_0005615Cellular componentextracellular space
GO_0005576Cellular componentextracellular region
GO_0070062Cellular componentextracellular exosome
GO_0005579Cellular componentmembrane attack complex
GO_0008009Molecular functionchemokine activity
GO_0004866Molecular functionendopeptidase inhibitor activity
GO_0005102Molecular functionsignaling receptor binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameC5
Protein nameComplement C5
Complement C5 (C3 and PZP-like alpha-2-macroglobulin domain-containing protein 4) [Cleaved into: Complement C5 beta chain; Complement C5 alpha chain; C5a anaphylatoxin; Complement C5 alpha' chain]
Complement component 5
SynonymsCPAMD4
DescriptionFUNCTION: Activation of C5 by a C5 convertase initiates the spontaneous assembly of the late complement components, C5-C9, into the membrane attack complex. C5b has a transient binding site for C6. The C5b-C6 complex is the foundation upon which the lytic complex is assembled.; FUNCTION: [C5a anaphylatoxin]: Derived from proteolytic degradation of complement C5, C5a anaphylatoxin is a mediator of local inflammatory process. Binding to the receptor C5AR1 induces a variety of responses including intracellular calcium release, contraction of smooth muscle, increased vascular permeability, and histamine release from mast cells and basophilic leukocytes . C5a is also a potent chemokine which stimulates the locomotion of polymorphonuclear leukocytes and directs their migration toward sites of inflammation. .

AccessionsU6BZC6
P01031
ENST00000697922.1
ENST00000466280.2
A0A8V8TN26
A0A8Q3SIH6
A0A8V8TMU5
ENST00000223642.3
A0A8Q3SID6
ENST00000696281.1
ENST00000696279.1