Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| endothelial cell | 35 studies | 40% ± 17% | |
| astrocyte | 16 studies | 65% ± 22% | |
| pericyte | 14 studies | 32% ± 11% | |
| oligodendrocyte precursor cell | 14 studies | 54% ± 21% | |
| oligodendrocyte | 13 studies | 39% ± 14% | |
| endothelial cell of artery | 11 studies | 38% ± 16% | |
| capillary endothelial cell | 10 studies | 25% ± 12% | |
| endothelial cell of lymphatic vessel | 9 studies | 34% ± 17% | |
| fibroblast | 8 studies | 28% ± 10% | |
| vein endothelial cell | 8 studies | 38% ± 25% | |
| GABAergic neuron | 7 studies | 38% ± 12% | |
| adipocyte | 6 studies | 28% ± 6% | |
| Mueller cell | 6 studies | 40% ± 15% | |
| smooth muscle cell | 5 studies | 29% ± 13% | |
| endothelial cell of vascular tree | 4 studies | 52% ± 23% | |
| endothelial cell of sinusoid | 3 studies | 34% ± 14% | |
| glomerular endothelial cell | 3 studies | 27% ± 1% | |
| GABAergic interneuron | 3 studies | 35% ± 26% | |
| microglial cell | 3 studies | 41% ± 19% | |
| ependymal cell | 3 studies | 57% ± 17% | |
| glutamatergic neuron | 3 studies | 28% ± 11% | |
| interneuron | 3 studies | 41% ± 23% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| brain | 13 studies | 28% ± 11% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| brain | 99% | 2744.36 | 2626 / 2642 | 98% | 13.52 | 690 / 705 |
| thymus | 100% | 4496.69 | 652 / 653 | 60% | 3.27 | 366 / 605 |
| breast | 100% | 3154.96 | 458 / 459 | 51% | 2.38 | 571 / 1118 |
| ovary | 82% | 779.16 | 147 / 180 | 66% | 4.22 | 282 / 430 |
| prostate | 98% | 1344.16 | 241 / 245 | 46% | 1.67 | 229 / 502 |
| lung | 100% | 2537.26 | 577 / 578 | 29% | 1.43 | 334 / 1155 |
| esophagus | 80% | 1086.46 | 1155 / 1445 | 44% | 1.99 | 81 / 183 |
| uterus | 98% | 1460.98 | 166 / 170 | 25% | 1.87 | 117 / 459 |
| kidney | 64% | 501.97 | 57 / 89 | 59% | 10.98 | 532 / 901 |
| bladder | 95% | 1507.86 | 20 / 21 | 12% | 0.56 | 62 / 504 |
| intestine | 93% | 1233.61 | 896 / 966 | 15% | 0.63 | 77 / 527 |
| adipose | 100% | 3721.48 | 1204 / 1204 | 0% | 0 | 0 / 0 |
| blood vessel | 98% | 1726.48 | 1306 / 1335 | 0% | 0 | 0 / 0 |
| heart | 97% | 1063.12 | 833 / 861 | 0% | 0 | 0 / 0 |
| stomach | 66% | 646.85 | 238 / 359 | 29% | 1.44 | 83 / 286 |
| muscle | 71% | 473.24 | 572 / 803 | 0% | 0 | 0 / 0 |
| adrenal gland | 47% | 302.40 | 121 / 258 | 22% | 0.78 | 51 / 230 |
| spleen | 68% | 483.27 | 163 / 241 | 0% | 0 | 0 / 0 |
| skin | 57% | 497.17 | 1030 / 1809 | 9% | 0.48 | 44 / 472 |
| pancreas | 14% | 76.68 | 45 / 328 | 52% | 2.24 | 93 / 178 |
| liver | 6% | 32.81 | 14 / 226 | 11% | 0.50 | 45 / 406 |
| tonsil | 0% | 0 | 0 / 0 | 11% | 0.31 | 5 / 45 |
| lymph node | 0% | 0 | 0 / 0 | 3% | 0.31 | 1 / 29 |
| peripheral blood | 0% | 0.42 | 1 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 80 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0008344 | Biological process | adult locomotory behavior |
| GO_0051056 | Biological process | regulation of small GTPase mediated signal transduction |
| GO_0043491 | Biological process | phosphatidylinositol 3-kinase/protein kinase B signal transduction |
| GO_0007186 | Biological process | G protein-coupled receptor signaling pathway |
| GO_0043547 | Biological process | positive regulation of GTPase activity |
| GO_0048813 | Biological process | dendrite morphogenesis |
| GO_0023051 | Biological process | regulation of signaling |
| GO_0005829 | Cellular component | cytosol |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0005085 | Molecular function | guanyl-nucleotide exchange factor activity |
| GO_0005096 | Molecular function | GTPase activator activity |
| Gene name | PREX2 |
| Protein name | PtdIns(3,4,5)-dependent rac exchanger-2 PREX2 Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 protein (P-Rex2) (PtdIns(3,4,5)-dependent Rac exchanger 2) (DEP domain-containing protein 2) |
| Synonyms | DEPDC2 |
| Description | FUNCTION: Functions as a RAC1 guanine nucleotide exchange factor (GEF), activating Rac proteins by exchanging bound GDP for free GTP. Its activity is synergistically activated by phosphatidylinositol 3,4,5-trisphosphate and the beta gamma subunits of heterotrimeric G protein. Mediates the activation of RAC1 in a PI3K-dependent manner. May be an important mediator of Rac signaling, acting directly downstream of both G protein-coupled receptors and phosphoinositide 3-kinase. . |
| Accessions | Q56UR8 ENST00000288368.5 [Q70Z35-1] A0A2X0SZ31 Q70Z35 |