GPBAR1 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of GPBAR1 at tissue level.

III. Associated gene sets

GO_0038184Biological processadenylate cyclase-activating G protein-coupled bile acid receptor signaling pathway
GO_1903413Biological processcellular response to bile acid
GO_0007186Biological processG protein-coupled receptor signaling pathway
GO_2000810Biological processregulation of bicellular tight junction assembly
GO_0070374Biological processpositive regulation of ERK1 and ERK2 cascade
GO_1904056Biological processpositive regulation of cholangiocyte proliferation
GO_0043235Cellular componentreceptor complex
GO_0005886Cellular componentplasma membrane
GO_0005737Cellular componentcytoplasm
GO_0005515Molecular functionprotein binding
GO_0038182Molecular functionG protein-coupled bile acid receptor activity

IV. Literature review

[source]
Gene nameGPBAR1
Protein nameG-protein coupled bile acid receptor 1 (G-protein coupled receptor GPCR19) (hGPCR19) (Membrane-type receptor for bile acids) (M-BAR) (hBG37) (BG37)
SynonymsTGR5
DescriptionFUNCTION: Receptor for bile acid. Bile acid-binding induces its internalization, activation of extracellular signal-regulated kinase and intracellular cAMP production. May be involved in the suppression of macrophage functions by bile acids. .

AccessionsENST00000479077.5
ENST00000522678.5
ENST00000521462.1
Q8TDU6
ENST00000519574.2