GPR183 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0002407Biological processdendritic cell chemotaxis
GO_0006955Biological processimmune response
GO_0002250Biological processadaptive immune response
GO_0007186Biological processG protein-coupled receptor signaling pathway
GO_0002312Biological processB cell activation involved in immune response
GO_0010818Biological processT cell chemotaxis
GO_0036145Biological processdendritic cell homeostasis
GO_0070374Biological processpositive regulation of ERK1 and ERK2 cascade
GO_0030595Biological processleukocyte chemotaxis
GO_0061470Biological processT follicular helper cell differentiation
GO_0030890Biological processpositive regulation of B cell proliferation
GO_0030316Biological processosteoclast differentiation
GO_0002313Biological processmature B cell differentiation involved in immune response
GO_0006959Biological processhumoral immune response
GO_2000458Biological processregulation of astrocyte chemotaxis
GO_0005886Cellular componentplasma membrane
GO_0004930Molecular functionG protein-coupled receptor activity
GO_0008142Molecular functionoxysterol binding

IV. Literature review

[source]
Gene nameGPR183
Protein nameG-protein coupled receptor 183 (Epstein-Barr virus-induced G-protein coupled receptor 2) (EBI2) (EBV-induced G-protein coupled receptor 2) (hEBI2)
SynonymsEBI2
DescriptionFUNCTION: G-protein coupled receptor expressed in lymphocytes that acts as a chemotactic receptor for B-cells, T-cells, splenic dendritic cells, monocytes/macrophages and astrocytes (By similarity). Receptor for oxysterol 7-alpha,25-dihydroxycholesterol (7-alpha,25-OHC) and other related oxysterols . Mediates cell positioning and movement of a number of cells by binding the 7-alpha,25-OHC ligand that forms a chemotactic gradient (By similarity). Binding of 7-alpha,25-OHC mediates the correct localization of B-cells during humoral immune responses (By similarity). Guides B-cell movement along the B-cell zone-T-cell zone boundary and later to interfollicular and outer follicular regions (By similarity). Its specific expression during B-cell maturation helps position B-cells appropriately for mounting T-dependent antibody responses (By similarity). Collaborates with CXCR5 to mediate B-cell migration; probably by forming a heterodimer with CXCR5 that affects the interaction between of CXCL13 and CXCR5 . Also acts as a chemotactic receptor for some T-cells upon binding to 7-alpha,25-OHC ligand (By similarity). Promotes follicular helper T (Tfh) cells differentiation by positioning activated T-cells at the follicle-T-zone interface, promoting contact of newly activated CD4 T-cells with activated dendritic cells and exposing them to Tfh-cell-promoting inducible costimulator (ICOS) ligand (By similarity). Expression in splenic dendritic cells is required for their homeostasis, localization and ability to induce B- and T-cell responses: GPR183 acts as a chemotactic receptor in dendritic cells that mediates the accumulation of CD4(+) dendritic cells in bridging channels (By similarity). Regulates migration of astrocytes and is involved in communication between astrocytes and macrophages . Promotes osteoclast precursor migration to bone surfaces (By similarity). Signals constitutively through G(i)-alpha, but not G(s)-alpha or G(q)-alpha . Signals constitutively also via MAPK1/3 (ERK1/2) (By similarity). .

AccessionsENST00000376414.5
P32249