TAS2R43 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of TAS2R43 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of TAS2R43 at tissue level.

III. Associated gene sets

GO_0007186Biological processG protein-coupled receptor signaling pathway
GO_0001580Biological processdetection of chemical stimulus involved in sensory perception of bitter taste
GO_0060170Cellular componentciliary membrane
GO_0031514Cellular componentmotile cilium
GO_0005886Cellular componentplasma membrane
GO_0016020Cellular componentmembrane
GO_0004930Molecular functionG protein-coupled receptor activity
GO_0008527Molecular functiontaste receptor activity
GO_0033038Molecular functionbitter taste receptor activity

IV. Literature review

[source]
Gene nameTAS2R43
Protein nameTaste receptor type 2
Taste receptor type 2 member 43 (T2R43) (Taste receptor type 2 member 52) (T2R52)
Synonyms
DescriptionFUNCTION: Gustducin-coupled receptor immplicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5. Activated by the sulfonyl amide sweeteners saccharin and acesulfame K. In airway epithelial cells, binding of bitter compounds increases the intracellular calcium ion concentration and stimulates ciliary beat frequency. May act as chemosensory receptors in airway epithelial cells to detect and eliminate potential noxious agents from the airways (By similarity). .

AccessionsP59537
ENST00000571879.1
ENST00000531678.1
ENST00000632197.1
A0A0J9YXD8