CALM2 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
B cell	45 studies	59% ± 15%	Explore
macrophage	43 studies	66% ± 21%	Explore
natural killer cell	41 studies	57% ± 17%	Explore
endothelial cell	40 studies	63% ± 21%	Explore
fibroblast	40 studies	72% ± 23%	Explore
T cell	36 studies	58% ± 20%	Explore
CD8-positive, alpha-beta T cell	36 studies	59% ± 17%	Explore
pericyte	35 studies	77% ± 26%	Explore
CD4-positive, alpha-beta T cell	32 studies	58% ± 17%	Explore
smooth muscle cell	31 studies	75% ± 26%	Explore
conventional dendritic cell	30 studies	78% ± 14%	Explore
dendritic cell	28 studies	63% ± 22%	Explore
classical monocyte	28 studies	68% ± 18%	Explore
regulatory T cell	26 studies	60% ± 15%	Explore
monocyte	25 studies	62% ± 21%	Explore
non-classical monocyte	25 studies	82% ± 16%	Explore
plasmacytoid dendritic cell	25 studies	75% ± 17%	Explore
epithelial cell	24 studies	71% ± 24%	Explore
mast cell	23 studies	56% ± 22%	Explore
endothelial cell of lymphatic vessel	21 studies	73% ± 18%	Explore
plasma cell	20 studies	46% ± 19%	Explore
mature NK T cell	20 studies	55% ± 16%	Explore
memory B cell	20 studies	63% ± 12%	Explore
basal cell	20 studies	73% ± 18%	Explore
connective tissue cell	20 studies	74% ± 21%	Explore
gamma-delta T cell	19 studies	58% ± 18%	Explore
naive B cell	19 studies	49% ± 14%	Explore
ciliated cell	18 studies	82% ± 19%	Explore
astrocyte	17 studies	60% ± 19%	Explore
mucosal invariant T cell	16 studies	48% ± 14%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	16 studies	48% ± 15%	Explore
CD16-positive, CD56-dim natural killer cell, human	15 studies	54% ± 13%	Explore
myeloid cell	15 studies	63% ± 23%	Explore
CD16-negative, CD56-bright natural killer cell, human	14 studies	55% ± 17%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	14 studies	53% ± 16%	Explore
capillary endothelial cell	14 studies	54% ± 15%	Explore
myofibroblast cell	14 studies	83% ± 13%	Explore
microglial cell	14 studies	60% ± 25%	Explore
endothelial cell of artery	13 studies	65% ± 15%	Explore
vein endothelial cell	13 studies	62% ± 20%	Explore
innate lymphoid cell	12 studies	60% ± 20%	Explore
CD4-positive, alpha-beta memory T cell	12 studies	56% ± 17%	Explore
CD8-positive, alpha-beta memory T cell	12 studies	59% ± 18%	Explore
secretory cell	12 studies	74% ± 20%	Explore
oligodendrocyte	12 studies	53% ± 17%	Explore
plasmablast	11 studies	54% ± 19%	Explore
effector memory CD8-positive, alpha-beta T cell	11 studies	55% ± 18%	Explore
progenitor cell	11 studies	72% ± 22%	Explore
goblet cell	11 studies	71% ± 23%	Explore
mesothelial cell	11 studies	69% ± 26%	Explore
endothelial cell of vascular tree	11 studies	78% ± 16%	Explore
type I pneumocyte	10 studies	72% ± 25%	Explore
club cell	10 studies	62% ± 26%	Explore
neutrophil	10 studies	46% ± 19%	Explore
oligodendrocyte precursor cell	10 studies	58% ± 21%	Explore
type II pneumocyte	9 studies	67% ± 28%	Explore
platelet	9 studies	47% ± 16%	Explore
glutamatergic neuron	9 studies	69% ± 23%	Explore
T follicular helper cell	9 studies	58% ± 15%	Explore
effector CD8-positive, alpha-beta T cell	8 studies	63% ± 20%	Explore
leukocyte	8 studies	70% ± 11%	Explore
abnormal cell	8 studies	79% ± 12%	Explore
amacrine cell	8 studies	65% ± 26%	Explore
retinal rod cell	8 studies	54% ± 27%	Explore
hematopoietic stem cell	8 studies	66% ± 14%	Explore
brush cell	8 studies	76% ± 13%	Explore
erythrocyte	8 studies	49% ± 26%	Explore
ionocyte	7 studies	85% ± 11%	Explore
respiratory goblet cell	7 studies	51% ± 22%	Explore
mononuclear phagocyte	7 studies	72% ± 26%	Explore
GABAergic neuron	7 studies	52% ± 25%	Explore
epithelial cell of proximal tubule	7 studies	51% ± 19%	Explore
