NPFFR2 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of NPFFR2 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of NPFFR2 at tissue level.

III. Associated gene sets

GO_0007186Biological processG protein-coupled receptor signaling pathway
GO_0007218Biological processneuropeptide signaling pathway
GO_0032870Biological processcellular response to hormone stimulus
GO_0043408Biological processregulation of MAPK cascade
GO_0009582Biological processdetection of abiotic stimulus
GO_0015629Cellular componentactin cytoskeleton
GO_0005886Cellular componentplasma membrane
GO_0042277Molecular functionpeptide binding
GO_0031628Molecular functionopioid receptor binding
GO_0004930Molecular functionG protein-coupled receptor activity
GO_0008188Molecular functionneuropeptide receptor activity

IV. Literature review

[source]
Gene nameNPFFR2
Protein nameNeuropeptide FF receptor 2
Neuropeptide FF receptor 2 (G-protein coupled receptor 74) (G-protein coupled receptor HLWAR77) (Neuropeptide G-protein coupled receptor)
Neuropeptide FF receptor 2 (cDNA FLJ75415, highly similar to Homo sapiens G protein-coupled receptor 74 (GPR74), transcript variant 2, mRNA)
SynonymsNPGPR
hCG_15026
GPR74
NPFF2
DescriptionFUNCTION: Receptor for NPAF (A-18-F-amide) and NPFF (F-8-F-amide) neuropeptides, also known as morphine-modulating peptides. Can also be activated by a variety of naturally occurring or synthetic FMRF-amide like ligands. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.

FUNCTION: Receptor for NPAF (A-18-F-amide) and NPFF (F-8-F-amide) neuropeptides, also known as morphine-modulating peptides. Can also be activated by a variety of naturally occurring or synthetic FMRF-amide like ligands. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. .

FUNCTION: Receptor for NPAF (A-18-F-amide) and NPFF (F-8-F-amide) neuropeptides, also known as morphine-modulating peptides. Can also be activated by a variety of naturally occurring or synthetic FMRF-amide like ligands. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. .

AccessionsENST00000344413.6
A0PJM9
Q9Y5X5
ENST00000308744.12 [Q9Y5X5-2]
A0A804CC06
ENST00000395999.5 [Q9Y5X5-3]
ENST00000358749.3 [Q9Y5X5-2]