Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| glutamatergic neuron | 11 studies | 52% ± 22% | |
| GABAergic neuron | 6 studies | 40% ± 13% | |
| granule cell | 4 studies | 65% ± 20% | |
| interneuron | 4 studies | 38% ± 25% | |
| retinal rod cell | 4 studies | 41% ± 15% | |
| neuron | 3 studies | 22% ± 5% | |
| GABAergic interneuron | 3 studies | 25% ± 3% | |
| retinal ganglion cell | 3 studies | 31% ± 18% | |
| astrocyte | 3 studies | 36% ± 27% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| brain | 94% | 1461.87 | 2485 / 2642 | 62% | 2.64 | 439 / 705 |
| heart | 39% | 115.00 | 337 / 861 | 0% | 0 | 0 / 0 |
| kidney | 19% | 33.11 | 17 / 89 | 5% | 0.43 | 49 / 901 |
| skin | 1% | 0.63 | 13 / 1809 | 17% | 1.13 | 79 / 472 |
| thymus | 16% | 14.24 | 105 / 653 | 1% | 0.03 | 6 / 605 |
| lung | 1% | 0.84 | 6 / 578 | 5% | 0.25 | 52 / 1155 |
| ovary | 1% | 1.09 | 2 / 180 | 4% | 0.08 | 18 / 430 |
| pancreas | 0% | 0 | 0 / 328 | 4% | 0.12 | 7 / 178 |
| adrenal gland | 0% | 3.01 | 1 / 258 | 3% | 0.08 | 6 / 230 |
| uterus | 1% | 0.55 | 1 / 170 | 2% | 0.07 | 10 / 459 |
| breast | 1% | 1.04 | 6 / 459 | 0% | 0.00 | 3 / 1118 |
| eye | 0% | 0 | 0 / 0 | 1% | 0.05 | 1 / 80 |
| esophagus | 0% | 0.04 | 1 / 1445 | 1% | 0.04 | 2 / 183 |
| intestine | 0% | 0 | 0 / 966 | 1% | 0.21 | 6 / 527 |
| stomach | 0% | 0 | 0 / 359 | 1% | 0.02 | 3 / 286 |
| liver | 0% | 0 | 0 / 226 | 1% | 0.02 | 4 / 406 |
| blood vessel | 1% | 0.77 | 8 / 1335 | 0% | 0 | 0 / 0 |
| spleen | 0% | 0.28 | 1 / 241 | 0% | 0 | 0 / 0 |
| bladder | 0% | 0 | 0 / 21 | 0% | 0.01 | 2 / 504 |
| muscle | 0% | 0.46 | 3 / 803 | 0% | 0 | 0 / 0 |
| adipose | 0% | 0.05 | 1 / 1204 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 29 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| peripheral blood | 0% | 0 | 0 / 929 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| prostate | 0% | 0 | 0 / 245 | 0% | 0 | 0 / 502 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 45 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0019233 | Biological process | sensory perception of pain |
| GO_0099566 | Biological process | regulation of postsynaptic cytosolic calcium ion concentration |
| GO_0007206 | Biological process | phospholipase C-activating G protein-coupled glutamate receptor signaling pathway |
| GO_0007196 | Biological process | adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway |
| GO_0098712 | Biological process | L-glutamate import across plasma membrane |
| GO_0051930 | Biological process | regulation of sensory perception of pain |
| GO_0007216 | Biological process | G protein-coupled glutamate receptor signaling pathway |
| GO_0043410 | Biological process | positive regulation of MAPK cascade |
| GO_0051966 | Biological process | regulation of synaptic transmission, glutamatergic |
| GO_0007186 | Biological process | G protein-coupled receptor signaling pathway |
| GO_0007268 | Biological process | chemical synaptic transmission |
| GO_0071257 | Biological process | cellular response to electrical stimulus |
| GO_0060078 | Biological process | regulation of postsynaptic membrane potential |
| GO_0007626 | Biological process | locomotory behavior |
| GO_0098978 | Cellular component | glutamatergic synapse |
| GO_0098839 | Cellular component | postsynaptic density membrane |
| GO_0038037 | Cellular component | G protein-coupled receptor dimeric complex |
| GO_0098685 | Cellular component | Schaffer collateral - CA1 synapse |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0038038 | Cellular component | G protein-coupled receptor homodimeric complex |
| GO_0030425 | Cellular component | dendrite |
| GO_0005634 | Cellular component | nucleus |
| GO_0008066 | Molecular function | glutamate receptor activity |
| GO_0098872 | Molecular function | G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration |
| GO_0004930 | Molecular function | G protein-coupled receptor activity |
| GO_0099583 | Molecular function | neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration |
| GO_0099530 | Molecular function | G protein-coupled receptor activity involved in regulation of postsynaptic membrane potential |
| GO_0001640 | Molecular function | adenylate cyclase inhibiting G protein-coupled glutamate receptor activity |
| GO_0005515 | Molecular function | protein binding |
| Gene name | GRM1 |
| Protein name | Metabotropic glutamate receptor 1 (mGluR1) |
| Synonyms | GPRC1A MGLUR1 |
| Description | FUNCTION: G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling activates a phosphatidylinositol-calcium second messenger system. May participate in the central action of glutamate in the CNS, such as long-term potentiation in the hippocampus and long-term depression in the cerebellum . May function in the light response in the retina (By similarity). . |
| Accessions | ENST00000355289.8 [Q13255-3] ENST00000507907.1 [Q13255-2] ENST00000706835.1 [Q13255-1] Q13255 ENST00000282753.6 [Q13255-1] ENST00000706833.1 [Q13255-1] ENST00000361719.6 [Q13255-1] ENST00000492807.6 [Q13255-2] ENST00000706836.1 [Q13255-2] ENST00000706834.1 [Q13255-2] |
