I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| mesothelial cell | 4 studies | 43% ± 13% | |
| connective tissue cell | 4 studies | 25% ± 3% | |
| fibroblast | 3 studies | 21% ± 4% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| mesothelial cell | 4 studies | 43% ± 13% | |
| connective tissue cell | 4 studies | 25% ± 3% | |
| fibroblast | 3 studies | 21% ± 4% |
Insufficient scRNA-seq data for expression of NPW at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| ovary | 71% | 26.92 | 127 / 180 | 97% | 68.04 | 416 / 430 |
| liver | 100% | 384.23 | 226 / 226 | 60% | 35.15 | 244 / 406 |
| uterus | 89% | 61.29 | 151 / 170 | 51% | 22.84 | 234 / 459 |
| stomach | 79% | 48.70 | 284 / 359 | 55% | 17.67 | 158 / 286 |
| skin | 98% | 68.04 | 1764 / 1809 | 26% | 4.52 | 124 / 472 |
| esophagus | 37% | 9.47 | 536 / 1445 | 77% | 34.74 | 140 / 183 |
| thymus | 61% | 11.02 | 397 / 653 | 43% | 7.93 | 263 / 605 |
| spleen | 98% | 43.89 | 235 / 241 | 0% | 0 | 0 / 0 |
| prostate | 86% | 25.09 | 211 / 245 | 11% | 0.61 | 54 / 502 |
| pancreas | 80% | 16.80 | 261 / 328 | 16% | 6.91 | 29 / 178 |
| intestine | 47% | 9.95 | 455 / 966 | 46% | 12.66 | 245 / 527 |
| lung | 52% | 9.64 | 300 / 578 | 39% | 12.51 | 453 / 1155 |
| kidney | 85% | 23.07 | 76 / 89 | 1% | 0.20 | 12 / 901 |
| adrenal gland | 60% | 11.69 | 156 / 258 | 22% | 3.43 | 51 / 230 |
| brain | 56% | 11.59 | 1473 / 2642 | 17% | 1.42 | 119 / 705 |
| breast | 48% | 7.80 | 222 / 459 | 22% | 5.47 | 249 / 1118 |
| bladder | 43% | 7.90 | 9 / 21 | 22% | 3.99 | 112 / 504 |
| adipose | 56% | 15.13 | 677 / 1204 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 53% | 14.70 | 24 / 45 |
| peripheral blood | 37% | 6.43 | 344 / 929 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 36% | 2.89 | 29 / 80 |
| blood vessel | 22% | 3.15 | 296 / 1335 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 17% | 1.22 | 5 / 29 |
| heart | 17% | 2.62 | 144 / 861 | 0% | 0 | 0 / 0 |
| muscle | 7% | 0.89 | 56 / 803 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0007631 | Biological process | feeding behavior |
| GO_0007186 | Biological process | G protein-coupled receptor signaling pathway |
| GO_0007218 | Biological process | neuropeptide signaling pathway |
| GO_0005576 | Cellular component | extracellular region |
| GO_0005515 | Molecular function | protein binding |
| GO_0001664 | Molecular function | G protein-coupled receptor binding |
| Gene name | NPW |
| Protein name | Neuropeptide W (Preproprotein L8) (hPPL8) [Cleaved into: Neuropeptide W-23 (NPW23) (hL8); Neuropeptide W-30 (NPW30) (hL8C)] Neuropeptide W |
| Synonyms | PPL8 PPNPW |
| Description | FUNCTION: Plays a regulatory role in the organization of neuroendocrine signals accessing the anterior pituitary gland. Stimulates water drinking and food intake. May play a role in the hypothalamic response to stress (By similarity). NPW23 activates GPR7 and GPR8 more efficiently than NPW30. . |
| Accessions | Q8N729 ENST00000709296.1 ENST00000566435.4 ENST00000567649.1 H3BT42 H3BT17 ENST00000566435 |
