APOC3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0045833Biological processnegative regulation of lipid metabolic process
GO_0010903Biological processnegative regulation of very-low-density lipoprotein particle remodeling
GO_0070328Biological processtriglyceride homeostasis
GO_0060621Biological processnegative regulation of cholesterol import
GO_0034382Biological processchylomicron remnant clearance
GO_0010897Biological processnegative regulation of triglyceride catabolic process
GO_0010916Biological processnegative regulation of very-low-density lipoprotein particle clearance
GO_0010989Biological processnegative regulation of low-density lipoprotein particle clearance
GO_0043691Biological processreverse cholesterol transport
GO_0032489Biological processregulation of Cdc42 protein signal transduction
GO_0034379Biological processvery-low-density lipoprotein particle assembly
GO_0010987Biological processnegative regulation of high-density lipoprotein particle clearance
GO_0033700Biological processphospholipid efflux
GO_0034375Biological processhigh-density lipoprotein particle remodeling
GO_0042157Biological processlipoprotein metabolic process
GO_0019433Biological processtriglyceride catabolic process
GO_0007186Biological processG protein-coupled receptor signaling pathway
GO_0006641Biological processtriglyceride metabolic process
GO_0045717Biological processnegative regulation of fatty acid biosynthetic process
GO_0050995Biological processnegative regulation of lipid catabolic process
GO_0048261Biological processnegative regulation of receptor-mediated endocytosis
GO_0033344Biological processcholesterol efflux
GO_0051005Biological processnegative regulation of lipoprotein lipase activity
GO_0042632Biological processcholesterol homeostasis
GO_0042627Cellular componentchylomicron
GO_0005615Cellular componentextracellular space
GO_0005576Cellular componentextracellular region
GO_0034366Cellular componentspherical high-density lipoprotein particle
GO_0005769Cellular componentearly endosome
GO_0070062Cellular componentextracellular exosome
GO_0062023Cellular componentcollagen-containing extracellular matrix
GO_0034361Cellular componentvery-low-density lipoprotein particle
GO_0034363Cellular componentintermediate-density lipoprotein particle
GO_0070653Molecular functionhigh-density lipoprotein particle receptor binding
GO_0015485Molecular functioncholesterol binding
GO_0005543Molecular functionphospholipid binding
GO_0055102Molecular functionlipase inhibitor activity
GO_0030234Molecular functionenzyme regulator activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameAPOC3
Protein nameApolipoprotein C-III (Apo-CIII) (ApoC-III) (Apolipoprotein C3)
Apolipoprotein C-III (Apolipoprotein C3)
SynonymshCG_41334
DescriptionFUNCTION: Component of triglyceride-rich very low density lipoproteins (VLDL) and high density lipoproteins (HDL) in plasma . Plays a multifaceted role in triglyceride homeostasis . Intracellularly, promotes hepatic very low density lipoprotein 1 (VLDL1) assembly and secretion; extracellularly, attenuates hydrolysis and clearance of triglyceride-rich lipoproteins (TRLs) . Impairs the lipolysis of TRLs by inhibiting lipoprotein lipase and the hepatic uptake of TRLs by remnant receptors . Formed of several curved helices connected via semiflexible hinges, so that it can wrap tightly around the curved micelle surface and easily adapt to the different diameters of its natural binding partners . .

AccessionsP02656
A3KPE2
ENST00000630701.1
C9J2Q0
ENST00000375345.3
ENST00000433777.5
ENST00000227667.8
B0YIW2