ARHGEF1 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
natural killer cell	38 studies	36% ± 13%	Explore
CD8-positive, alpha-beta T cell	36 studies	36% ± 15%	Explore
CD4-positive, alpha-beta T cell	33 studies	36% ± 15%	Explore
B cell	30 studies	27% ± 10%	Explore
T cell	27 studies	35% ± 13%	Explore
regulatory T cell	26 studies	37% ± 14%	Explore
mature NK T cell	21 studies	35% ± 12%	Explore
non-classical monocyte	20 studies	32% ± 16%	Explore
gamma-delta T cell	18 studies	37% ± 14%	Explore
memory B cell	18 studies	28% ± 8%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	18 studies	34% ± 13%	Explore
naive B cell	17 studies	28% ± 9%	Explore
CD16-negative, CD56-bright natural killer cell, human	16 studies	40% ± 13%	Explore
CD16-positive, CD56-dim natural killer cell, human	16 studies	47% ± 14%	Explore
mucosal invariant T cell	15 studies	35% ± 13%	Explore
classical monocyte	15 studies	29% ± 13%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	14 studies	42% ± 13%	Explore
effector memory CD8-positive, alpha-beta T cell	13 studies	38% ± 14%	Explore
CD8-positive, alpha-beta memory T cell	12 studies	45% ± 11%	Explore
CD4-positive, alpha-beta memory T cell	11 studies	40% ± 11%	Explore
plasmacytoid dendritic cell	10 studies	24% ± 6%	Explore
monocyte	9 studies	24% ± 5%	Explore
dendritic cell	7 studies	31% ± 17%	Explore
T follicular helper cell	7 studies	37% ± 11%	Explore
conventional dendritic cell	6 studies	33% ± 19%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	6 studies	33% ± 8%	Explore
innate lymphoid cell	6 studies	31% ± 11%	Explore
endothelial cell	6 studies	24% ± 8%	Explore
macrophage	6 studies	23% ± 3%	Explore
effector memory CD4-positive, alpha-beta T cell	6 studies	39% ± 17%	Explore
central memory CD8-positive, alpha-beta T cell	5 studies	33% ± 9%	Explore
exhausted T cell	5 studies	47% ± 16%	Explore
plasmablast	5 studies	31% ± 14%	Explore
effector CD8-positive, alpha-beta T cell	5 studies	32% ± 8%	Explore
microglial cell	5 studies	20% ± 4%	Explore
lymphocyte	5 studies	38% ± 7%	Explore
myeloid cell	5 studies	25% ± 7%	Explore
double negative thymocyte	5 studies	45% ± 13%	Explore
CD4-positive helper T cell	4 studies	28% ± 12%	Explore
hematopoietic precursor cell	4 studies	23% ± 9%	Explore
leukocyte	4 studies	23% ± 5%	Explore
precursor B cell	4 studies	24% ± 3%	Explore
epithelial cell	4 studies	24% ± 8%	Explore
T-helper 17 cell	4 studies	36% ± 18%	Explore
immature B cell	4 studies	34% ± 9%	Explore
effector CD4-positive, alpha-beta T cell	4 studies	33% ± 5%	Explore
type II pneumocyte	4 studies	20% ± 5%	Explore
CD4-positive, alpha-beta cytotoxic T cell	3 studies	33% ± 10%	Explore
pro-B cell	3 studies	23% ± 1%	Explore
germinal center B cell	3 studies	28% ± 8%	Explore
type I pneumocyte	3 studies	18% ± 1%	Explore
astrocyte	3 studies	22% ± 0%	Explore
group 3 innate lymphoid cell	3 studies	35% ± 11%	Explore
brush cell	3 studies	24% ± 6%	Explore
oligodendrocyte	3 studies	20% ± 1%	Explore
T-helper 1 cell	3 studies	38% ± 16%	Explore
central memory CD4-positive, alpha-beta T cell	3 studies	34% ± 13%	Explore
erythrocyte	3 studies	25% ± 6%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	18 studies	34% ± 11%	Explore
lung	6 studies	20% ± 2%	Explore
brain	4 studies	18% ± 2%	Explore
liver	3 studies	21% ± 4%	Explore
intestine	3 studies	18% ± 2%	Explore
lymph node	3 studies	36% ± 6%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	6718.57	1445 / 1445	100%	43.94	183 / 183
uterus	100%	8123.97	170 / 170	100%	49.55	459 / 459
intestine	100%	10328.30	966 / 966	100%	45.88	526 / 527
skin	100%	6936.76	1808 / 1809	100%	57.19	471 / 472
thymus	100%	9382.84	653 / 653	100%	48.19	603 / 605
stomach	100%	6296.99	359 / 359	100%	40.90	285 / 286
prostate	100%	8471.56	245 / 245	100%	28.44	500 / 502
lung	100%	15281.48	578 / 578	99%	45.72	1148 / 1155
breast	100%	8795.40	459 / 459	99%	35.90	1108 / 1118
liver	100%	3711.17	226 / 226	99%	26.22	402 / 406
bladder	100%	7502.14	21 / 21	99%	44.05	499 / 504
ovary	100%	7438.61	180 / 180	98%	26.22	423 / 430
pancreas	98%	3735.29	322 / 328	100%	59.60	178 / 178
kidney	100%	6745.11	89 / 89	98%	30.09	880 / 901
adrenal gland	100%	4550.40	258 / 258	97%	21.32	222 / 230
brain	93%	3191.38	2453 / 2642	100%	29.72	703 / 705
adipose	100%	9769.73	1204 / 1204	0%	0	0 / 0
eye	0%	0	0 / 0	100%	35.99	80 / 80
lymph node	0%	0	0 / 0	100%	134.60	29 / 29
peripheral blood	100%	27493.20	929 / 929	0%	0	0 / 0
spleen	100%	36629.17	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	47.75	45 / 45
ureter	0%	0	0 / 0	100%	29.98	1 / 1
blood vessel	100%	5856.13	1333 / 1335	0%	0	0 / 0
heart	98%	3758.03	846 / 861	0%	0	0 / 0
muscle	68%	1581.79	550 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0007266	Biological process	Rho protein signal transduction
GO_0051056	Biological process	regulation of small GTPase mediated signal transduction
GO_0007186	Biological process	G protein-coupled receptor signaling pathway
GO_0005829	Cellular component	cytosol
GO_0005886	Cellular component	plasma membrane
GO_0005737	Cellular component	cytoplasm
GO_0005085	Molecular function	guanyl-nucleotide exchange factor activity
GO_0001664	Molecular function	G protein-coupled receptor binding
GO_0005515	Molecular function	protein binding
GO_0005096	Molecular function	GTPase activator activity
GO_0003723	Molecular function	RNA binding