enterocyte	7 studies	74% ± 17%	Explore
enteroendocrine cell	7 studies	68% ± 31%	Explore
retinal ganglion cell	7 studies	83% ± 22%	Explore
precursor B cell	7 studies	65% ± 19%	Explore
neuron	7 studies	76% ± 19%	Explore
alveolar macrophage	6 studies	71% ± 23%	Explore
effector CD4-positive, alpha-beta T cell	6 studies	73% ± 9%	Explore
kidney loop of Henle epithelial cell	6 studies	78% ± 13%	Explore
renal alpha-intercalated cell	6 studies	91% ± 3%	Explore
erythroblast	6 studies	65% ± 23%	Explore
IgG plasma cell	6 studies	27% ± 4%	Explore
transit amplifying cell	6 studies	60% ± 28%	Explore
retinal cone cell	6 studies	64% ± 25%	Explore
glial cell	6 studies	74% ± 25%	Explore
immature B cell	6 studies	55% ± 23%	Explore
retina horizontal cell	6 studies	66% ± 22%	Explore
Mueller cell	6 studies	71% ± 23%	Explore
intermediate monocyte	6 studies	73% ± 23%	Explore
effector memory CD4-positive, alpha-beta T cell	6 studies	66% ± 13%	Explore
interneuron	6 studies	75% ± 14%	Explore
CD4-positive helper T cell	5 studies	53% ± 18%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	5 studies	48% ± 15%	Explore
hematopoietic precursor cell	5 studies	68% ± 21%	Explore
exhausted T cell	5 studies	64% ± 11%	Explore
kidney distal convoluted tubule epithelial cell	5 studies	89% ± 6%	Explore
megakaryocyte	5 studies	74% ± 15%	Explore
intestinal crypt stem cell	5 studies	66% ± 24%	Explore
IgA plasma cell	5 studies	29% ± 1%	Explore
retinal bipolar neuron	5 studies	64% ± 29%	Explore
OFF-bipolar cell	5 studies	69% ± 26%	Explore
ON-bipolar cell	5 studies	74% ± 24%	Explore
pro-B cell	5 studies	62% ± 17%	Explore
neuroendocrine cell	5 studies	88% ± 16%	Explore
T-helper 17 cell	5 studies	66% ± 14%	Explore
double negative thymocyte	5 studies	72% ± 11%	Explore
granulocyte	5 studies	69% ± 24%	Explore
CD4-positive, alpha-beta cytotoxic T cell	4 studies	48% ± 28%	Explore
central memory CD8-positive, alpha-beta T cell	4 studies	49% ± 18%	Explore
deuterosomal cell	4 studies	79% ± 11%	Explore
duct epithelial cell	4 studies	81% ± 9%	Explore
precursor cell	4 studies	68% ± 17%	Explore
pancreatic A cell	4 studies	89% ± 8%	Explore
type B pancreatic cell	4 studies	89% ± 6%	Explore
glomerular endothelial cell	4 studies	45% ± 15%	Explore
podocyte	4 studies	95% ± 3%	Explore
GABAergic amacrine cell	4 studies	68% ± 24%	Explore
glycinergic amacrine cell	4 studies	64% ± 27%	Explore
lymphocyte	4 studies	61% ± 27%	Explore
retinal pigment epithelial cell	4 studies	62% ± 23%	Explore
adventitial cell	4 studies	67% ± 19%	Explore
mucus secreting cell	4 studies	78% ± 18%	Explore
acinar cell	4 studies	54% ± 24%	Explore
germinal center B cell	4 studies	63% ± 8%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	90% ± 8%	Explore
group 3 innate lymphoid cell	4 studies	69% ± 10%	Explore
melanocyte	4 studies	78% ± 13%	Explore
T-helper 1 cell	4 studies	66% ± 14%	Explore
pancreatic D cell	3 studies	91% ± 8%	Explore
monocyte-derived dendritic cell	3 studies	78% ± 24%	Explore
kidney connecting tubule epithelial cell	3 studies	84% ± 8%	Explore
renal beta-intercalated cell	3 studies	96% ± 1%	Explore
neural crest cell	3 studies	85% ± 15%	Explore
GABAergic interneuron	3 studies	40% ± 18%	Explore
renal principal cell	3 studies	78% ± 5%	Explore
thymocyte	3 studies	63% ± 27%	Explore
extravillous trophoblast	3 studies	65% ± 17%	Explore
placental villous trophoblast	3 studies	66% ± 29%	Explore
serous secreting cell	3 studies	70% ± 12%	Explore
tissue-resident macrophage	3 studies	63% ± 23%	Explore
intraepithelial lymphocyte	3 studies	65% ± 16%	Explore
rod bipolar cell	3 studies	83% ± 15%	Explore
