APLP2 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
macrophage	47 studies	52% ± 18%	Explore
endothelial cell	45 studies	41% ± 17%	Explore
fibroblast	39 studies	44% ± 18%	Explore
pericyte	32 studies	40% ± 16%	Explore
classical monocyte	29 studies	69% ± 17%	Explore
smooth muscle cell	27 studies	41% ± 13%	Explore
endothelial cell of lymphatic vessel	25 studies	49% ± 18%	Explore
conventional dendritic cell	25 studies	38% ± 15%	Explore
non-classical monocyte	24 studies	53% ± 12%	Explore
monocyte	23 studies	53% ± 19%	Explore
epithelial cell	21 studies	50% ± 20%	Explore
basal cell	20 studies	49% ± 19%	Explore
myeloid cell	18 studies	49% ± 22%	Explore
ciliated cell	17 studies	50% ± 15%	Explore
naive B cell	17 studies	26% ± 9%	Explore
connective tissue cell	17 studies	38% ± 10%	Explore
dendritic cell	15 studies	40% ± 14%	Explore
myofibroblast cell	15 studies	42% ± 12%	Explore
natural killer cell	14 studies	21% ± 4%	Explore
capillary endothelial cell	14 studies	34% ± 12%	Explore
microglial cell	14 studies	35% ± 12%	Explore
astrocyte	13 studies	35% ± 13%	Explore
type I pneumocyte	12 studies	70% ± 24%	Explore
type II pneumocyte	12 studies	59% ± 26%	Explore
glutamatergic neuron	12 studies	43% ± 20%	Explore
B cell	12 studies	22% ± 6%	Explore
endothelial cell of artery	12 studies	44% ± 17%	Explore
mesothelial cell	12 studies	41% ± 15%	Explore
vein endothelial cell	12 studies	38% ± 14%	Explore
endothelial cell of vascular tree	12 studies	36% ± 9%	Explore
neutrophil	11 studies	42% ± 19%	Explore
secretory cell	11 studies	49% ± 19%	Explore
oligodendrocyte precursor cell	11 studies	34% ± 15%	Explore
club cell	10 studies	53% ± 18%	Explore
GABAergic neuron	10 studies	46% ± 20%	Explore
CD16-positive, CD56-dim natural killer cell, human	10 studies	21% ± 4%	Explore
neuron	9 studies	41% ± 14%	Explore
alveolar macrophage	8 studies	64% ± 17%	Explore
leukocyte	8 studies	29% ± 6%	Explore
goblet cell	8 studies	36% ± 14%	Explore
amacrine cell	8 studies	48% ± 20%	Explore
retinal cone cell	8 studies	59% ± 21%	Explore
retinal rod cell	8 studies	49% ± 12%	Explore
interneuron	8 studies	52% ± 21%	Explore
T cell	7 studies	30% ± 13%	Explore
mast cell	7 studies	20% ± 3%	Explore
respiratory goblet cell	7 studies	52% ± 18%	Explore
mononuclear phagocyte	7 studies	42% ± 14%	Explore
epithelial cell of proximal tubule	7 studies	30% ± 11%	Explore
progenitor cell	7 studies	38% ± 10%	Explore
abnormal cell	7 studies	41% ± 9%	Explore
enterocyte	7 studies	35% ± 11%	Explore
retinal ganglion cell	7 studies	71% ± 29%	Explore
ionocyte	6 studies	85% ± 12%	Explore
kidney loop of Henle epithelial cell	6 studies	50% ± 26%	Explore
renal alpha-intercalated cell	6 studies	58% ± 16%	Explore
hepatocyte	6 studies	46% ± 23%	Explore
oligodendrocyte	6 studies	25% ± 8%	Explore
hematopoietic precursor cell	5 studies	43% ± 17%	Explore
kidney distal convoluted tubule epithelial cell	5 studies	65% ± 20%	Explore
transit amplifying cell	5 studies	28% ± 14%	Explore
retinal bipolar neuron	5 studies	70% ± 15%	Explore
glial cell	5 studies	31% ± 14%	Explore
ON-bipolar cell	5 studies	69% ± 23%	Explore
hematopoietic stem cell	5 studies	41% ± 16%	Explore
