Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| B cell | 13 studies | 19% ± 5% | |
| glutamatergic neuron | 10 studies | 43% ± 25% | |
| naive B cell | 9 studies | 19% ± 3% | |
| retinal rod cell | 9 studies | 44% ± 16% | |
| retinal cone cell | 8 studies | 54% ± 16% | |
| amacrine cell | 7 studies | 37% ± 11% | |
| GABAergic neuron | 7 studies | 42% ± 22% | |
| platelet | 6 studies | 23% ± 10% | |
| neuron | 5 studies | 25% ± 5% | |
| retinal bipolar neuron | 5 studies | 52% ± 14% | |
| ON-bipolar cell | 5 studies | 49% ± 17% | |
| retinal ganglion cell | 5 studies | 64% ± 27% | |
| memory B cell | 5 studies | 18% ± 2% | |
| Mueller cell | 5 studies | 43% ± 9% | |
| endothelial cell | 4 studies | 27% ± 7% | |
| OFF-bipolar cell | 4 studies | 41% ± 19% | |
| astrocyte | 4 studies | 25% ± 5% | |
| retina horizontal cell | 4 studies | 28% ± 2% | |
| interneuron | 4 studies | 42% ± 13% | |
| epithelial cell | 3 studies | 39% ± 17% | |
| rod bipolar cell | 3 studies | 63% ± 4% | |
| oligodendrocyte precursor cell | 3 studies | 25% ± 7% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| kidney | 100% | 2096.15 | 89 / 89 | 99% | 6.90 | 889 / 901 |
| thymus | 100% | 1908.60 | 653 / 653 | 99% | 9.71 | 596 / 605 |
| brain | 99% | 4612.76 | 2610 / 2642 | 99% | 7.43 | 699 / 705 |
| uterus | 100% | 2967.42 | 170 / 170 | 97% | 6.46 | 444 / 459 |
| pancreas | 97% | 972.43 | 318 / 328 | 98% | 6.38 | 175 / 178 |
| prostate | 100% | 1771.68 | 245 / 245 | 95% | 4.39 | 475 / 502 |
| esophagus | 99% | 1416.69 | 1437 / 1445 | 95% | 4.92 | 174 / 183 |
| liver | 100% | 1225.80 | 225 / 226 | 94% | 7.06 | 382 / 406 |
| lung | 98% | 911.74 | 569 / 578 | 94% | 4.87 | 1086 / 1155 |
| adrenal gland | 99% | 1010.53 | 255 / 258 | 88% | 11.53 | 203 / 230 |
| breast | 99% | 1395.21 | 456 / 459 | 86% | 4.15 | 967 / 1118 |
| skin | 99% | 1194.74 | 1790 / 1809 | 86% | 4.55 | 406 / 472 |
| bladder | 100% | 2033.38 | 21 / 21 | 83% | 4.15 | 418 / 504 |
| ovary | 100% | 4429.47 | 180 / 180 | 74% | 2.86 | 317 / 430 |
| stomach | 98% | 948.34 | 351 / 359 | 67% | 2.44 | 191 / 286 |
| intestine | 97% | 1583.16 | 937 / 966 | 58% | 2.26 | 308 / 527 |
| lymph node | 0% | 0 | 0 / 0 | 100% | 5.71 | 29 / 29 |
| spleen | 100% | 1535.32 | 241 / 241 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 100% | 5.47 | 45 / 45 |
| ureter | 0% | 0 | 0 / 0 | 100% | 3.19 | 1 / 1 |
| blood vessel | 100% | 1844.26 | 1333 / 1335 | 0% | 0 | 0 / 0 |
| adipose | 99% | 1082.15 | 1188 / 1204 | 0% | 0 | 0 / 0 |
| heart | 75% | 934.36 | 648 / 861 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 66% | 3.11 | 53 / 80 |
| peripheral blood | 52% | 495.18 | 480 / 929 | 0% | 0 | 0 / 0 |
| muscle | 3% | 14.21 | 21 / 803 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_1990603 | Biological process | dark adaptation |
| GO_0043547 | Biological process | positive regulation of GTPase activity |
| GO_0007165 | Biological process | signal transduction |
| GO_1901386 | Biological process | negative regulation of voltage-gated calcium channel activity |
| GO_0007186 | Biological process | G protein-coupled receptor signaling pathway |
| GO_0036367 | Biological process | light adaption |
| GO_0007212 | Biological process | G protein-coupled dopamine receptor signaling pathway |
| GO_0098793 | Cellular component | presynapse |
| GO_1902773 | Cellular component | GTPase activator complex |
| GO_0005829 | Cellular component | cytosol |
| GO_0005737 | Cellular component | cytoplasm |
| GO_0005834 | Cellular component | heterotrimeric G-protein complex |
| GO_0005634 | Cellular component | nucleus |
| GO_0005096 | Molecular function | GTPase activator activity |
| GO_0051087 | Molecular function | protein-folding chaperone binding |
| GO_0030159 | Molecular function | signaling receptor complex adaptor activity |
| GO_0005515 | Molecular function | protein binding |
| GO_0031682 | Molecular function | G-protein gamma-subunit binding |
| GO_0003924 | Molecular function | GTPase activity |
| Gene name | GNB5 |
| Protein name | G protein subunit beta 5 Guanine nucleotide-binding protein subunit beta-5 (Gbeta5) (Transducin beta chain 5) |
| Synonyms | |
| Description | FUNCTION: Enhances GTPase-activating protein (GAP) activity of regulator of G protein signaling (RGS) proteins, such as RGS7 and RGS9, hence involved in the termination of the signaling initiated by the G protein coupled receptors (GPCRs) by accelerating the GTP hydrolysis on the G-alpha subunits, thereby promoting their inactivation . Increases RGS7 GTPase-activating protein (GAP) activity, thereby regulating mood and cognition (By similarity). Increases RGS9 GTPase-activating protein (GAP) activity, hence contributes to the deactivation of G protein signaling initiated by D(2) dopamine receptors . May play an important role in neuronal signaling, including in the parasympathetic, but not sympathetic, control of heart rate (By similarity). . |
| Accessions | H0YLU1 ENST00000396335.8 [O14775-3] ENST00000558519.5 ENST00000560116.1 ENST00000561313.5 Q96F32 O14775 ENST00000261837.12 [O14775-1] ENST00000358784.11 [O14775-2] H0YNW7 |