DEFB4A | OmnibusX

sc-RNAseq data

Insufficient scRNA-seq data for expression of DEFB4A at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	23%	273.65	329 / 1445	53%	27.60	97 / 183
tonsil	0%	0	0 / 0	69%	62.97	31 / 45
lung	21%	44.05	124 / 578	26%	6.27	297 / 1155
stomach	13%	35.65	46 / 359	16%	5.63	47 / 286
uterus	0%	0	0 / 170	27%	8.45	126 / 459
ovary	0%	0	0 / 180	20%	2.53	84 / 430
skin	5%	10.47	96 / 1809	10%	6.59	45 / 472
intestine	1%	0.67	10 / 966	12%	3.64	65 / 527
bladder	0%	0	0 / 21	7%	2.03	37 / 504
thymus	0%	0	0 / 653	2%	0.88	10 / 605
kidney	1%	0.63	1 / 89	0%	0.03	4 / 901
breast	0%	0.16	2 / 459	1%	0.29	11 / 1118
peripheral blood	1%	1.13	6 / 929	0%	0	0 / 0
pancreas	0%	0	0 / 328	1%	0.01	1 / 178
liver	0%	0.14	1 / 226	0%	0	0 / 406
adrenal gland	0%	0.10	1 / 258	0%	0	0 / 230
blood vessel	0%	0.36	3 / 1335	0%	0	0 / 0
prostate	0%	0	0 / 245	0%	0.00	1 / 502
brain	0%	0.03	1 / 2642	0%	0.00	1 / 705
adipose	0%	0.03	1 / 1204	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
eye	0%	0	0 / 0	0%	0	0 / 80
gingiva	0%	0	0 / 0	0%	0	0 / 0
heart	0%	0	0 / 861	0%	0	0 / 0
lymph node	0%	0	0 / 0	0%	0	0 / 29
muscle	0%	0	0 / 803	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
spleen	0%	0	0 / 241	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

GO_0050832	Biological process	defense response to fungus
GO_0061760	Biological process	antifungal innate immune response
GO_0050918	Biological process	positive chemotaxis
GO_0050829	Biological process	defense response to Gram-negative bacterium
GO_0006935	Biological process	chemotaxis
GO_0006955	Biological process	immune response
GO_0031640	Biological process	killing of cells of another organism
GO_0007186	Biological process	G protein-coupled receptor signaling pathway
GO_0050830	Biological process	defense response to Gram-positive bacterium
GO_0042742	Biological process	defense response to bacterium
GO_0061844	Biological process	antimicrobial humoral immune response mediated by antimicrobial peptide
GO_0060326	Biological process	cell chemotaxis
GO_0005615	Cellular component	extracellular space
GO_0005576	Cellular component	extracellular region
GO_0005796	Cellular component	Golgi lumen
GO_0005546	Molecular function	phosphatidylinositol-4,5-bisphosphate binding
GO_0042056	Molecular function	chemoattractant activity
GO_0005515	Molecular function	protein binding
GO_0031731	Molecular function	CCR6 chemokine receptor binding

Gene name	DEFB4A
Protein name	Defensin beta 4A (Beta-defensin 2) (BD-2) (hBD-2) (Defensin, beta 2) (Skin-antimicrobial peptide 1) (SAP1)
Synonyms	DEFB102 DEFB4B DEFB2 DEFB4;
Description	FUNCTION: Exhibits antimicrobial activity against Gram-negative bacteria and Gram-positive bacteria, with highest activity against Gram-negative bacteria . Antimicrobial activity against P.aruginosa seems to be salt-sensitive and is reduced with high salt concentrations greater than 25 mM . Also exhibits antimicrobial activity against the yeast C.albicans . Permeabilizes C.albicans cell membranes via targeting plasma membrane lipid phosphatidylinositol 4,5-bisphosphate (PIP2), thereby leading to cell fragmentation and cell death . Acts as a ligand for C-C chemokine receptor CCR6 . Binds to CCR6 and induces chemotactic activity of CCR6-expressing cells, such as immature dendritic cells and memory T cells . .
Accessions	O15263 ENST00000318157.3 ENST00000302247.3 ENST00000642856.2 ENST00000617136.2 ENST00000644124.2

DEFB4A report