inflammatory macrophage	3 studies	64% ± 10%	Explore
cardiac muscle cell	3 studies	28% ± 2%	Explore
muscle cell	3 studies	61% ± 19%	Explore
myoepithelial cell	3 studies	80% ± 4%	Explore
luminal cell of prostate epithelium	3 studies	85% ± 3%	Explore
IgM plasma cell	3 studies	28% ± 8%	Explore
pancreatic ductal cell	3 studies	94% ± 3%	Explore
neural progenitor cell	3 studies	56% ± 20%	Explore
ependymal cell	3 studies	53% ± 18%	Explore
megakaryocyte-erythroid progenitor cell	3 studies	84% ± 10%	Explore
hepatocyte	3 studies	61% ± 20%	Explore
keratinocyte	3 studies	77% ± 15%	Explore
central memory CD4-positive, alpha-beta T cell	3 studies	57% ± 7%	Explore
progenitor cell of mammary luminal epithelium	3 studies	88% ± 3%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	20 studies	59% ± 14%	Explore
lung	18 studies	65% ± 17%	Explore
brain	15 studies	57% ± 23%	Explore
intestine	13 studies	61% ± 21%	Explore
eye	11 studies	64% ± 24%	Explore
kidney	9 studies	62% ± 18%	Explore
bone marrow	7 studies	42% ± 19%	Explore
lymph node	6 studies	66% ± 18%	Explore
pancreas	5 studies	76% ± 19%	Explore
uterus	5 studies	81% ± 13%	Explore
liver	5 studies	67% ± 14%	Explore
placenta	4 studies	66% ± 21%	Explore
heart	4 studies	33% ± 12%	Explore
adipose	4 studies	34% ± 17%	Explore
prostate	4 studies	72% ± 20%	Explore
breast	4 studies	80% ± 8%	Explore
adrenal gland	3 studies	63% ± 6%	Explore
esophagus	3 studies	63% ± 20%	Explore
skin	3 studies	77% ± 10%	Explore
thymus	3 studies	75% ± 22%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
brain	100%	57352.23	2642 / 2642	100%	289.63	705 / 705
esophagus	100%	27856.87	1445 / 1445	100%	145.53	183 / 183
ovary	100%	22368.46	180 / 180	100%	203.67	430 / 430
breast	100%	24074.63	459 / 459	100%	285.55	1116 / 1118
uterus	100%	26992.53	170 / 170	100%	187.59	458 / 459
bladder	100%	22153.52	21 / 21	100%	180.59	502 / 504
kidney	100%	20467.11	89 / 89	100%	135.15	897 / 901
thymus	100%	20904.10	651 / 653	100%	244.78	604 / 605
lung	99%	25127.93	575 / 578	100%	224.30	1154 / 1155
prostate	100%	21681.33	244 / 245	100%	189.40	500 / 502
adrenal gland	100%	28026.40	258 / 258	99%	476.93	228 / 230
intestine	100%	32992.92	966 / 966	99%	198.54	521 / 527
skin	100%	20912.05	1801 / 1809	97%	169.06	459 / 472
stomach	92%	16577.29	331 / 359	100%	170.94	285 / 286
liver	92%	10821.90	209 / 226	99%	110.92	401 / 406
pancreas	59%	5212.49	193 / 328	99%	209.54	177 / 178
lymph node	0%	0	0 / 0	100%	164.69	29 / 29
spleen	100%	30132.95	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	153.89	45 / 45
ureter	0%	0	0 / 0	100%	64.55	1 / 1
adipose	100%	23200.06	1203 / 1204	0%	0	0 / 0
blood vessel	100%	34536.08	1331 / 1335	0%	0	0 / 0
heart	93%	14477.36	804 / 861	0%	0	0 / 0
eye	0%	0	0 / 0	84%	72.78	67 / 80
peripheral blood	81%	18015.57	754 / 929	0%	0	0 / 0
muscle	76%	7349.49	613 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_1901020	Biological process	negative regulation of calcium ion transmembrane transporter activity
GO_0060315	Biological process	negative regulation of ryanodine-sensitive calcium-release channel activity
GO_0051343	Biological process	positive regulation of cyclic-nucleotide phosphodiesterase activity
GO_0002027	Biological process	regulation of heart rate
GO_0032465	Biological process	regulation of cytokinesis
GO_0060316	Biological process	positive regulation of ryanodine-sensitive calcium-release channel activity
GO_0010881	Biological process	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
GO_0010801	Biological process	negative regulation of peptidyl-threonine phosphorylation
GO_0007186	Biological process	G protein-coupled receptor signaling pathway
