ADGRE2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0043304Biological processregulation of mast cell degranulation
GO_0071621Biological processgranulocyte chemotaxis
GO_0007186Biological processG protein-coupled receptor signaling pathway
GO_0007189Biological processadenylate cyclase-activating G protein-coupled receptor signaling pathway
GO_0006954Biological processinflammatory response
GO_0007155Biological processcell adhesion
GO_0016477Biological processcell migration
GO_0007166Biological processcell surface receptor signaling pathway
GO_0032587Cellular componentruffle membrane
GO_0031256Cellular componentleading edge membrane
GO_0005886Cellular componentplasma membrane
GO_0016020Cellular componentmembrane
GO_0035374Molecular functionchondroitin sulfate binding
GO_0004930Molecular functionG protein-coupled receptor activity
GO_0005509Molecular functioncalcium ion binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameADGRE2
Protein nameEMR2 protein
Adhesion G protein-coupled receptor E2 (cDNA FLJ60183, highly similar to Homo sapiens egf-like module containing, mucin-like, hormone receptor-like 2, transcript variant 6, mRNA)
Adhesion G protein-coupled receptor E2 (EGF-like module receptor 2) (EGF-like module-containing mucin-like hormone receptor-like 2) (CD antigen CD312)
Egf-like module containing, mucin-like, hormone receptor-like 2
Adhesion G protein-coupled receptor E2
SynonymsEMR2
DescriptionFUNCTION: Cell surface receptor that binds to the chondroitin sulfate moiety of glycosaminoglycan chains and promotes cell attachment. Promotes granulocyte chemotaxis, degranulation and adhesion. In macrophages, promotes the release of inflammatory cytokines, including IL8 and TNF. Signals probably through G-proteins. Is a regulator of mast cell degranulation . .

AccessionsENST00000392965.7 [Q9UHX3-6]
ENST00000595839.5 [Q9UHX3-5]
ENST00000595208.5
ENST00000392962.3
ENST00000596991.6 [Q9UHX3-2]
ENST00000315576.8 [Q9UHX3-1]
M0QY55
M0R0K5
Q7Z618
A0JNV7
B4DWB8
ENST00000594076.5 [Q9UHX3-4]
ENST00000594294.5 [Q9UHX3-3]
ENST00000601345.5
Q9UHX3