NMU report

I. Expression across cell types

Insufficient scRNA-seq data for expression of NMU at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of NMU at tissue level.

III. Associated gene sets

GO_2000821Biological processregulation of grooming behavior
GO_0097009Biological processenergy homeostasis
GO_0001659Biological processtemperature homeostasis
GO_0050806Biological processpositive regulation of synaptic transmission
GO_0007186Biological processG protein-coupled receptor signaling pathway
GO_0007218Biological processneuropeptide signaling pathway
GO_0045987Biological processpositive regulation of smooth muscle contraction
GO_0060259Biological processregulation of feeding behavior
GO_0043195Cellular componentterminal bouton
GO_0005576Cellular componentextracellular region
GO_0031839Molecular functiontype 1 neuromedin U receptor binding
GO_0042922Molecular functionneuromedin U receptor binding
GO_0005102Molecular functionsignaling receptor binding
GO_0005515Molecular functionprotein binding
GO_0031840Molecular functiontype 2 neuromedin U receptor binding

IV. Literature review

[source]
Gene nameNMU
Protein nameNeuromedin U, isoform CRA_b (Neuromedin U-related peptide/neuromedin U preproprotein)
Neuromedin U
Neuromedin-U [Cleaved into: Neuromedin precursor-related peptide 36 (NURP36); Neuromedin precursor-related peptide 33 (NURP33); Neuromedin-U-25 (NmU-25)]
SynonymshCG_20599
DescriptionFUNCTION: [Neuromedin-U-25]: Ligand for receptors NMUR1 and NMUR2 (By similarity). Stimulates muscle contractions of specific regions of the gastrointestinal tract. In humans, NmU stimulates contractions of the ileum and urinary bladder. .; FUNCTION: [Neuromedin precursor-related peptide 33]: Does not function as a ligand for either NMUR1 or NMUR2. Indirectly induces prolactin release although its potency is much lower than that of neuromedin precursor-related peptide 36. .; FUNCTION: [Neuromedin precursor-related peptide 36]: Does not function as a ligand for either NMUR1 or NMUR2. Indirectly induces prolactin release from lactotroph cells in the pituitary gland, probably via the hypothalamic dopaminergic system. .

AccessionsENST00000264218.7
P48645
ENST00000507338.1
Q86WB5
Q1EHW1
ENST00000505262.5
E9PDJ7
Q86WB6
Q9NYL6
Q86WB4
ENST00000511469.5
D6RBC9
A0A0B4J202
A0A250SH36