PTPN6 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
B cell	34 studies	41% ± 16%	Explore
natural killer cell	26 studies	30% ± 11%	Explore
non-classical monocyte	25 studies	64% ± 20%	Explore
macrophage	24 studies	33% ± 13%	Explore
classical monocyte	24 studies	42% ± 16%	Explore
conventional dendritic cell	24 studies	41% ± 17%	Explore
CD8-positive, alpha-beta T cell	22 studies	28% ± 9%	Explore
monocyte	19 studies	38% ± 12%	Explore
memory B cell	19 studies	48% ± 13%	Explore
naive B cell	18 studies	39% ± 13%	Explore
CD4-positive, alpha-beta T cell	17 studies	22% ± 5%	Explore
regulatory T cell	15 studies	27% ± 6%	Explore
T cell	13 studies	24% ± 8%	Explore
mast cell	13 studies	26% ± 10%	Explore
mature NK T cell	13 studies	30% ± 10%	Explore
CD16-positive, CD56-dim natural killer cell, human	13 studies	35% ± 14%	Explore
plasmacytoid dendritic cell	13 studies	28% ± 9%	Explore
gamma-delta T cell	13 studies	31% ± 9%	Explore
dendritic cell	12 studies	45% ± 19%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	10 studies	27% ± 8%	Explore
myeloid cell	10 studies	36% ± 11%	Explore
CD16-negative, CD56-bright natural killer cell, human	9 studies	31% ± 11%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	9 studies	24% ± 6%	Explore
plasmablast	8 studies	34% ± 18%	Explore
CD8-positive, alpha-beta memory T cell	8 studies	28% ± 11%	Explore
plasma cell	7 studies	29% ± 9%	Explore
mucosal invariant T cell	7 studies	27% ± 6%	Explore
alveolar macrophage	6 studies	37% ± 12%	Explore
hematopoietic precursor cell	6 studies	34% ± 12%	Explore
CD4-positive, alpha-beta memory T cell	6 studies	22% ± 5%	Explore
neutrophil	6 studies	24% ± 4%	Explore
effector memory CD8-positive, alpha-beta T cell	6 studies	31% ± 10%	Explore
hematopoietic stem cell	6 studies	33% ± 13%	Explore
exhausted T cell	5 studies	37% ± 7%	Explore
immature B cell	5 studies	52% ± 24%	Explore
effector CD8-positive, alpha-beta T cell	5 studies	33% ± 13%	Explore
mononuclear phagocyte	4 studies	37% ± 20%	Explore
leukocyte	4 studies	28% ± 6%	Explore
precursor B cell	4 studies	46% ± 25%	Explore
T follicular helper cell	4 studies	24% ± 3%	Explore
intermediate monocyte	4 studies	51% ± 23%	Explore
effector memory CD4-positive, alpha-beta T cell	4 studies	24% ± 4%	Explore
brush cell	4 studies	37% ± 12%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	4 studies	25% ± 8%	Explore
common myeloid progenitor	3 studies	36% ± 22%	Explore
megakaryocyte	3 studies	33% ± 7%	Explore
epithelial cell	3 studies	22% ± 2%	Explore
intraepithelial lymphocyte	3 studies	44% ± 10%	Explore
germinal center B cell	3 studies	42% ± 8%	Explore
effector CD4-positive, alpha-beta T cell	3 studies	30% ± 12%	Explore
megakaryocyte-erythroid progenitor cell	3 studies	40% ± 25%	Explore
innate lymphoid cell	3 studies	26% ± 8%	Explore
group 3 innate lymphoid cell	3 studies	24% ± 7%	Explore
abnormal cell	3 studies	30% ± 14%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	16 studies	35% ± 9%	Explore
lung	4 studies	22% ± 6%	Explore
lymph node	4 studies	28% ± 1%	Explore
bone marrow	3 studies	25% ± 9%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
thymus	100%	2183.71	653 / 653	100%	46.09	605 / 605
lung	100%	5337.33	577 / 578	100%	45.76	1155 / 1155
liver	100%	1370.46	226 / 226	99%	21.82	403 / 406
kidney	100%	1893.42	89 / 89	99%	33.29	894 / 901
pancreas	98%	1173.59	321 / 328	100%	43.87	178 / 178
breast	97%	1412.06	444 / 459	100%	39.60	1114 / 1118
prostate	97%	2007.02	237 / 245	100%	27.08	500 / 502
adrenal gland	100%	2347.80	258 / 258	94%	18.85	216 / 230
stomach	94%	1418.06	338 / 359	99%	35.10	284 / 286
bladder	86%	1496.43	18 / 21	99%	46.38	500 / 504
intestine	82%	2774.19	794 / 966	100%	36.53	525 / 527
esophagus	79%	949.01	1142 / 1445	99%	27.07	181 / 183
skin	72%	1207.16	1301 / 1809	78%	26.89	369 / 472
uterus	52%	411.75	89 / 170	95%	39.01	434 / 459
ovary	27%	186.44	49 / 180	100%	33.09	430 / 430
brain	24%	209.69	637 / 2642	83%	16.16	587 / 705
lymph node	0%	0	0 / 0	100%	249.38	29 / 29
peripheral blood	100%	30488.95	929 / 929	0%	0	0 / 0
spleen	100%	21085.18	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	52.23	45 / 45
ureter	0%	0	0 / 0	100%	10.17	1 / 1
adipose	97%	1627.38	1167 / 1204	0%	0	0 / 0
blood vessel	54%	656.69	715 / 1335	0%	0	0 / 0
eye	0%	0	0 / 0	33%	5.51	26 / 80
heart	28%	200.72	239 / 861	0%	0	0 / 0
muscle	1%	7.97	12 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0045577	Biological process	regulation of B cell differentiation
GO_0019221	Biological process	cytokine-mediated signaling pathway
GO_0033630	Biological process	positive regulation of cell adhesion mediated by integrin
GO_0002244	Biological process	hematopoietic progenitor cell differentiation
GO_0008285	Biological process	negative regulation of cell population proliferation
GO_0006470	Biological process	protein dephosphorylation
GO_0000278	Biological process	mitotic cell cycle
GO_0060338	Biological process	regulation of type I interferon-mediated signaling pathway
GO_0070372	Biological process	regulation of ERK1 and ERK2 cascade
GO_0000165	Biological process	MAPK cascade
GO_0042098	Biological process	T cell proliferation
GO_0032715	Biological process	negative regulation of interleukin-6 production
GO_0050860	Biological process	negative regulation of T cell receptor signaling pathway
GO_0070527	Biological process	platelet aggregation
GO_0033007	Biological process	negative regulation of mast cell activation involved in immune response
GO_0031295	Biological process	T cell costimulation
GO_0050853	Biological process	B cell receptor signaling pathway
GO_2000045	Biological process	regulation of G1/S transition of mitotic cell cycle
GO_1905867	Biological process	epididymis development
GO_0035335	Biological process	peptidyl-tyrosine dephosphorylation
GO_0050852	Biological process	T cell receptor signaling pathway
GO_0035855	Biological process	megakaryocyte development
GO_0042267	Biological process	natural killer cell mediated cytotoxicity
GO_0016525	Biological process	negative regulation of angiogenesis
GO_0050732	Biological process	negative regulation of peptidyl-tyrosine phosphorylation
GO_0018108	Biological process	peptidyl-tyrosine phosphorylation
GO_0007186	Biological process	G protein-coupled receptor signaling pathway
GO_0035556	Biological process	intracellular signal transduction
GO_0042981	Biological process	regulation of apoptotic process
GO_0030154	Biological process	cell differentiation
GO_0002924	Biological process	negative regulation of humoral immune response mediated by circulating immunoglobulin
GO_0042130	Biological process	negative regulation of T cell proliferation
GO_0043409	Biological process	negative regulation of MAPK cascade
GO_0051897	Biological process	positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
GO_0008284	Biological process	positive regulation of cell population proliferation
GO_0051279	Biological process	regulation of release of sequestered calcium ion into cytosol
GO_0106015	Biological process	negative regulation of inflammatory response to wounding
GO_0032720	Biological process	negative regulation of tumor necrosis factor production
GO_0030220	Biological process	platelet formation
GO_0005730	Cellular component	nucleolus
GO_0005576	Cellular component	extracellular region
GO_0005886	Cellular component	plasma membrane
GO_0035580	Cellular component	specific granule lumen
GO_0016020	Cellular component	membrane
GO_0070062	Cellular component	extracellular exosome
GO_0032991	Cellular component	protein-containing complex
GO_0005654	Cellular component	nucleoplasm
GO_0005911	Cellular component	cell-cell junction
GO_0042105	Cellular component	alpha-beta T cell receptor complex
GO_1904724	Cellular component	tertiary granule lumen
GO_0005829	Cellular component	cytosol
GO_0005737	Cellular component	cytoplasm
GO_0005634	Cellular component	nucleus
GO_0004726	Molecular function	non-membrane spanning protein tyrosine phosphatase activity
GO_0005001	Molecular function	transmembrane receptor protein tyrosine phosphatase activity
GO_0019901	Molecular function	protein kinase binding
GO_0042169	Molecular function	SH2 domain binding
GO_0004725	Molecular function	protein tyrosine phosphatase activity
GO_0050839	Molecular function	cell adhesion molecule binding
GO_0140031	Molecular function	phosphorylation-dependent protein binding
GO_0005515	Molecular function	protein binding
GO_0001784	Molecular function	phosphotyrosine residue binding
GO_0017124	Molecular function	SH3 domain binding

