Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| fibroblast | 20 studies | 31% ± 12% | |
| oligodendrocyte | 16 studies | 60% ± 18% | |
| microglial cell | 11 studies | 35% ± 13% | |
| macrophage | 8 studies | 26% ± 6% | |
| pericyte | 4 studies | 23% ± 9% | |
| Schwann cell | 4 studies | 54% ± 24% | |
| glial cell | 3 studies | 35% ± 16% | |
| mesothelial cell | 3 studies | 22% ± 5% | |
| astrocyte | 3 studies | 30% ± 17% | |
| connective tissue cell | 3 studies | 24% ± 6% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| breast | 98% | 4366.63 | 452 / 459 | 94% | 20.27 | 1046 / 1118 |
| brain | 92% | 12016.57 | 2433 / 2642 | 96% | 51.30 | 674 / 705 |
| lung | 93% | 2607.06 | 537 / 578 | 94% | 22.86 | 1085 / 1155 |
| prostate | 97% | 3675.43 | 237 / 245 | 89% | 11.96 | 447 / 502 |
| bladder | 100% | 4408.95 | 21 / 21 | 80% | 10.91 | 401 / 504 |
| thymus | 92% | 2865.29 | 604 / 653 | 81% | 10.09 | 489 / 605 |
| uterus | 82% | 2481.72 | 140 / 170 | 86% | 18.18 | 395 / 459 |
| esophagus | 82% | 2585.83 | 1181 / 1445 | 85% | 14.92 | 155 / 183 |
| intestine | 91% | 3373.90 | 882 / 966 | 69% | 7.65 | 363 / 527 |
| skin | 90% | 7209.80 | 1631 / 1809 | 50% | 12.72 | 235 / 472 |
| adrenal gland | 57% | 1189.25 | 146 / 258 | 73% | 14.08 | 168 / 230 |
| ovary | 49% | 1054.86 | 89 / 180 | 79% | 10.78 | 338 / 430 |
| stomach | 43% | 1237.38 | 155 / 359 | 76% | 8.98 | 216 / 286 |
| blood vessel | 100% | 5995.08 | 1331 / 1335 | 0% | 0 | 0 / 0 |
| kidney | 37% | 933.80 | 33 / 89 | 63% | 8.36 | 564 / 901 |
| adipose | 98% | 4425.04 | 1178 / 1204 | 0% | 0 | 0 / 0 |
| pancreas | 2% | 23.03 | 5 / 328 | 93% | 15.73 | 166 / 178 |
| lymph node | 0% | 0 | 0 / 0 | 93% | 12.86 | 27 / 29 |
| tonsil | 0% | 0 | 0 / 0 | 82% | 11.15 | 37 / 45 |
| spleen | 73% | 1795.46 | 177 / 241 | 0% | 0 | 0 / 0 |
| heart | 52% | 1529.48 | 444 / 861 | 0% | 0 | 0 / 0 |
| liver | 0% | 0 | 0 / 226 | 10% | 1.42 | 42 / 406 |
| muscle | 9% | 189.05 | 73 / 803 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 3% | 0.11 | 2 / 80 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| peripheral blood | 0% | 0 | 0 / 929 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0032060 | Biological process | bleb assembly |
| GO_0014003 | Biological process | oligodendrocyte development |
| GO_0071673 | Biological process | positive regulation of smooth muscle cell chemotaxis |
| GO_1902018 | Biological process | negative regulation of cilium assembly |
| GO_0042552 | Biological process | myelination |
| GO_0051496 | Biological process | positive regulation of stress fiber assembly |
| GO_0043410 | Biological process | positive regulation of MAPK cascade |
| GO_0019222 | Biological process | regulation of metabolic process |
| GO_0021554 | Biological process | optic nerve development |
| GO_1904566 | Biological process | cellular response to 1-oleoyl-sn-glycerol 3-phosphate |
| GO_0007186 | Biological process | G protein-coupled receptor signaling pathway |
| GO_0022008 | Biological process | neurogenesis |
| GO_0010977 | Biological process | negative regulation of neuron projection development |
| GO_0007204 | Biological process | positive regulation of cytosolic calcium ion concentration |
| GO_0007193 | Biological process | adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway |
| GO_0043123 | Biological process | positive regulation of canonical NF-kappaB signal transduction |
| GO_0060999 | Biological process | positive regulation of dendritic spine development |
| GO_0099149 | Biological process | regulation of postsynaptic neurotransmitter receptor internalization |
| GO_0022038 | Biological process | corpus callosum development |
| GO_0007189 | Biological process | adenylate cyclase-activating G protein-coupled receptor signaling pathway |
