Name | Number of supported studies | Average coverage | |
---|---|---|---|
B cell | 13 studies | 19% ± 5% | |
glutamatergic neuron | 10 studies | 43% ± 25% | |
naive B cell | 9 studies | 19% ± 3% | |
retinal rod cell | 9 studies | 44% ± 16% | |
retinal cone cell | 8 studies | 54% ± 16% | |
amacrine cell | 7 studies | 37% ± 11% | |
GABAergic neuron | 7 studies | 42% ± 22% | |
platelet | 6 studies | 23% ± 10% | |
neuron | 5 studies | 25% ± 5% | |
retinal bipolar neuron | 5 studies | 52% ± 14% | |
ON-bipolar cell | 5 studies | 49% ± 17% | |
retinal ganglion cell | 5 studies | 64% ± 27% | |
memory B cell | 5 studies | 18% ± 2% | |
Mueller cell | 5 studies | 43% ± 9% | |
endothelial cell | 4 studies | 27% ± 7% | |
OFF-bipolar cell | 4 studies | 41% ± 19% | |
astrocyte | 4 studies | 25% ± 5% | |
retina horizontal cell | 4 studies | 28% ± 2% | |
interneuron | 4 studies | 42% ± 13% | |
epithelial cell | 3 studies | 39% ± 17% | |
rod bipolar cell | 3 studies | 63% ± 4% | |
oligodendrocyte precursor cell | 3 studies | 25% ± 7% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
kidney | 100% | 2096.15 | 89 / 89 | 99% | 6.90 | 889 / 901 |
thymus | 100% | 1908.60 | 653 / 653 | 99% | 9.71 | 596 / 605 |
brain | 99% | 4612.76 | 2610 / 2642 | 99% | 7.43 | 699 / 705 |
uterus | 100% | 2967.42 | 170 / 170 | 97% | 6.46 | 444 / 459 |
pancreas | 97% | 972.43 | 318 / 328 | 98% | 6.38 | 175 / 178 |
prostate | 100% | 1771.68 | 245 / 245 | 95% | 4.39 | 475 / 502 |
esophagus | 99% | 1416.69 | 1437 / 1445 | 95% | 4.92 | 174 / 183 |
liver | 100% | 1225.80 | 225 / 226 | 94% | 7.06 | 382 / 406 |
lung | 98% | 911.74 | 569 / 578 | 94% | 4.87 | 1086 / 1155 |
adrenal gland | 99% | 1010.53 | 255 / 258 | 88% | 11.53 | 203 / 230 |
breast | 99% | 1395.21 | 456 / 459 | 86% | 4.15 | 967 / 1118 |
skin | 99% | 1194.74 | 1790 / 1809 | 86% | 4.55 | 406 / 472 |
bladder | 100% | 2033.38 | 21 / 21 | 83% | 4.15 | 418 / 504 |
ovary | 100% | 4429.47 | 180 / 180 | 74% | 2.86 | 317 / 430 |
stomach | 98% | 948.34 | 351 / 359 | 67% | 2.44 | 191 / 286 |
intestine | 97% | 1583.16 | 937 / 966 | 58% | 2.26 | 308 / 527 |
lymph node | 0% | 0 | 0 / 0 | 100% | 5.71 | 29 / 29 |
spleen | 100% | 1535.32 | 241 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 100% | 5.47 | 45 / 45 |
ureter | 0% | 0 | 0 / 0 | 100% | 3.19 | 1 / 1 |
blood vessel | 100% | 1844.26 | 1333 / 1335 | 0% | 0 | 0 / 0 |
adipose | 99% | 1082.15 | 1188 / 1204 | 0% | 0 | 0 / 0 |
heart | 75% | 934.36 | 648 / 861 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 66% | 3.11 | 53 / 80 |
peripheral blood | 52% | 495.18 | 480 / 929 | 0% | 0 | 0 / 0 |
muscle | 3% | 14.21 | 21 / 803 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_1990603 | Biological process | dark adaptation |
GO_0043547 | Biological process | positive regulation of GTPase activity |
GO_0007165 | Biological process | signal transduction |
GO_1901386 | Biological process | negative regulation of voltage-gated calcium channel activity |
GO_0007186 | Biological process | G protein-coupled receptor signaling pathway |
GO_0036367 | Biological process | light adaption |
GO_0007212 | Biological process | G protein-coupled dopamine receptor signaling pathway |
GO_0098793 | Cellular component | presynapse |
GO_1902773 | Cellular component | GTPase activator complex |
GO_0005829 | Cellular component | cytosol |
GO_0005737 | Cellular component | cytoplasm |
GO_0005834 | Cellular component | heterotrimeric G-protein complex |
GO_0005634 | Cellular component | nucleus |
GO_0005096 | Molecular function | GTPase activator activity |
GO_0051087 | Molecular function | protein-folding chaperone binding |
GO_0030159 | Molecular function | signaling receptor complex adaptor activity |
GO_0005515 | Molecular function | protein binding |
GO_0031682 | Molecular function | G-protein gamma-subunit binding |
GO_0003924 | Molecular function | GTPase activity |
Gene name | GNB5 |
Protein name | G protein subunit beta 5 Guanine nucleotide-binding protein subunit beta-5 (Gbeta5) (Transducin beta chain 5) |
Synonyms | |
Description | FUNCTION: Enhances GTPase-activating protein (GAP) activity of regulator of G protein signaling (RGS) proteins, such as RGS7 and RGS9, hence involved in the termination of the signaling initiated by the G protein coupled receptors (GPCRs) by accelerating the GTP hydrolysis on the G-alpha subunits, thereby promoting their inactivation . Increases RGS7 GTPase-activating protein (GAP) activity, thereby regulating mood and cognition (By similarity). Increases RGS9 GTPase-activating protein (GAP) activity, hence contributes to the deactivation of G protein signaling initiated by D(2) dopamine receptors . May play an important role in neuronal signaling, including in the parasympathetic, but not sympathetic, control of heart rate (By similarity). . |
Accessions | H0YLU1 ENST00000396335.8 [O14775-3] ENST00000558519.5 ENST00000560116.1 ENST00000561313.5 Q96F32 O14775 ENST00000261837.12 [O14775-1] ENST00000358784.11 [O14775-2] H0YNW7 |