PREX2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0008344Biological processadult locomotory behavior
GO_0051056Biological processregulation of small GTPase mediated signal transduction
GO_0043491Biological processphosphatidylinositol 3-kinase/protein kinase B signal transduction
GO_0007186Biological processG protein-coupled receptor signaling pathway
GO_0043547Biological processpositive regulation of GTPase activity
GO_0048813Biological processdendrite morphogenesis
GO_0023051Biological processregulation of signaling
GO_0005829Cellular componentcytosol
GO_0005886Cellular componentplasma membrane
GO_0005085Molecular functionguanyl-nucleotide exchange factor activity
GO_0005096Molecular functionGTPase activator activity

IV. Literature review

[source]
Gene namePREX2
Protein namePtdIns(3,4,5)-dependent rac exchanger-2
PREX2
Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 protein (P-Rex2) (PtdIns(3,4,5)-dependent Rac exchanger 2) (DEP domain-containing protein 2)
SynonymsDEPDC2
DescriptionFUNCTION: Functions as a RAC1 guanine nucleotide exchange factor (GEF), activating Rac proteins by exchanging bound GDP for free GTP. Its activity is synergistically activated by phosphatidylinositol 3,4,5-trisphosphate and the beta gamma subunits of heterotrimeric G protein. Mediates the activation of RAC1 in a PI3K-dependent manner. May be an important mediator of Rac signaling, acting directly downstream of both G protein-coupled receptors and phosphoinositide 3-kinase. .

AccessionsQ56UR8
ENST00000288368.5 [Q70Z35-1]
A0A2X0SZ31
Q70Z35