| GO_0071453 | Biological process | cellular response to oxygen levels |
| GO_0021549 | Biological process | cerebellum development |
| GO_0098693 | Biological process | regulation of synaptic vesicle cycle |
| GO_0008360 | Biological process | regulation of cell shape |
| GO_0043951 | Biological process | negative regulation of cAMP-mediated signaling |
| GO_0035025 | Biological process | positive regulation of Rho protein signal transduction |
| GO_0043065 | Biological process | positive regulation of apoptotic process |
| GO_0060326 | Biological process | cell chemotaxis |
| GO_0098978 | Cellular component | glutamatergic synapse |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0043197 | Cellular component | dendritic spine |
| GO_0030139 | Cellular component | endocytic vesicle |
| GO_0043198 | Cellular component | dendritic shaft |
| GO_0043025 | Cellular component | neuronal cell body |
| GO_0042734 | Cellular component | presynaptic membrane |
| GO_0098982 | Cellular component | GABA-ergic synapse |
| GO_0009986 | Cellular component | cell surface |
| GO_0005737 | Cellular component | cytoplasm |
| GO_0045211 | Cellular component | postsynaptic membrane |
| GO_0005768 | Cellular component | endosome |
| GO_0004930 | Molecular function | G protein-coupled receptor activity |
| GO_0001965 | Molecular function | G-protein alpha-subunit binding |
| GO_0030165 | Molecular function | PDZ domain binding |
| GO_0070915 | Molecular function | lysophosphatidic acid receptor activity |
| GO_0035727 | Molecular function | lysophosphatidic acid binding |
| GO_0005515 | Molecular function | protein binding |
| Gene name | LPAR1 |
| Protein name | Lysophosphatidic acid receptor 1 (Lysophosphatidic acid receptor Edg-2) Lysophosphatidic acid receptor 1 (LPA receptor 1) (LPA-1) (Lysophosphatidic acid receptor Edg-2) |
| Synonyms | EDG2 LPA1 |
| Description | FUNCTION: Receptor for lysophosphatidic acid (LPA) . Plays a role in the reorganization of the actin cytoskeleton, cell migration, differentiation and proliferation, and thereby contributes to the responses to tissue damage and infectious agents. Activates downstream signaling cascades via the G(i)/G(o), G(12)/G(13), and G(q) families of heteromeric G proteins. Signaling inhibits adenylyl cyclase activity and decreases cellular cAMP levels . Signaling triggers an increase of cytoplasmic Ca(2+) levels . Activates RALA; this leads to the activation of phospholipase C (PLC) and the formation of inositol 1,4,5-trisphosphate . Signaling mediates activation of down-stream MAP kinases (By similarity). Contributes to the regulation of cell shape. Promotes Rho-dependent reorganization of the actin cytoskeleton in neuronal cells and neurite retraction . Promotes the activation of Rho and the formation of actin stress fibers . Promotes formation of lamellipodia at the leading edge of migrating cells via activation of RAC1 (By similarity). Through its function as LPA receptor, plays a role in chemotaxis and cell migration, including responses to injury and wounding . Plays a role in triggering inflammation in response to bacterial lipopolysaccharide (LPS) via its interaction with CD14. Promotes cell proliferation in response to LPA (By similarity). Inhibits the intracellular ciliogenesis pathway in response to LPA and through AKT1 activation . Required for normal skeleton development. May play a role in osteoblast differentiation. Required for normal brain development. Required for normal proliferation, survival and maturation of newly formed neurons in the adult dentate gyrus. Plays a role in pain perception and in the initiation of neuropathic pain (By similarity). . |
| Accessions | ENST00000374430.6 [Q92633-1] ENST00000374431.7 [Q92633-1] ENST00000441240.1 ENST00000358883.8 [Q92633-1] B1AP63 Q6GPG7 ENST00000683809.1 [Q92633-1] Q92633 |