IV. Literature review

[source]

Gene name	ARHGEF1
Protein name	ARHGEF1 Rho guanine nucleotide exchange factor 1 ARHGEF1 protein Rho guanine nucleotide exchange factor 1 (115 kDa guanine nucleotide exchange factor) (p115-RhoGEF) (p115RhoGEF) (Sub1.5)
Synonyms
Description	FUNCTION: Seems to play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13) subunits . Acts as a GTPase-activating protein (GAP) for GNA12 and GNA13, and as guanine nucleotide exchange factor (GEF) for RhoA GTPase . Activated G alpha 13/GNA13 stimulates the RhoGEF activity through interaction with the RGS-like domain . This GEF activity is inhibited by binding to activated GNA12 . Mediates angiotensin-2-induced RhoA activation . .
Accessions	ENST00000598812.5 ENST00000594521.5 ENST00000698934.1 ENST00000337665.8 [Q92888-3] A0A2X0SFA4 A0A9L9PYI1 ENST00000599589.5 ENST00000706938.1 M0QZH8 Q92888 M0QYS3 M0R2C7 M0QXV6 ENST00000595723.5 ENST00000594258.1 ENST00000599846.6 ENST00000600517.1 M0R1K8 M0QYC1 ENST00000378152.8 [Q92888-4] ENST00000347545.8 [Q92888-2] ENST00000354532.8 [Q92888-1] A0A8V8TMG9 Q49AN3 M0QZR4 A0A8V8TP90 M0R3H5 ENST00000698933.1 A0A8V8TMH9 ENST00000594417.1 ENST00000698932.1

ARHGEF1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review