IGF2R report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0007283Biological processspermatogenesis
GO_0009791Biological processpost-embryonic development
GO_0006898Biological processreceptor-mediated endocytosis
GO_0048009Biological processinsulin-like growth factor receptor signaling pathway
GO_0007165Biological processsignal transduction
GO_0007041Biological processlysosomal transport
GO_0001889Biological processliver development
GO_0031100Biological processanimal organ regeneration
GO_1904772Biological processresponse to tetrachloromethane
GO_0044794Biological processpositive regulation by host of viral process
GO_0007186Biological processG protein-coupled receptor signaling pathway
GO_0032526Biological processresponse to retinoic acid
GO_0043065Biological processpositive regulation of apoptotic process
GO_0030667Cellular componentsecretory granule membrane
GO_0005886Cellular componentplasma membrane
GO_0005641Cellular componentnuclear envelope lumen
GO_0030139Cellular componentendocytic vesicle
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_0016020Cellular componentmembrane
GO_0005769Cellular componentearly endosome
GO_0030118Cellular componentclathrin coat
GO_0070062Cellular componentextracellular exosome
GO_0030669Cellular componentclathrin-coated endocytic vesicle membrane
GO_0005794Cellular componentGolgi apparatus
GO_0005925Cellular componentfocal adhesion
GO_0032588Cellular componenttrans-Golgi network membrane
GO_0005802Cellular componenttrans-Golgi network
GO_0009986Cellular componentcell surface
GO_0000139Cellular componentGolgi membrane
GO_0030140Cellular componenttrans-Golgi network transport vesicle
GO_0005770Cellular componentlate endosome
GO_0030133Cellular componenttransport vesicle
GO_0010008Cellular componentendosome membrane
GO_0005768Cellular componentendosome
GO_1905394Molecular functionretromer complex binding
GO_0019899Molecular functionenzyme binding
GO_0038023Molecular functionsignaling receptor activity
GO_0005537Molecular functionD-mannose binding
GO_0005520Molecular functioninsulin-like growth factor binding
GO_0001965Molecular functionG-protein alpha-subunit binding
GO_0042802Molecular functionidentical protein binding
GO_0031995Molecular functioninsulin-like growth factor II binding
GO_0001972Molecular functionretinoic acid binding
GO_0051219Molecular functionphosphoprotein binding
GO_0005515Molecular functionprotein binding
GO_0005010Molecular functioninsulin-like growth factor receptor activity

IV. Literature review

[source]
Gene nameIGF2R
Protein nameMannose 6-phosphate/insulin-like growth factor-II receptor
Insulin like growth factor 2 receptor
Insulin-like growth factor type 2 receptor (Insulin-like growth factor type II receptor)
Cation-independent mannose-6-phosphate receptor (CI Man-6-P receptor) (CI-MPR) (M6PR) (300 kDa mannose 6-phosphate receptor) (MPR 300) (Insulin-like growth factor 2 receptor) (Insulin-like growth factor II receptor) (IGF-II receptor) (M6P/IGF2 receptor) (M6P/IGF2R) (CD antigen CD222)
Insulin-like growth factor type II receptor
Synonyms6-phosphate
mannose
MPRI
igf2R
DescriptionFUNCTION: Mediates the transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes . Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelysosomal compartment where the low pH mediates the dissociation of the complex . The receptor is then recycled back to the Golgi for another round of trafficking through its binding to the retromer . This receptor also binds IGF2 . Acts as a positive regulator of T-cell coactivation by binding DPP4 . .

AccessionsQ13661
A0A7I2V657
A0A7I2YQS7
ENST00000677704.1
A0A7I2V381
ENST00000678224.1
S4R328
A0N9R9
Q13660
A0N9R6
ENST00000475834.2
ENST00000356956.6
P11717
ENST00000676781.1
A0N9R7