CMKLR2 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of CMKLR2 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of CMKLR2 at tissue level.

III. Associated gene sets

GO_0007186Biological processG protein-coupled receptor signaling pathway
GO_0007218Biological processneuropeptide signaling pathway
GO_0042593Biological processglucose homeostasis
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0005654Cellular componentnucleoplasm
GO_0005886Cellular componentplasma membrane
GO_0043005Cellular componentneuron projection
GO_0042923Molecular functionneuropeptide binding
GO_0004930Molecular functionG protein-coupled receptor activity
GO_0097003Molecular functionadipokinetic hormone receptor activity
GO_0097004Molecular functionadipokinetic hormone binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameCMKLR2
Protein nameChemerin chemokine-like receptor 2 (Chemerin-like receptor 2)
Chemerin-like receptor 2 (Chemerin chemokine-like receptor 2) (Chemokine-like receptor 2) (G-protein coupled receptor 1)
SynonymsGPR1
DescriptionFUNCTION: Receptor for chemoattractant adipokine chemerin/RARRES2 suggesting a role for this receptor in the regulation of inflammation and energy homesotasis . Signals mainly via beta-arrestin pathway. Binding of RARRES2 activates weakly G proteins, calcium mobilization and MAPK1/MAPK3 (ERK1/2) phosphorylation too . Acts also as a receptor for TAFA1, mediates its effects on neuronal stem-cell proliferation and differentiation via the activation of ROCK/ERK and ROCK/STAT3 signaling pathway (By similarity). .; FUNCTION: (Microbial infection) Coreceptor for HIV-1. .

AccessionsENST00000637600.1
ENST00000451790.5
C9JQB7
C9JCK1
ENST00000437420.5
C9JKF3
ENST00000439932.5
ENST00000621141.5
ENST00000638116.1
ENST00000637075.1
ENST00000636848.1
ENST00000638027.1
ENST00000636284.1
ENST00000636896.1
ENST00000635908.1
ENST00000411719.1
C9JSU0
ENST00000636918.1
ENST00000638097.1
C9J456
ENST00000458440.1
ENST00000407325.6
ENST00000442134.1
C9JFR8
P46091