brush cell	5 studies	27% ± 14%	Explore
retina horizontal cell	5 studies	48% ± 18%	Explore
retinal pigment epithelial cell	5 studies	60% ± 21%	Explore
intermediate monocyte	5 studies	62% ± 15%	Explore
deuterosomal cell	4 studies	37% ± 11%	Explore
squamous epithelial cell	4 studies	50% ± 22%	Explore
pancreatic A cell	4 studies	46% ± 15%	Explore
mature NK T cell	4 studies	20% ± 3%	Explore
podocyte	4 studies	78% ± 5%	Explore
enteroendocrine cell	4 studies	37% ± 10%	Explore
granule cell	4 studies	44% ± 14%	Explore
OFF-bipolar cell	4 studies	77% ± 13%	Explore
adventitial cell	4 studies	50% ± 13%	Explore
mucus secreting cell	4 studies	28% ± 4%	Explore
Mueller cell	4 studies	50% ± 7%	Explore
erythroblast	4 studies	42% ± 17%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	66% ± 5%	Explore
luminal cell of prostate epithelium	4 studies	37% ± 9%	Explore
duct epithelial cell	3 studies	58% ± 10%	Explore
hillock cell	3 studies	34% ± 13%	Explore
plasmablast	3 studies	30% ± 3%	Explore
platelet	3 studies	26% ± 9%	Explore
pancreatic D cell	3 studies	58% ± 25%	Explore
type B pancreatic cell	3 studies	59% ± 22%	Explore
monocyte-derived dendritic cell	3 studies	40% ± 23%	Explore
glomerular endothelial cell	3 studies	38% ± 9%	Explore
neural crest cell	3 studies	23% ± 3%	Explore
GABAergic interneuron	3 studies	34% ± 7%	Explore
GABAergic amacrine cell	3 studies	55% ± 13%	Explore
glycinergic amacrine cell	3 studies	36% ± 14%	Explore
renal principal cell	3 studies	73% ± 1%	Explore
placental villous trophoblast	3 studies	92% ± 4%	Explore
common myeloid progenitor	3 studies	46% ± 12%	Explore
lymphocyte	3 studies	43% ± 14%	Explore
precursor B cell	3 studies	28% ± 2%	Explore
innate lymphoid cell	3 studies	26% ± 8%	Explore
neuroendocrine cell	3 studies	47% ± 22%	Explore
immature B cell	3 studies	23% ± 5%	Explore
serous secreting cell	3 studies	33% ± 5%	Explore
tissue-resident macrophage	3 studies	58% ± 11%	Explore
rod bipolar cell	3 studies	94% ± 1%	Explore
inflammatory macrophage	3 studies	47% ± 16%	Explore
myoepithelial cell	3 studies	57% ± 17%	Explore
muscle cell	3 studies	37% ± 16%	Explore
pancreatic ductal cell	3 studies	87% ± 10%	Explore
neural progenitor cell	3 studies	32% ± 14%	Explore
megakaryocyte-erythroid progenitor cell	3 studies	48% ± 21%	Explore
melanocyte	3 studies	30% ± 4%	Explore
erythrocyte	3 studies	42% ± 19%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	20 studies	44% ± 17%	Explore
brain	19 studies	36% ± 16%	Explore
peripheral blood	18 studies	28% ± 7%	Explore
eye	10 studies	53% ± 11%	Explore
intestine	9 studies	32% ± 12%	Explore
kidney	9 studies	33% ± 13%	Explore
liver	6 studies	36% ± 18%	Explore
adipose	5 studies	30% ± 8%	Explore
pancreas	4 studies	49% ± 21%	Explore
placenta	4 studies	57% ± 24%	Explore
bone marrow	4 studies	31% ± 10%	Explore
uterus	4 studies	53% ± 19%	Explore
breast	4 studies	35% ± 7%	Explore
prostate	4 studies	23% ± 6%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	24356.19	1445 / 1445	100%	234.25	183 / 183
prostate	100%	25263.90	245 / 245	100%	558.51	502 / 502
kidney	100%	33984.11	89 / 89	100%	429.84	897 / 901
lung	100%	45765.29	578 / 578	99%	386.82	1147 / 1155
