GNB5 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_1990603Biological processdark adaptation
GO_0043547Biological processpositive regulation of GTPase activity
GO_0007165Biological processsignal transduction
GO_1901386Biological processnegative regulation of voltage-gated calcium channel activity
GO_0007186Biological processG protein-coupled receptor signaling pathway
GO_0036367Biological processlight adaption
GO_0007212Biological processG protein-coupled dopamine receptor signaling pathway
GO_0098793Cellular componentpresynapse
GO_1902773Cellular componentGTPase activator complex
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0005834Cellular componentheterotrimeric G-protein complex
GO_0005634Cellular componentnucleus
GO_0005096Molecular functionGTPase activator activity
GO_0051087Molecular functionprotein-folding chaperone binding
GO_0030159Molecular functionsignaling receptor complex adaptor activity
GO_0005515Molecular functionprotein binding
GO_0031682Molecular functionG-protein gamma-subunit binding
GO_0003924Molecular functionGTPase activity

IV. Literature review

[source]
Gene nameGNB5
Protein nameG protein subunit beta 5
Guanine nucleotide-binding protein subunit beta-5 (Gbeta5) (Transducin beta chain 5)
Synonyms
DescriptionFUNCTION: Enhances GTPase-activating protein (GAP) activity of regulator of G protein signaling (RGS) proteins, such as RGS7 and RGS9, hence involved in the termination of the signaling initiated by the G protein coupled receptors (GPCRs) by accelerating the GTP hydrolysis on the G-alpha subunits, thereby promoting their inactivation . Increases RGS7 GTPase-activating protein (GAP) activity, thereby regulating mood and cognition (By similarity). Increases RGS9 GTPase-activating protein (GAP) activity, hence contributes to the deactivation of G protein signaling initiated by D(2) dopamine receptors . May play an important role in neuronal signaling, including in the parasympathetic, but not sympathetic, control of heart rate (By similarity). .

AccessionsH0YLU1
ENST00000396335.8 [O14775-3]
ENST00000558519.5
ENST00000560116.1
ENST00000561313.5
Q96F32
O14775
ENST00000261837.12 [O14775-1]
ENST00000358784.11 [O14775-2]
H0YNW7