GO_0050848	Biological process	regulation of calcium-mediated signaling
GO_0021762	Biological process	substantia nigra development
GO_0031954	Biological process	positive regulation of protein autophosphorylation
GO_0000086	Biological process	G2/M transition of mitotic cell cycle
GO_0010880	Biological process	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
GO_0032516	Biological process	positive regulation of phosphoprotein phosphatase activity
GO_0010800	Biological process	positive regulation of peptidyl-threonine phosphorylation
GO_1905913	Biological process	negative regulation of calcium ion export across plasma membrane
GO_1901844	Biological process	regulation of cell communication by electrical coupling involved in cardiac conduction
GO_0055117	Biological process	regulation of cardiac muscle contraction
GO_0071902	Biological process	positive regulation of protein serine/threonine kinase activity
GO_0051592	Biological process	response to calcium ion
GO_0035307	Biological process	positive regulation of protein dephosphorylation
GO_0005513	Biological process	detection of calcium ion
GO_0005876	Cellular component	spindle microtubule
GO_1902494	Cellular component	catalytic complex
GO_0043209	Cellular component	myelin sheath
GO_0031982	Cellular component	vesicle
GO_0005886	Cellular component	plasma membrane
GO_0000922	Cellular component	spindle pole
GO_0016020	Cellular component	membrane
GO_0005813	Cellular component	centrosome
GO_0032991	Cellular component	protein-containing complex
GO_0030017	Cellular component	sarcomere
GO_0034704	Cellular component	calcium channel complex
GO_0005737	Cellular component	cytoplasm
GO_0097225	Cellular component	sperm midpiece
GO_0008076	Cellular component	voltage-gated potassium channel complex
GO_0005634	Cellular component	nucleus
GO_0031432	Molecular function	titin binding
GO_0019901	Molecular function	protein kinase binding
GO_0043539	Molecular function	protein serine/threonine kinase activator activity
GO_0048306	Molecular function	calcium-dependent protein binding
GO_0044325	Molecular function	transmembrane transporter binding
GO_0019855	Molecular function	calcium channel inhibitor activity
GO_0008179	Molecular function	adenylate cyclase binding
GO_0072542	Molecular function	protein phosphatase activator activity
GO_0005509	Molecular function	calcium ion binding
GO_0005515	Molecular function	protein binding
GO_0010856	Molecular function	adenylate cyclase activator activity

IV. Literature review

[source]

Gene name	CALM2
Protein name	Calmodulin 2 Calmodulin-2
Synonyms	CAM2 CAMB
Description	FUNCTION: Calmodulin acts as part of a calcium signal transduction pathway by mediating the control of a large number of enzymes, ion channels, aquaporins and other proteins through calcium-binding . Calcium-binding is required for the activation of calmodulin . Among the enzymes to be stimulated by the calmodulin-calcium complex are a number of protein kinases, such as myosin light-chain kinases and calmodulin-dependent protein kinase type II (CaMK2), and phosphatases . Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis . Mediates calcium-dependent inactivation of CACNA1C . Positively regulates calcium-activated potassium channel activity of KCNN2 . .; FUNCTION: (Microbial infection) Required for C.violaceum CopC and S.flexneri OspC3 arginine ADP-riboxanase activity. .
Accessions	E7EMB3 ENST00000484408.5 ENST00000409563.5 ENST00000652974.1 A0A590UJC0 P0DP24 A0A590UJE2 F8WBR5 ENST00000432899.5 ENST00000272298.12 ENST00000489742.1 A0A590UJI2

CALM2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review