CALM1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0060315Biological processnegative regulation of ryanodine-sensitive calcium-release channel activity
GO_0140056Biological processorganelle localization by membrane tethering
GO_0051343Biological processpositive regulation of cyclic-nucleotide phosphodiesterase activity
GO_0002027Biological processregulation of heart rate
GO_0032465Biological processregulation of cytokinesis
GO_0060316Biological processpositive regulation of ryanodine-sensitive calcium-release channel activity
GO_0035458Biological processcellular response to interferon-beta
GO_0016240Biological processautophagosome membrane docking
GO_0010881Biological processregulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
GO_0010801Biological processnegative regulation of peptidyl-threonine phosphorylation
GO_0007186Biological processG protein-coupled receptor signaling pathway
GO_0098901Biological processregulation of cardiac muscle cell action potential
GO_0050848Biological processregulation of calcium-mediated signaling
GO_0021762Biological processsubstantia nigra development
GO_0031954Biological processpositive regulation of protein autophosphorylation
GO_1990456Biological processmitochondrion-endoplasmic reticulum membrane tethering
GO_0000086Biological processG2/M transition of mitotic cell cycle
GO_1901842Biological processnegative regulation of high voltage-gated calcium channel activity
GO_0010880Biological processregulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
GO_0032516Biological processpositive regulation of phosphoprotein phosphatase activity
GO_0010800Biological processpositive regulation of peptidyl-threonine phosphorylation
GO_1905913Biological processnegative regulation of calcium ion export across plasma membrane
GO_1901844Biological processregulation of cell communication by electrical coupling involved in cardiac conduction
GO_0055117Biological processregulation of cardiac muscle contraction
GO_0071902Biological processpositive regulation of protein serine/threonine kinase activity
GO_0060314Biological processregulation of ryanodine-sensitive calcium-release channel activity
GO_0046427Biological processpositive regulation of receptor signaling pathway via JAK-STAT
GO_0051592Biological processresponse to calcium ion
GO_0035307Biological processpositive regulation of protein dephosphorylation
GO_0005513Biological processdetection of calcium ion
GO_0071346Biological processcellular response to type II interferon
GO_0005876Cellular componentspindle microtubule
GO_1902494Cellular componentcatalytic complex
GO_0005576Cellular componentextracellular region
GO_0031982Cellular componentvesicle
GO_0043209Cellular componentmyelin sheath
GO_0005886Cellular componentplasma membrane
GO_0000922Cellular componentspindle pole
GO_0005813Cellular componentcentrosome
GO_0032991Cellular componentprotein-containing complex
GO_0005654Cellular componentnucleoplasm
GO_0030017Cellular componentsarcomere
GO_0005829Cellular componentcytosol
GO_0034704Cellular componentcalcium channel complex
GO_0005737Cellular componentcytoplasm
GO_0097225Cellular componentsperm midpiece
GO_0008076Cellular componentvoltage-gated potassium channel complex
GO_0005634Cellular componentnucleus
GO_0031432Molecular functiontitin binding
GO_0019901Molecular functionprotein kinase binding
GO_0043539Molecular functionprotein serine/threonine kinase activator activity
GO_0048306Molecular functioncalcium-dependent protein binding
GO_0044325Molecular functiontransmembrane transporter binding
GO_0019855Molecular functioncalcium channel inhibitor activity
GO_0072542Molecular functionprotein phosphatase activator activity
GO_0005509Molecular functioncalcium ion binding
GO_0005515Molecular functionprotein binding
GO_0010856Molecular functionadenylate cyclase activator activity

IV. Literature review

[source]
Gene nameCALM1
Protein nameCalmodulin-1
Calmodulin 1
CALM1 protein (Calmodulin 1) (Calmodulin 2) (Calmodulin 3) (LP7057 protein)
Calmodulin 1 (Phosphorylase kinase, delta), isoform CRA_a (Calmodulin 3 (Phosphorylase kinase, delta), isoform CRA_b) (Epididymis secretory protein Li 72) (cDNA FLJ61744, highly similar to Calmodulin)
SynonymsCALM2
hCG_17033
CAM
hCG_20313
HEL-S-72
CAM1
CALM
hCG_21749
CALM3
DescriptionFUNCTION: Calmodulin acts as part of a calcium signal transduction pathway by mediating the control of a large number of enzymes, ion channels, aquaporins and other proteins through calcium-binding . Calcium-binding is required for the activation of calmodulin . Among the enzymes to be stimulated by the calmodulin-calcium complex are a number of protein kinases, such as myosin light-chain kinases and calmodulin-dependent protein kinase type II (CaMK2), and phosphatases . Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis . Is a regulator of voltage-dependent L-type calcium channels . Mediates calcium-dependent inactivation of CACNA1C . Positively regulates calcium-activated potassium channel activity of KCNN2 . Forms a potassium channel complex with KCNQ1 and regulates electrophysiological activity of the channel via calcium-binding . Acts as a sensor to modulate the endoplasmic reticulum contacts with other organelles mediated by VMP1:ATP2A2 . .; FUNCTION: (Microbial infection) Required for Legionella pneumophila SidJ glutamylase activity. .; FUNCTION: (Microbial infection) Required for C.violaceum CopC and S.flexneri OspC3 arginine ADP-riboxanase activity. .

AccessionsENST00000456319.6
ENST00000447653.8
B4DJ51
ENST00000663135.1
ENST00000356978.9
ENST00000557020.5
ENST00000391918.6
ENST00000656538.1
ENST00000655728.1
ENST00000668667.1
ENST00000599839.5
ENST00000553422.1
ENST00000655450.1
ENST00000553630.1
G3V361
P0DP23
ENST00000659177.1
G3V479
Q96HY3
ENST00000598871.5
G3V226
ENST00000544280.6
ENST00000594523.5
ENST00000553542.5