C3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006957Biological processcomplement activation, alternative pathway
GO_0006954Biological processinflammatory response
GO_0010828Biological processpositive regulation of glucose transmembrane transport
GO_0016322Biological processneuron remodeling
GO_0150062Biological processcomplement-mediated synapse pruning
GO_0097278Biological processcomplement-dependent cytotoxicity
GO_0045766Biological processpositive regulation of angiogenesis
GO_0009617Biological processresponse to bacterium
GO_0007165Biological processsignal transduction
GO_0150064Biological processvertebrate eye-specific patterning
GO_0001934Biological processpositive regulation of protein phosphorylation
GO_0006956Biological processcomplement activation
GO_0006631Biological processfatty acid metabolic process
GO_0035846Biological processoviduct epithelium development
GO_0045745Biological processpositive regulation of G protein-coupled receptor signaling pathway
GO_0097242Biological processamyloid-beta clearance
GO_0048260Biological processpositive regulation of receptor-mediated endocytosis
GO_0006955Biological processimmune response
GO_0007186Biological processG protein-coupled receptor signaling pathway
GO_0001970Biological processpositive regulation of activation of membrane attack complex
GO_0006958Biological processcomplement activation, classical pathway
GO_2000427Biological processpositive regulation of apoptotic cell clearance
GO_0010575Biological processpositive regulation of vascular endothelial growth factor production
GO_0060100Biological processpositive regulation of phagocytosis, engulfment
GO_0010884Biological processpositive regulation of lipid storage
GO_0010866Biological processregulation of triglyceride biosynthetic process
GO_0001798Biological processpositive regulation of type IIa hypersensitivity
GO_0002430Biological processcomplement receptor mediated signaling pathway
GO_0035578Cellular componentazurophil granule lumen
GO_0005615Cellular componentextracellular space
GO_0005576Cellular componentextracellular region
GO_0005886Cellular componentplasma membrane
GO_0070062Cellular componentextracellular exosome
GO_0032991Cellular componentprotein-containing complex
GO_0034774Cellular componentsecretory granule lumen
GO_0072562Cellular componentblood microparticle
GO_0009986Cellular componentcell surface
GO_0005788Cellular componentendoplasmic reticulum lumen
GO_0004866Molecular functionendopeptidase inhibitor activity
GO_0005102Molecular functionsignaling receptor binding
GO_0031715Molecular functionC5L2 anaphylatoxin chemotactic receptor binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameC3
Protein nameComplement C3 (C3 and PZP-like alpha-2-macroglobulin domain-containing protein 1) [Cleaved into: Complement C3 beta chain; C3-beta-c (C3bc); Complement C3 alpha chain; C3a anaphylatoxin; Acylation stimulating protein (ASP) (C3adesArg); Complement C3b alpha' chain; Complement C3c alpha' chain fragment 1; Complement C3dg fragment; Complement C3g fragment; Complement C3d fragment; Complement C3f fragment; Complement C3c alpha' chain fragment 2]
Complement C3
SynonymsCPAMD1
DescriptionFUNCTION: C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates.; FUNCTION: Derived from proteolytic degradation of complement C3, C3a anaphylatoxin is a mediator of local inflammatory process. In chronic inflammation, acts as a chemoattractant for neutrophils (By similarity). It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes. .; FUNCTION: [C3-beta-c]: Acts as a chemoattractant for neutrophils in chronic inflammation. .; FUNCTION: [Acylation stimulating protein]: Adipogenic hormone that stimulates triglyceride (TG) synthesis and glucose transport in adipocytes, regulating fat storage and playing a role in postprandial TG clearance. Appears to stimulate TG synthesis via activation of the PLC, MAPK and AKT signaling pathways. Ligand for C5AR2. Promotes the phosphorylation, ARRB2-mediated internalization and recycling of C5AR2 . .

FUNCTION: Acts as a chemoattractant for neutrophils in chronic inflammation. .; FUNCTION: C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates. .

FUNCTION: Acts as a chemoattractant for neutrophils in chronic inflammation. .; FUNCTION: C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates. .

AccessionsENST00000695655.1
M0QXZ3
M0QYC8
ENST00000596548.1
A0A8Q3WM02
M0R1Q1
A0A8Q3SI34
P01024
A0A8Q3SI22
ENST00000602229.1
ENST00000245907.11
ENST00000695654.1
A0A8Q3SI05
ENST00000695653.1
A0A8Q3SI45
ENST00000695652.1
A0A8Q3WLS3
ENST00000594270.5
ENST00000600744.1
ENST00000695693.1
ENST00000601008.1
A0A8Q3WKN7
M0R0Q9
ENST00000695689.1