GPR88 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of GPR88 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of GPR88 at tissue level.

III. Associated gene sets

GO_0050885Biological processneuromuscular process controlling balance
GO_0007186Biological processG protein-coupled receptor signaling pathway
GO_0007188Biological processadenylate cyclase-modulating G protein-coupled receptor signaling pathway
GO_0007602Biological processphototransduction
GO_0009584Biological processdetection of visible light
GO_0071482Biological processcellular response to light stimulus
GO_0071875Biological processadrenergic receptor signaling pathway
GO_0019228Biological processneuronal action potential
GO_0061743Biological processmotor learning
GO_0007626Biological processlocomotory behavior
GO_0060170Cellular componentciliary membrane
GO_0005929Cellular componentcilium
GO_0005886Cellular componentplasma membrane
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0003774Molecular functioncytoskeletal motor activity
GO_0008020Molecular functionG protein-coupled photoreceptor activity
GO_0004941Molecular functionbeta2-adrenergic receptor activity

IV. Literature review

[source]
Gene nameGPR88
Protein nameG protein-coupled receptor 88 (Striatum-specific G-protein coupled receptor)
SynonymsSTRG
DescriptionFUNCTION: Orphan G protein-coupled receptor implicated in a large repertoire of behavioral responses that engage motor activities, spatial learning, and emotional processing (By similarity). May play a role in the regulation of cognitive and motor function (By similarity). Couples with the heterotrimeric G protein complex of the G(i) subfamily, consisting of GNAI1, GNB1 and GNG2, thereby acting through a G(i)-mediated pathway . Plays a role in the attenuation of D1 dopamine receptor (D1R)-mediated cAMP response in ciliated cells . In non-ciliated cells, involved in the inhibition of the beta-2 adrenergic receptor (B2AR) response . .

AccessionsQ9GZN0
ENST00000315033.5