SUCNR1 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of SUCNR1 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of SUCNR1 at tissue level.

III. Associated gene sets

GO_0097009Biological processenergy homeostasis
GO_0002281Biological processmacrophage activation involved in immune response
GO_0051592Biological processresponse to calcium ion
GO_0050729Biological processpositive regulation of inflammatory response
GO_0007186Biological processG protein-coupled receptor signaling pathway
GO_0060177Biological processregulation of angiotensin metabolic process
GO_0002001Biological processrenin secretion into blood stream
GO_0042593Biological processglucose homeostasis
GO_0050921Biological processpositive regulation of chemotaxis
GO_0070062Cellular componentextracellular exosome
GO_0005886Cellular componentplasma membrane
GO_0038023Molecular functionsignaling receptor activity
GO_0004930Molecular functionG protein-coupled receptor activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameSUCNR1
Protein nameSuccinate receptor 1 (G-protein coupled receptor 91) (P2Y purinoceptor 1-like)
SynonymsGPR91
DescriptionFUNCTION: G protein-coupled receptor for succinate able to mediate signaling through Gq/GNAQ or Gi/GNAI second messengers depending on the cell type and the processes regulated (By similarity) . Succinate-SUCNR1 signaling serves as a link between metabolic stress, inflammation and energy homeostasis . In macrophages, plays a range of immune-regulatory roles. During inflammation, succinate-SUCNR1 signaling may act as an anti-inflammatory mediator or boost inflammation depending on the inflammatory status of cells (By similarity). Hyperpolarizes M2 macrophages versus M1 phenotype through Gq signaling by regulating the transcription of genes involoved in immune function . In activated M1 macrophages, plays a pro-inflammatory role in response to LPS (By similarity). Expressed in dendritic cells, where it is involved in the sensing of immunological danger and enhances immunity. Mediates succinate triggered intracelleular calcium mobilization, induces migratory responses and acts in synergy with Toll-like receptor ligands for the production of proinflammatory cytokines as well as an enhancement of antigen-specific activation of helper T cells . In the small intestine, mediates the activation of tuft cells by dietary succinate and triggers type 2 immunity (By similarity). In adipocytes, plays an important role in the control of energy metabolism. In response to succinate, controls leptin expression in an AMPK-JNK-CEBPA-dependent as well as circadian clock-regulated manner (By similarity). In muscle tissue, is expressed in non-muscle cells and coordinates muscle remodeling in response to the succinate produced during exercise training in a paracrine manner (By similarity). In retina, acts as a mediator of vessel growth during retinal development. In response to succinate, regulates the production of angiogenic factors, including VEGF, by retinal ganglion neurons (By similarity). .

AccessionsQ9BXA5
ENST00000362032.6