brain	99%	26699.47	2624 / 2642	100%	296.01	704 / 705
thymus	100%	53625.52	653 / 653	99%	1361.41	598 / 605
intestine	100%	26073.04	966 / 966	99%	220.41	520 / 527
breast	100%	30687.59	459 / 459	98%	312.71	1100 / 1118
bladder	100%	28401.62	21 / 21	98%	281.81	495 / 504
ovary	100%	25213.24	180 / 180	98%	230.17	420 / 430
liver	100%	17977.67	226 / 226	97%	225.96	393 / 406
stomach	100%	18275.21	358 / 359	97%	206.30	276 / 286
adrenal gland	100%	19709.34	257 / 258	96%	186.91	220 / 230
uterus	100%	27037.60	170 / 170	93%	207.36	426 / 459
skin	100%	24696.51	1807 / 1809	90%	191.02	424 / 472
pancreas	87%	8562.42	285 / 328	98%	326.19	175 / 178
adipose	100%	32430.55	1204 / 1204	0%	0	0 / 0
blood vessel	100%	48983.80	1335 / 1335	0%	0	0 / 0
ureter	0%	0	0 / 0	100%	146.21	1 / 1
spleen	100%	14005.87	240 / 241	0%	0	0 / 0
heart	96%	21511.86	829 / 861	0%	0	0 / 0
tonsil	0%	0	0 / 0	93%	136.39	42 / 45
eye	0%	0	0 / 0	93%	199.39	74 / 80
peripheral blood	80%	20607.53	747 / 929	0%	0	0 / 0
muscle	71%	5389.70	568 / 803	0%	0	0 / 0
lymph node	0%	0	0 / 0	66%	76.21	19 / 29
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0007409	Biological process	axonogenesis
GO_0007186	Biological process	G protein-coupled receptor signaling pathway
GO_0007417	Biological process	central nervous system development
GO_0031092	Cellular component	platelet alpha granule membrane
GO_0005788	Cellular component	endoplasmic reticulum lumen
GO_0070062	Cellular component	extracellular exosome
GO_0005886	Cellular component	plasma membrane
GO_0016020	Cellular component	membrane
GO_0005634	Cellular component	nucleus
GO_0003677	Molecular function	DNA binding
GO_0008201	Molecular function	heparin binding
GO_0004867	Molecular function	serine-type endopeptidase inhibitor activity
GO_0042802	Molecular function	identical protein binding
GO_0046914	Molecular function	transition metal ion binding
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	APLP2
Protein name	Amyloid beta precursor like protein 2 (Amyloid-like protein 2) Amyloid beta precursor like protein 2 (APPH) (Amyloid beta (A4) precursor-like protein 2) (Amyloid protein homolog) (Amyloid-like protein 2) (APLP-2) (CDEI box-binding protein) (CDEBP) (Sperm membrane protein YWK-II) Amyloid beta precursor like protein 2 Alternative protein APLP2
Synonyms	APPL2
Description	FUNCTION: May play a role in the regulation of hemostasis. The soluble form may have inhibitory properties towards coagulation factors. May interact with cellular G-protein signaling pathways. May bind to the DNA 5'-GTCACATG-3'(CDEI box). Inhibits trypsin, chymotrypsin, plasmin, factor XIA and plasma and glandular kallikrein. Modulates the Cu/Zn nitric oxide-catalyzed autodegradation of GPC1 heparan sulfate side chains in fibroblasts (By similarity). .
Accessions	ENST00000650012.1 [Q06481-1] E9PSC7 ENST00000278756.7 [Q06481-6] ENST00000533713.5 E9PQS3 ENST00000338167.10 [Q06481-3] Q9UED0 ENST00000528499.5 [Q06481-4] ENST00000345598.9 [Q06481-5] ENST00000533616.5 ENST00000263574.9 [Q06481-1] ENST00000533195.5 Q06481 E9PPD0 L8E7K0 ENST00000530132.5

APLP2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review