RAMP2 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	40 studies	62% ± 29%	Explore
endothelial cell of lymphatic vessel	23 studies	70% ± 22%	Explore
capillary endothelial cell	17 studies	68% ± 25%	Explore
endothelial cell of artery	15 studies	70% ± 25%	Explore
fibroblast	14 studies	35% ± 20%	Explore
vein endothelial cell	13 studies	69% ± 23%	Explore
endothelial cell of vascular tree	12 studies	56% ± 25%	Explore
pericyte	11 studies	35% ± 27%	Explore
myofibroblast cell	7 studies	23% ± 4%	Explore
connective tissue cell	7 studies	35% ± 16%	Explore
mesothelial cell	5 studies	41% ± 20%	Explore
glomerular endothelial cell	4 studies	90% ± 6%	Explore
smooth muscle cell	3 studies	18% ± 3%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
intestine	4 studies	23% ± 10%	Explore
lung	3 studies	33% ± 5%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
thymus	99%	2114.41	646 / 653	98%	73.43	595 / 605
breast	100%	4578.73	459 / 459	97%	73.67	1087 / 1118
prostate	98%	1208.42	240 / 245	98%	37.39	490 / 502
lung	100%	4490.89	578 / 578	93%	36.75	1074 / 1155
ovary	93%	837.14	168 / 180	95%	40.16	410 / 430
uterus	99%	1865.68	169 / 170	88%	41.50	406 / 459
bladder	95%	1306.24	20 / 21	91%	31.36	461 / 504
kidney	98%	1385.92	87 / 89	88%	86.96	795 / 901
esophagus	86%	1129.19	1241 / 1445	95%	40.24	173 / 183
adrenal gland	87%	693.84	225 / 258	93%	59.61	213 / 230
intestine	91%	988.24	878 / 966	88%	31.15	465 / 527
brain	72%	533.72	1909 / 2642	100%	61.13	705 / 705
stomach	78%	692.74	281 / 359	94%	50.07	268 / 286
skin	67%	936.30	1208 / 1809	92%	49.81	433 / 472
pancreas	17%	93.15	57 / 328	98%	48.88	174 / 178
liver	12%	70.47	27 / 226	89%	29.76	362 / 406
adipose	100%	4772.42	1204 / 1204	0%	0	0 / 0
ureter	0%	0	0 / 0	100%	16.93	1 / 1
spleen	98%	1084.34	237 / 241	0%	0	0 / 0
heart	98%	1511.48	846 / 861	0%	0	0 / 0
tonsil	0%	0	0 / 0	91%	31.55	41 / 45
lymph node	0%	0	0 / 0	86%	23.89	25 / 29
eye	0%	0	0 / 0	81%	23.29	65 / 80
blood vessel	79%	949.00	1060 / 1335	0%	0	0 / 0
muscle	72%	478.40	580 / 803	0%	0	0 / 0
peripheral blood	1%	4.14	5 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0001525	Biological process	angiogenesis
GO_2000352	Biological process	negative regulation of endothelial cell apoptotic process
GO_0031623	Biological process	receptor internalization
GO_0072659	Biological process	protein localization to plasma membrane
GO_0034333	Biological process	adherens junction assembly
GO_1990410	Biological process	adrenomedullin receptor signaling pathway
GO_0007507	Biological process	heart development
GO_0045766	Biological process	positive regulation of angiogenesis
GO_0043116	Biological process	negative regulation of vascular permeability
GO_0008217	Biological process	regulation of blood pressure
GO_0010628	Biological process	positive regulation of gene expression
GO_0001570	Biological process	vasculogenesis
GO_0006886	Biological process	intracellular protein transport
GO_0032870	Biological process	cellular response to hormone stimulus
GO_0097084	Biological process	vascular associated smooth muscle cell development
GO_0002040	Biological process	sprouting angiogenesis
GO_0007186	Biological process	G protein-coupled receptor signaling pathway
GO_0008277	Biological process	regulation of G protein-coupled receptor signaling pathway
GO_0070830	Biological process	bicellular tight junction assembly
GO_0007189	Biological process	adenylate cyclase-activating G protein-coupled receptor signaling pathway
GO_2001214	Biological process	positive regulation of vasculogenesis
GO_0015031	Biological process	protein transport
GO_0035924	Biological process	cellular response to vascular endothelial growth factor stimulus
GO_0006816	Biological process	calcium ion transport
GO_0070831	Biological process	basement membrane assembly
GO_0043235	Cellular component	receptor complex
GO_0005886	Cellular component	plasma membrane
GO_0005764	Cellular component	lysosome
GO_0009986	Cellular component	cell surface
GO_0005737	Cellular component	cytoplasm
GO_1903143	Cellular component	adrenomedullin receptor complex
GO_0005905	Cellular component	clathrin-coated pit
GO_0015026	Molecular function	coreceptor activity
GO_1990409	Molecular function	adrenomedullin binding
GO_0001605	Molecular function	adrenomedullin receptor activity
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	RAMP2
Protein name	Receptor activity modifying protein 2 Receptor activity-modifying protein 2 (Calcitonin-receptor-like receptor activity-modifying protein 2) (CRLR activity-modifying protein 2)
Synonyms
Description	FUNCTION: Transports the calcitonin gene-related peptide type 1 receptor (CALCRL) to the plasma membrane. Acts as a receptor for adrenomedullin (AM) together with CALCRL. .
Accessions	K7EKQ3 ENST00000253796.10 [O60895-1] K7ENJ8 ENST00000588928.1 K7EPN3 ENST00000589683.5 O60895 ENST00000588576.1 ENST00000587142.5 [O60895-2]

RAMP2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review