HCAR2 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of HCAR2 at tissue level.

III. Associated gene sets

GO_0007186Biological processG protein-coupled receptor signaling pathway
GO_0033031Biological processpositive regulation of neutrophil apoptotic process
GO_0070165Biological processpositive regulation of adiponectin secretion
GO_0001781Biological processneutrophil apoptotic process
GO_0050995Biological processnegative regulation of lipid catabolic process
GO_0030054Cellular componentcell junction
GO_0005886Cellular componentplasma membrane
GO_0070553Molecular functionnicotinic acid receptor activity

IV. Literature review

[source]
Gene nameHCAR2
Protein nameHydroxycarboxylic acid receptor 2
Hydroxycarboxylic acid receptor 2 (G-protein coupled receptor 109A) (G-protein coupled receptor HM74A) (Niacin receptor 1) (Nicotinic acid receptor)
SynonymsNIACR1
HM74A
HCA2
GPR109A
DescriptionFUNCTION: Acts as a high affinity receptor for both nicotinic acid (also known as niacin) and (D)-beta-hydroxybutyrate and mediates increased adiponectin secretion and decreased lipolysis through G(i)-protein-mediated inhibition of adenylyl cyclase. This pharmacological effect requires nicotinic acid doses that are much higher than those provided by a normal diet. Mediates nicotinic acid-induced apoptosis in mature neutrophils. Receptor activation by nicotinic acid results in reduced cAMP levels which may affect activity of cAMP-dependent protein kinase A and phosphorylation of target proteins, leading to neutrophil apoptosis. The rank order of potency for the displacement of nicotinic acid binding is 5-methyl pyrazole-3-carboxylic acid = pyridine-3-acetic acid > acifran > 5-methyl nicotinic acid = acipimox >> nicotinuric acid = nicotinamide. .

AccessionsENST00000328880.6
A0A4Y1JWQ0
Q8TDS4