IV. Literature review

[source]

Gene name	PTPN6
Protein name	protein-tyrosine-phosphatase (EC 3.1.3.48) Tyrosine-protein phosphatase non-receptor type 6 (EC 3.1.3.48) (Hematopoietic cell protein-tyrosine phosphatase) (Protein-tyrosine phosphatase 1C) (PTP-1C) (Protein-tyrosine phosphatase SHP-1) (SH-PTP1) Tyrosine-protein phosphatase non-receptor type (EC 3.1.3.48)
Synonyms	hCG_25941 PTP1C HCP
Description	FUNCTION: Modulates signaling by tyrosine phosphorylated cell surface receptors such as KIT and the EGF receptor/EGFR. The SH2 regions may interact with other cellular components to modulate its own phosphatase activity against interacting substrates. Together with MTUS1, induces UBE2V2 expression upon angiotensin II stimulation. Plays a key role in hematopoiesis. .
Accessions	F5H0N8 ENST00000456013.5 [P29350-4] ENST00000545153.5 F5GY79 P29350 ENST00000399448.5 [P29350-3] ENST00000536013.5 ENST00000542848.5 U3KQS1 F5H1Z8 ENST00000535462.5 F5GXD4 ENST00000543115.5 F5H1V7 ENST00000541698.5 ENST00000542462.1 F5H4Z1 ENST00000318974.14 [P29350-1] Q53XS4 F5H5H9 ENST00000538715.5

PTPN6 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review